PMID- 35289012
OWN - NLM
STAT- MEDLINE
DCOM- 20221101
LR  - 20221103
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Print)
IS  - 1015-6305 (Linking)
VI  - 32
IP  - 6
DP  - 2022 Nov
TI  - Pathological changes within the cerebral vasculature in Alzheimer's disease: New 
      perspectives.
PG  - e13061
LID - 10.1111/bpa.13061 [doi]
LID - e13061
AB  - Cerebrovascular disease underpins vascular dementia (VaD), but structural and 
      functional changes to the cerebral vasculature contribute to disease pathology 
      and cognitive decline in Alzheimer's disease (AD). In this review, we discuss the 
      contribution of cerebral amyloid angiopathy and non-amyloid small vessel disease 
      in AD, and the accompanying changes to the density, maintenance and remodelling 
      of vessels (including alterations to the composition and function of the 
      cerebrovascular basement membrane). We consider how abnormalities of the 
      constituent cells of the neurovascular unit - particularly of endothelial cells 
      and pericytes - and impairment of the blood-brain barrier (BBB) impact on the 
      pathogenesis of AD. We also discuss how changes to the cerebral vasculature are 
      likely to impair Abeta clearance - both intra-periarteriolar drainage (IPAD) and 
      transport of Abeta peptides across the BBB, and how impaired neurovascular coupling 
      and reduced blood flow in relation to metabolic demand increase amyloidogenic 
      processing of APP and the production of Abeta. We review the vasoactive properties 
      of Abeta peptides themselves, and the probable bi-directional relationship between 
      vascular dysfunction and Abeta accumulation in AD. Lastly, we discuss recent 
      methodological advances in transcriptomics and imaging that have provided novel 
      insights into vascular changes in AD, and recent advances in assessment of the 
      retina that allow in vivo detection of vascular changes in the early stages of 
      AD.
CI  - (c) 2022 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf 
      of International Society of Neuropathology.
FAU - Fisher, Robert A
AU  - Fisher RA
AUID- ORCID: 0000-0002-0387-290X
AD  - Dementia Research Group, University of Bristol Medical School, Bristol, UK.
FAU - Miners, J Scott
AU  - Miners JS
AUID- ORCID: 0000-0001-8594-1640
AD  - Dementia Research Group, University of Bristol Medical School, Bristol, UK.
FAU - Love, Seth
AU  - Love S
AUID- ORCID: 0000-0001-8683-3625
AD  - Dementia Research Group, University of Bristol Medical School, Bristol, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220314
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Humans
MH  - *Alzheimer Disease/pathology
MH  - Amyloid beta-Peptides/metabolism
MH  - Endothelial Cells/pathology
MH  - *Cerebral Amyloid Angiopathy/pathology
MH  - Blood-Brain Barrier/pathology
MH  - Brain/pathology
PMC - PMC9616094
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - blood-brain barrier
OT  - cerebral blood flow
OT  - neurovascular coupling
OT  - pericyte
OT  - vasculature
COIS- We have no conflicts of interest to declare.
EDAT- 2022/03/16 06:00
MHDA- 2022/11/02 06:00
PMCR- 2022/03/14
CRDT- 2022/03/15 05:47
PHST- 2022/02/11 00:00 [revised]
PHST- 2021/12/10 00:00 [received]
PHST- 2022/02/21 00:00 [accepted]
PHST- 2022/03/16 06:00 [pubmed]
PHST- 2022/11/02 06:00 [medline]
PHST- 2022/03/15 05:47 [entrez]
PHST- 2022/03/14 00:00 [pmc-release]
AID - BPA13061 [pii]
AID - 10.1111/bpa.13061 [doi]
PST - ppublish
SO  - Brain Pathol. 2022 Nov;32(6):e13061. doi: 10.1111/bpa.13061. Epub 2022 Mar 14.