PMID- 35284219
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220315
IS  - 2211-4122 (Print)
IS  - 2347-193X (Electronic)
IS  - 2211-4122 (Linking)
VI  - 31
IP  - 4
DP  - 2021 Oct-Dec
TI  - A Subtle Decline in Cardiac Mechanics is correlated with Albuminuria in 
      Asymptomatic Normotensive Patients with Type 2 Diabetes Mellitus: A Two 
      Dimensional Strain Echocardiography Study.
PG  - 220-226
LID - 10.4103/jcecho.jcecho_36_21 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) insidiously affects the myocardium 
      with subsequent cardiomyopathy and induces microvascular damage in the kidneys 
      reflected by albuminuria. We aimed to investigate the relationship between 
      albuminuria and subclinical left ventricular (LV) systolic dysfunction in 
      asymptomatic normotensive patients with T2DM assessed by two-dimensional 
      speckle-tracking echocardiography. MATERIALS AND METHODS AND RESULTS: Sixty 
      normotensive patients with T2DM were included and subdivided into two subgroups, 
      each including thirty patients according to the presence of albuminuria, together 
      with thirty control subjects. All underwent echocardiographic examination, 
      including LV regional and global longitudinal strain (GLS) measurements. 
      Laboratory tests were withdrawn, including serum glycated hemoglobin (HbA1C) and 
      albumin-creatinine ratio (ACR). When compared to the control group, patients with 
      T2DM had a significantly lower average peak systolic LV GLS (-16.18% +/- 2.78% vs. 
      -18.13% +/- 2.86%, P < 0.001), however, there was no significant difference in 
      average peak systolic LV GLS between both diabetic subgroups (-15.57% +/- 2.77% in 
      the albuminuric subgroup vs. -16.79% +/- 2.70% in the nonalbuminuric subgroup, P = 
      0.077). Moreover, there was a significant correlation between ACR and reduction 
      of GLS in patients with T2DM and albuminuria (r = 0.55, P = 0.002). However, this 
      correlation was absent in patients with T2DM without albuminuria (r = 0.107, P = 
      0.573). CONCLUSIONS: Patients with T2DM have subclinical LV systolic dysfunction 
      with a reduction of average LV GLS that correlates with ACR in patients with T2DM 
      and albuminuria.
CI  - Copyright: (c) 2022 Journal of Cardiovascular Echography.
FAU - Abdellatif, Yasser A
AU  - Abdellatif YA
AD  - Department of Cardiology, Ain Shams University Hospital Abbassiya, Cairo, Egypt.
FAU - Nazmy, Nour Eldin M
AU  - Nazmy NEM
AD  - Department of Cardiology, Ain Shams University Hospital Abbassiya, Cairo, Egypt.
FAU - Bastawy, Islam M
AU  - Bastawy IM
AD  - Department of Cardiology, Ain Shams University Hospital Abbassiya, Cairo, Egypt.
FAU - Raafat, Sameh S
AU  - Raafat SS
AD  - Department of Cardiology, Ain Shams University Hospital Abbassiya, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20220124
PL  - India
TA  - J Cardiovasc Echogr
JT  - Journal of cardiovascular echography
JID - 101562228
PMC - PMC8893108
OTO - NOTNLM
OT  - Albuminuria
OT  - diabetes mellitus
OT  - diabetic cardiomyopathy
OT  - left ventricular function
OT  - two-dimensional strain
COIS- There are no conflicts of interest.
EDAT- 2022/03/15 06:00
MHDA- 2022/03/15 06:01
PMCR- 2021/10/01
CRDT- 2022/03/14 05:59
PHST- 2021/05/04 00:00 [received]
PHST- 2021/09/24 00:00 [revised]
PHST- 2021/10/20 00:00 [accepted]
PHST- 2022/03/14 05:59 [entrez]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/03/15 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - JCE-31-220 [pii]
AID - 10.4103/jcecho.jcecho_36_21 [doi]
PST - ppublish
SO  - J Cardiovasc Echogr. 2021 Oct-Dec;31(4):220-226. doi: 
      10.4103/jcecho.jcecho_36_21. Epub 2022 Jan 24.