PMID- 35289372
OWN - NLM
STAT- MEDLINE
DCOM- 20230306
LR  - 20230306
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 33
IP  - 2
DP  - 2023 Mar 2
TI  - Effectiveness of tacrolimus concomitant with biological disease-modifying 
      antirheumatic drugs in patients with rheumatoid arthritis.
PG  - 292-301
LID - 10.1093/mr/roac025 [doi]
AB  - OBJECTIVES: The study aimed to investigate the effectiveness and tolerance of 
      biological disease-modifying antirheumatic drugs (bDMARDs) therapy administered 
      concomitantly with tacrolimus (TAC) treatment in patients with rheumatoid 
      arthritis. METHODS: 2792 patients who underwent therapy with five bDMARDs 
      (etanercept: ETN, adalimumab, golimumab, tocilizumab, and abatacept: ABT) were 
      enrolled. Among the study subjects, 1582 were concomitant methotrexate (MTX 
      group), 147 were concomitant TAC (TAC group), and 1063 were non-concomitant MTX 
      and TAC (non-MTX/TAC group). The primary outcome was the incident rate of 
      discontinuation of bDMARDs by adverse events (AEs) or loss of efficacy. RESULTS: 
      Concerning the analysis for each reasons of discontinuation, including AEs and 
      loss of efficacy, the hazards ratio (HR) was significantly lower in the TAC group 
      than in non-MTX/TAC groups (AEs: HR = 0.39, 95% confidence interval, 0.23-0.68, 
      loss of efficacy: HR = 0.49, 95% confidence interval, 0.30-0.78). The loss of 
      efficacy with the use of ETN and ABT was lower in the TAC group than in 
      non-MTX/TAC groups. Concomitant TAC did not induce elevated risk for 
      discontinuation of AEs in all bDMARD analyses. CONCLUSIONS: Concomitant TAC with 
      ABT or ETN showed higher retention rates than bDMARDs therapy without TAC or MTX. 
      AEs did not increase over long-term observation.
CI  - (c) Japan College of Rheumatology 2022. Published by Oxford University Press. All 
      rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
FAU - Terabe, Kenya
AU  - Terabe K
AUID- ORCID: 0000-0001-6469-1312
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Takahashi, Nobunori
AU  - Takahashi N
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Asai, Shuji
AU  - Asai S
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Hirano, Yuji
AU  - Hirano Y
AD  - Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan.
FAU - Kanayama, Yasuhide
AU  - Kanayama Y
AD  - Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.
FAU - Yabe, Yuichiro
AU  - Yabe Y
AD  - Department of Rheumatology, Tokyo Shinjuku Medical Center, Tokyo, Japan.
FAU - Oguchi, Takeshi
AU  - Oguchi T
AD  - Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.
FAU - Fujibayashi, Takayoshi
AU  - Fujibayashi T
AD  - Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.
FAU - Ishikawa, Hisato
AU  - Ishikawa H
AD  - Department of Orthopedic Surgery, Japanese Red Cross Aichi Medical Center Nagoya 
      Daiichi Hospital, Nagoya, Japan.
FAU - Hanabayashi, Masahiro
AU  - Hanabayashi M
AD  - Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya, 
      Japan.
FAU - Hattori, Yosuke
AU  - Hattori Y
AD  - Department of Orthopedic Surgery, National Hospital Organization Nagoya Medical 
      Center, Nagoya, Japan.
FAU - Suzuki, Mochihito
AU  - Suzuki M
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Kishimoto, Kenji
AU  - Kishimoto K
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Ohashi, Yoshifumi
AU  - Ohashi Y
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Imaizumi, Takahiro
AU  - Imaizumi T
AD  - Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.
FAU - Imagama, Shiro
AU  - Imagama S
AUID- ORCID: 0000-0002-6951-8575
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Kojima, Toshihisa
AU  - Kojima T
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Antirheumatic Agents)
RN  - WM0HAQ4WNM (Tacrolimus)
RN  - YL5FZ2Y5U1 (Methotrexate)
RN  - OP401G7OJC (Etanercept)
SB  - IM
MH  - Humans
MH  - *Antirheumatic Agents/adverse effects
MH  - Tacrolimus/adverse effects
MH  - Treatment Outcome
MH  - *Arthritis, Rheumatoid/drug therapy
MH  - Methotrexate/adverse effects
MH  - Etanercept/therapeutic use
MH  - Drug Therapy, Combination
OTO - NOTNLM
OT  - abatacept
OT  - biological disease-modifying antirheumatic drugs; 
OT  - etanercept; 
OT  - rheumatoid arthritis; 
OT  - tacrolimus; 
EDAT- 2022/03/16 06:00
MHDA- 2023/03/07 06:00
CRDT- 2022/03/15 08:43
PHST- 2021/11/09 00:00 [received]
PHST- 2022/01/22 00:00 [revised]
PHST- 2022/02/09 00:00 [accepted]
PHST- 2022/03/16 06:00 [pubmed]
PHST- 2023/03/07 06:00 [medline]
PHST- 2022/03/15 08:43 [entrez]
AID - 6548676 [pii]
AID - 10.1093/mr/roac025 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2023 Mar 2;33(2):292-301. doi: 10.1093/mr/roac025.