PMID- 35293029
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220414
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 36
IP  - 4
DP  - 2022 Apr
TI  - Serum lutein is a promising biomarker for type 2 diabetes mellitus and diabetic 
      kidney disease in the elderly.
PG  - e24350
LID - 10.1002/jcla.24350 [doi]
LID - e24350
AB  - OBJECTIVE: To investigate the relationship between serum lutein and type 2 
      diabetes mellitus (T2DM) and diabetic kidney disease (DKD) in elderly 
      individuals. METHODS: A total of 60 T2DM patients over 60 years were subgrouped 
      into a DKD group and a non-DKD group according to their urinary 
      microalbumin-to-creatinine ratio (UACR), while 30 age-matched non-T2DM patients 
      were recruited in the control group. Baseline characteristics, laboratory 
      examination results, and serum lutein levels were compared, and their 
      correlations were analyzed. Receiver operating characteristic (ROC) curves were 
      plotted to identify the diagnostic potential of lutein in T2DM and DKD. RESULTS: 
      The lutein level in the T2DM group was significantly lower than that in the 
      control group and was also significantly lower in the DKD group than in the 
      non-DKD group (p < 0.001). Lutein levels were negatively correlated with body 
      mass index, glycosylated hemoglobin, fasting blood glucose, triglyceride, and 
      UACR and positively correlated with high-density lipoprotein cholesterol 
      (p < 0.05). T2DM patients were divided into four groups according to the quartile 
      of their lutein level. The proportion of T2DM and DKD gradually decreased with 
      increasing lutein levels (p < 0.001). The area under the ROC curve of serum 
      lutein in diagnosing T2DM and DKD was 0.880 and 0.779, respectively, with 
      corresponding cut-off values of 0.433 mumol/L and 0.197 mumol/L (p < 0.001). 
      CONCLUSION: The serum level of lutein is negatively correlated with the incidence 
      of T2DM and DKD in the elderly and can serve as a diagnostic marker for T2DM and 
      DKD.
CI  - (c) 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Pan, Fenghui
AU  - Pan F
AD  - Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Cui, Wenxia
AU  - Cui W
AD  - Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Gao, Lei
AU  - Gao L
AD  - Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Shi, Xiaoting
AU  - Shi X
AD  - Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Yang, Haiyan
AU  - Yang H
AD  - Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Hu, Yun
AU  - Hu Y
AD  - Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, China.
FAU - Li, Man
AU  - Li M
AUID- ORCID: 0000-0001-5328-7322
AD  - Department of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, China.
LA  - eng
GR  - 82003823/The National Natural Science Foundation of China/
GR  - BJ17003/Foundation of Jiangsu Province Health Bureau/
GR  - BJ18008/Foundation of Jiangsu Province Health Bureau/
PT  - Journal Article
DEP - 20220315
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Biomarkers)
RN  - X72A60C9MT (Lutein)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - *Diabetes Mellitus, Type 2
MH  - *Diabetic Nephropathies
MH  - Humans
MH  - Lutein
MH  - ROC Curve
PMC - PMC8993643
OTO - NOTNLM
OT  - biomarker
OT  - diabetic kidney disease
OT  - lutein
OT  - type 2 diabetes mellitus
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2022/03/17 06:00
MHDA- 2022/04/13 06:00
PMCR- 2022/03/15
CRDT- 2022/03/16 05:59
PHST- 2022/02/15 00:00 [revised]
PHST- 2021/12/26 00:00 [received]
PHST- 2022/03/05 00:00 [accepted]
PHST- 2022/03/17 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2022/03/16 05:59 [entrez]
PHST- 2022/03/15 00:00 [pmc-release]
AID - JCLA24350 [pii]
AID - 10.1002/jcla.24350 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2022 Apr;36(4):e24350. doi: 10.1002/jcla.24350. Epub 2022 Mar 
      15.