PMID- 35285199
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20220315
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 47
IP  - 4
DP  - 2022 Feb
TI  - [Shenling Baizhu Powder alleviates chronic inflammation to prevent type 2 
      diabetes of ZDF rats via intestinal flora].
PG  - 988-1000
LID - 10.19540/j.cnki.cjcmm.20210907.401 [doi]
AB  - This study explored the mechanism of Shenling Baizhu Powder(SLBZP) in the 
      prevention and treatment of type 2 diabetes from the perspective of flora 
      disorder and chronic inflammation. Fifty rats were randomly divided into normal 
      control group, model control group, low-dose SLBZP group, medium-dose SLBZP 
      group, and high-dose SLBZP group, with 10 rats in each group. The rats of 5 weeks 
      old were administrated by gavage with ultrapure water and different doses of 
      SLBZP decoction. The basic indicators such as body weight and blood glucose were 
      monitored every week, and stool and intestinal contents were collected from the 
      rats of 9 weeks old for 16 S rRNA sequencing and metabolomic analysis. An 
      automatic biochemical analyzer was used to measure the serum biochemical 
      indicators, ELISA to measure serum insulin, and chipsets to measure leptin and 
      inflammatory cytokines. The results showed that SLBZP reduced the body weight as 
      well as blood glucose, glycosylated hemoglobin, and lipid levels. In the rats of 
      9 weeks, the relative abundance of Anaerostipes, Turicibacter, Bilophila, 
      Ochrobactrum, Acinetobacter, and Prevotella decreased significantly in the model 
      control group, which can be increased in the high-dose SLBZP group; the relative 
      abundance of Psychrobacter, Lactobacillus, Roseburia and Staphylococcus 
      significantly increased in the model control group, which can be down-regulated 
      in the high-dose SLBZP group. The differential metabolites of intestinal flora 
      included 4-hydroxyphenylpyruvic acid, phenylpyruvic acid, octanoic acid, 
      3-indolepropionic acid, oxoglutaric acid, malonic acid, 3-methyl-2-oxovaleric 
      acid, and methylmalonic acid. Moreover, SLBZP significantly lowered the levels of 
      free insulin, insulin resistance and leptin resistance in rats. The variations in 
      the serum levels of interleukin 1beta(IL-1beta) and monocyte chemoattractant 
      protein-1(MCP-1) showed that SLBZP could alleviate chronic inflammation in rats. 
      In conclusion, SLBZP can regulate intestinal flora and metabolites and relieve 
      chronic inflammation to control obesity and prevent type 2 diabetes.
FAU - Zhang, Li-Jing
AU  - Zhang LJ
AD  - Modern Research Laboratory of Spleen Visceral Manifestations Theory, School of 
      Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing 
      University of Chinese Medicine Nanjing 210023, China.
FAU - Zhan, Li-Bin
AU  - Zhan LB
AD  - Center for Innovative Engineering Technology in Traditional Chinese Medicine, 
      Liaoning University of Traditional Chinese Medicine Shenyang 110847, China.
FAU - Hang, Tian-Yi
AU  - Hang TY
AD  - Modern Research Laboratory of Spleen Visceral Manifestations Theory, School of 
      Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing 
      University of Chinese Medicine Nanjing 210023, China.
FAU - Luo, Jin-Tong
AU  - Luo JT
AD  - Modern Research Laboratory of Spleen Visceral Manifestations Theory, School of 
      Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing 
      University of Chinese Medicine Nanjing 210023, China.
FAU - Zhao, Chun-Yan
AU  - Zhao CY
AD  - Modern Research Laboratory of Spleen Visceral Manifestations Theory, School of 
      Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing 
      University of Chinese Medicine Nanjing 210023, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Insulin)
RN  - 0 (Powders)
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - *Gastrointestinal Microbiome
MH  - Inflammation/drug therapy
MH  - Insulin
MH  - Powders
MH  - Rats
OTO - NOTNLM
OT  - Shenling Baizhu Powder
OT  - chronic inflammation
OT  - intestinal flora
OT  - metabolites
EDAT- 2022/03/15 06:00
MHDA- 2022/03/16 06:00
CRDT- 2022/03/14 06:04
PHST- 2022/03/14 06:04 [entrez]
PHST- 2022/03/15 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
AID - 10.19540/j.cnki.cjcmm.20210907.401 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2022 Feb;47(4):988-1000. doi: 
      10.19540/j.cnki.cjcmm.20210907.401.