PMID- 35295132
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220319
IS  - 2673-3080 (Electronic)
IS  - 2673-3080 (Linking)
VI  - 3
DP  - 2021
TI  - Sex-specific Associations Between Type 2 Diabetes Incidence and Exposure to 
      Dioxin and Dioxin-like Pollutants: A Meta-analysis.
PG  - 685840
LID - 10.3389/ftox.2021.685840 [doi]
LID - 685840
AB  - The potential for persistent organic pollutants (POPs), including dioxins and 
      dioxin-like polychlorinated biphenyls (DL-PCBs), to increase the risk of incident 
      diabetes in adults has been extensively studied. However, there is substantial 
      variability in the reported associations both between and within studies. 
      Emerging data from rodent studies suggest that dioxin disrupts glucose 
      homeostasis in a sex-specific manner. Thus, we performed a review and 
      meta-analysis of relevant epidemiological studies to investigate sex differences 
      in associations between dioxin or DL-PCB exposure and type 2 diabetes incidence. 
      Articles that met our selection criteria (n = 81) were organized into the 
      following subcategories: data stratified by sex (n = 13), unstratified data (n = 
      45), and data from only 1 sex (n = 13 male, n = 10 female). We also considered 
      whether exposure occurred either abruptly at high concentrations through a 
      contamination event ("disaster exposure") or chronically at low concentrations 
      ("non-disaster exposure"). There were 8 studies that compared associations 
      between dioxin/DL-PCB exposure and diabetes risk in males versus females within 
      the same population. When all sex-stratified or single-sex studies were 
      considered in the meta-analysis (n = 18), the summary relative risk (RR) for 
      incident diabetes among those exposed relative to reference populations was 1.78 
      (95% CI = 1.37-2.31) and 1.95 (95% CI = 1.56-2.43) for female and males, 
      respectively. However, when we restricted the meta-analysis to disaster-exposed 
      populations, the RR was higher in females than males (2.86 versus 1.59, 
      respectively). In contrast, in non-disaster exposed populations the RR for 
      females was lower than males (1.40 and 2.02, respectively). Our meta-analysis 
      suggests that there are sex differences in the associations between 
      dioxin/DL-PCBs exposure and incident diabetes, and that the mode of exposure 
      modifies these differences.
CI  - Copyright (c) 2022 Gang, Van Allen, Villeneuve, MacDonald and Bruin.
FAU - Gang, Noa
AU  - Gang N
AD  - Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, 
      ON, Canada.
FAU - Van Allen, Kyle
AU  - Van Allen K
AD  - Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, 
      ON, Canada.
FAU - Villeneuve, Paul J
AU  - Villeneuve PJ
AD  - School of Mathematics and Statistics, Carleton University, Ottawa, ON, Canada.
AD  - Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.
FAU - MacDonald, Heather
AU  - MacDonald H
AD  - Health and Biosciences Librarian, MacOdrum Library, Carleton University, Ottawa, 
      ON, Canada.
FAU - Bruin, Jennifer E
AU  - Bruin JE
AD  - Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, 
      ON, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220223
PL  - Switzerland
TA  - Front Toxicol
JT  - Frontiers in toxicology
JID - 101777990
PMC - PMC8915902
OTO - NOTNLM
OT  - dioxin-like polychlorinated biphenyls (DL-PCBs)
OT  - dioxins
OT  - meta-analysis
OT  - persistent organic pollutants
OT  - sex differences
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/18 06:00
MHDA- 2022/03/18 06:01
PMCR- 2022/02/23
CRDT- 2022/03/17 05:05
PHST- 2021/03/25 00:00 [received]
PHST- 2021/12/14 00:00 [accepted]
PHST- 2022/03/17 05:05 [entrez]
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/03/18 06:01 [medline]
PHST- 2022/02/23 00:00 [pmc-release]
AID - 685840 [pii]
AID - 10.3389/ftox.2021.685840 [doi]
PST - epublish
SO  - Front Toxicol. 2022 Feb 23;3:685840. doi: 10.3389/ftox.2021.685840. eCollection 
      2021.