PMID- 35292339
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220728
IS  - 1532-8406 (Electronic)
IS  - 0883-5403 (Linking)
VI  - 37
IP  - 7S
DP  - 2022 Jul
TI  - Do Patient Outcomes Vary by Patient Age Following Primary Total Hip Arthroplasty?
PG  - S510-S516
LID - S0883-5403(22)00303-5 [pii]
LID - 10.1016/j.arth.2022.03.032 [doi]
AB  - BACKGROUND: Multiple authors have sought to determine what patient 
      characteristics influence outcome after total hip arthroplasty (THA). Age has 
      shown no effect on outcome in some evaluations, while others have reported higher 
      functional improvement in younger patients. The aim of this study was to 
      determine if outcome after THA varies based on patient age. METHODS: A 
      prospective, multicenter cohort of 7,934 unilateral primary THA patients from the 
      FORCE-TJR comparative effectiveness consortium was evaluated. Demographic data, 
      comorbid conditions, and Patient-Reported Outcome Measures, including (HOOS), 
      HOOS-12, HOOS JR, and SF-36 (PCS) and (MCS), were collected preop and at 1-year 
      postop. Descriptive statistics were generated, stratified by age (<55 years 
      [younger adult], 55-64 years [older adult], 65-74 years [early elder], and >/=75 
      years [late elder]), and differences in pain, function, and quality of life among 
      the 4 age groups were evaluated. A multivariate regression model with 95% 
      confidence interval (CI) was used to assess the role of patient age as a 
      predictive factor for HOOS pain and function scores reported 1 year after primary 
      THA. RESULTS: Prior to surgery, younger patients (<55 years) reported worse pain, 
      function, and quality of life than the other 3 patient groups. At 1 year after 
      THA, younger patients (<55 years) reported slightly worse pain and quality of 
      life but better function scores than the 3 older patients' groups. Younger 
      patients (<55 years) achieved higher baseline to 1-year pain, and function score 
      changes when compared to the older patients' groups. The quality of life score 
      changes was not different among the 4 age groups. The differences in 1-year 
      postop scores (ranging from 2.74 to 8.46) and the magnitude of score changes from 
      baseline to 1 year (ranging from 1.9 to 5.85), although statistically significant 
      (P < .001), did not reach the minimal clinically important difference (MCID). The 
      multivariate regression analysis shows that age is a significant predictor for 
      pain at 1 year but not for function. Although HOOS pain score is predicted to be 
      higher by 4.38 points (less pain) 1 year after THA in older patients (>/=75), when 
      compared to younger patients (<55 years), again the difference is well below the 
      MCID and is clinically insignificant. CONCLUSION: Although there are 
      statistically significant differences in pain relief, functional improvement, and 
      quality of life between younger and older patients among different patients' age 
      groups, there is no clinically significant difference. THA provides an 
      improvement in quality of life by decreasing pain and increasing function in all 
      4 age groups, with large improvements in Patient-Reported Outcome Measures scores 
      (>2 standard deviations) without clinically significant age-related differences 
      in THA outcome at 1 year.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Ayers, David C
AU  - Ayers DC
AD  - Department of Orthopedics and Physical Rehabilitation, University of 
      Massachusetts Chan Medical School, Worcester, Massachusetts.
FAU - Yousef, Mohamed
AU  - Yousef M
AD  - Department of Orthopedics and Physical Rehabilitation, University of 
      Massachusetts Chan Medical School, Worcester, Massachusetts; Department of 
      Orthopaedic Surgery, Sohag University, Sohag, Egypt.
FAU - Zheng, Hua
AU  - Zheng H
AD  - Department of Orthopedics and Physical Rehabilitation, University of 
      Massachusetts Chan Medical School, Worcester, Massachusetts.
FAU - Yang, Wenyun
AU  - Yang W
AD  - Department of Commonwealth Medicine, Public and Private Health Solutions, 
      University of Massachusetts Chan Medical School, Worcester, Massachusetts.
FAU - Franklin, Patricia D
AU  - Franklin PD
AD  - Department of Medical Social Sciences, Northwestern Feinberg School of Medicine, 
      Chicago, Illinois.
LA  - eng
GR  - P50 HS018910/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20220312
PL  - United States
TA  - J Arthroplasty
JT  - The Journal of arthroplasty
JID - 8703515
SB  - IM
MH  - Aged
MH  - *Arthroplasty, Replacement, Hip
MH  - Humans
MH  - Middle Aged
MH  - *Osteoarthritis, Hip/surgery
MH  - Pain/surgery
MH  - Patient Reported Outcome Measures
MH  - Prospective Studies
MH  - Quality of Life
MH  - Treatment Outcome
OTO - NOTNLM
OT  - function
OT  - old age
OT  - patient-reported outcome
OT  - quality of life
OT  - total joint replacement
OT  - young age
EDAT- 2022/03/17 06:00
MHDA- 2022/06/09 06:00
CRDT- 2022/03/16 05:43
PHST- 2021/12/01 00:00 [received]
PHST- 2022/03/06 00:00 [revised]
PHST- 2022/03/08 00:00 [accepted]
PHST- 2022/03/17 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2022/03/16 05:43 [entrez]
AID - S0883-5403(22)00303-5 [pii]
AID - 10.1016/j.arth.2022.03.032 [doi]
PST - ppublish
SO  - J Arthroplasty. 2022 Jul;37(7S):S510-S516. doi: 10.1016/j.arth.2022.03.032. Epub 
      2022 Mar 12.