PMID- 35294197
OWN - NLM
STAT- MEDLINE
DCOM- 20220415
LR  - 20220415
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 38
IP  - 12
DP  - 2022 Mar 29
TI  - PDMS-Zwitterionic Hybrid for Facile, Antifouling Microfluidic Device Fabrication.
PG  - 3775-3784
LID - 10.1021/acs.langmuir.1c03375 [doi]
AB  - Poly(dimethylsiloxane) (PDMS) has been used in a wide range of biomedical devices 
      and medical research due to its biostability, cytocompatibility, gas 
      permeability, and optical properties. Yet, some properties of PDMS create 
      critical limitations, particularly fouling through protein and cell adhesion. In 
      this study, a diallyl-terminated sulfobetaine (SB-diallyl) molecule was 
      synthesized and then directly mixed with a commercial PDMS base (Sylgard 184) and 
      curing agent to produce a zwitterionic group-bearing PDMS (PDMS-SB) hybrid that 
      does not require a complex or an additional surface modification process for the 
      desired end product. In vitro examination of antifouling behavior following 
      exposure to fresh ovine blood showed a significant reduction in platelet 
      deposition for the PDMS-SB hybrid surface compared to that of a PDMS control (p < 
      0.05, n = 5). The manufacturability via soft lithography using the synthesized 
      polymers was found to be comparable to that for unmodified PDMS. Bonding via O(2) 
      plasma treatment was confirmed, and the strength was measured and again found to 
      be comparable to the control. PDMS-SB microfluidic devices were successfully 
      fabricated and showed improved blood compatibility that could reduce channel 
      occlusion due to clot formation relative to PDMS control devices. Further, gas 
      (CO(2)) transfer through a PDMS-SB hybrid membrane was also tested with a 
      proof-of-concept microchannel device and shown to be comparable to that through 
      the PDMS control.
FAU - Mercader, Anthony
AU  - Mercader A
AD  - Department of Mechanical Engineering & Materials Science, University of 
      Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
FAU - Ye, Sang-Ho
AU  - Ye SH
AD  - McGowan Institute for Regenerative Medicine, University of Pittsburgh, 
      Pittsburgh, Pennsylvania 15219, United States.
AD  - Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, 
      United States.
FAU - Kim, Seungil
AU  - Kim S
AD  - McGowan Institute for Regenerative Medicine, University of Pittsburgh, 
      Pittsburgh, Pennsylvania 15219, United States.
AD  - Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, 
      United States.
FAU - Orizondo, Ryan A
AU  - Orizondo RA
AD  - McGowan Institute for Regenerative Medicine, University of Pittsburgh, 
      Pittsburgh, Pennsylvania 15219, United States.
AD  - Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 
      15213, United States.
AD  - Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 
      15213, United States.
FAU - Cho, Sung Kwon
AU  - Cho SK
AUID- ORCID: 0000-0001-7283-8839
AD  - Department of Mechanical Engineering & Materials Science, University of 
      Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
FAU - Wagner, William R
AU  - Wagner WR
AUID- ORCID: 0000-0003-0082-8089
AD  - McGowan Institute for Regenerative Medicine, University of Pittsburgh, 
      Pittsburgh, Pennsylvania 15219, United States.
AD  - Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, 
      United States.
AD  - Department of Chemical and Petroleum Engineering, University of Pittsburgh, 
      Pittsburgh, Pennsylvania 15213, United States.
LA  - eng
GR  - R03 EB023620/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20220316
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Polymers)
SB  - IM
MH  - Animals
MH  - *Biofouling/prevention & control
MH  - Cell Adhesion
MH  - Dimethylpolysiloxanes
MH  - *Lab-On-A-Chip Devices
MH  - Polymers
MH  - Printing
MH  - Sheep
EDAT- 2022/03/17 06:00
MHDA- 2022/04/16 06:00
CRDT- 2022/03/16 17:15
PHST- 2022/03/17 06:00 [pubmed]
PHST- 2022/04/16 06:00 [medline]
PHST- 2022/03/16 17:15 [entrez]
AID - 10.1021/acs.langmuir.1c03375 [doi]
PST - ppublish
SO  - Langmuir. 2022 Mar 29;38(12):3775-3784. doi: 10.1021/acs.langmuir.1c03375. Epub 
      2022 Mar 16.