PMID- 35295159
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220319
IS  - 2673-3080 (Electronic)
IS  - 2673-3080 (Linking)
VI  - 3
DP  - 2021
TI  - Impact of Quantisal((R)) Oral Fluid Collection Device on Drug Stability.
PG  - 670656
LID - 10.3389/ftox.2021.670656 [doi]
LID - 670656
AB  - The stability of drugs can affect drug tests and interpretations. A comprehensive 
      study to verify drug stability in Quantisal((R)) oral fluid (OF) collection device 
      was undertaken in accordance with Australian standard, AS/NZS 4760:2019 
      (SAI-Global, 2019). The evaluation was performed for the following drugs: (+/-) 
      amphetamine, (+/-) methylamphetamine, (+/-) 3,4-methylenedioxymethylamphetamine 
      (MDMA), (-)Delta9-tetrahydrocannabinol (THC), cocaine, benzoylecgonine, morphine, 
      codeine, and oxycodone. Stability was assessed at four different storage 
      temperatures over seven time points at +/-50% cut-off concentrations (Appendix A, 
      Para A4-4.1, AS/NZS 4760:2019) (SAI-Global, 2019). All drugs were found to be 
      significantly more stable at 4 and -20 degrees C, with stability spanning at least 14 
      days with percentage change within +/-20% from the cut-off concentrations 
      (SAI-Global, 2019). In addition, we report a variation trend with cocaine and 
      benzoylecgonine at elevated temperatures, suggesting hydrolytic decomposition of 
      cocaine and a concomitant increase in benzoylecgonine quantitative values. We 
      confirm the cross-talk by showing that the percentage change in the profile of 
      average cocaine-benzoylecgonine measurement is within the acceptance 
      concentration range of +/-20%. This finding highlights the importance of precaution 
      during storage and careful considerations during subsequent interpretation of 
      liquid chromatography-mass spectrometry (LCMS) measurements.
CI  - Copyright (c) 2021 Riggio, Dave, Koscak, Blakey and Appleton.
FAU - Riggio, Michela
AU  - Riggio M
AD  - Central Laboratories, Toxicology, Biochemistry Queensland Medical Laboratory 
      (QML) Pathology, Brisbane, QLD, Australia.
FAU - Dave, Keyur A
AU  - Dave KA
AD  - Central Laboratories, Toxicology, Biochemistry Queensland Medical Laboratory 
      (QML) Pathology, Brisbane, QLD, Australia.
FAU - Koscak, Branko
AU  - Koscak B
AD  - Central Laboratories, Toxicology, Biochemistry Queensland Medical Laboratory 
      (QML) Pathology, Brisbane, QLD, Australia.
FAU - Blakey, Mark
AU  - Blakey M
AD  - Central Laboratories, Toxicology, Biochemistry Queensland Medical Laboratory 
      (QML) Pathology, Brisbane, QLD, Australia.
FAU - Appleton, Charles
AU  - Appleton C
AD  - Central Laboratories, Toxicology, Biochemistry Queensland Medical Laboratory 
      (QML) Pathology, Brisbane, QLD, Australia.
LA  - eng
PT  - Journal Article
DEP - 20210705
PL  - Switzerland
TA  - Front Toxicol
JT  - Frontiers in toxicology
JID - 101777990
PMC - PMC8915805
OTO - NOTNLM
OT  - collection device
OT  - drugs of abuse
OT  - mass spectrometry
OT  - oral fluid
OT  - quantisal
COIS- The authors were employed by company Queensland Medical Laboratory (QML) 
      Pathology, under the Healius Pathology Pty Ltd network. QML Pathology has a 
      commercial supplier/customer relationship with Abbott Diagnostics for supply of 
      laboratory reagents, analysers, etc as the laboratory does with many other 
      suppliers. Abbott Diagnostics assisted by providing collection and transportation 
      devices and by recompensing the laboratory for cost of consumables required to 
      perform the validation. This had no influence on the performance of the 
      investigation or the conclusions reached.
EDAT- 2022/03/18 06:00
MHDA- 2022/03/18 06:01
PMCR- 2021/07/05
CRDT- 2022/03/17 05:05
PHST- 2021/02/22 00:00 [received]
PHST- 2021/05/31 00:00 [accepted]
PHST- 2022/03/17 05:05 [entrez]
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/03/18 06:01 [medline]
PHST- 2021/07/05 00:00 [pmc-release]
AID - 10.3389/ftox.2021.670656 [doi]
PST - epublish
SO  - Front Toxicol. 2021 Jul 5;3:670656. doi: 10.3389/ftox.2021.670656. eCollection 
      2021.