PMID- 35295603
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220319
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 9
DP  - 2022
TI  - Case Report: Allogenic Simple Limbal Epithelial Transplantation From a Human 
      Leukocyte Antigen-Matched Living Related Donor to Treat Bilateral Corneal 
      Chemical Burns Post Laser-Assisted in situ Keratomileusis.
PG  - 849791
LID - 10.3389/fmed.2022.849791 [doi]
LID - 849791
AB  - A 35-year-old woman who had undergone laser-assisted in situ keratomileusis in 
      both eyes experienced bilateral total limbal stem cell deficiency (LSCD) due to 
      chemical burns. Due to bilateral severe LSCD, allogenic simple limbal epithelial 
      transplantation (SLET) from a human leukocyte antigen (HLA)-matched living 
      related donor was the first choice of treatment for her left eye. We report the 
      first case of HLA or ABO matching living related allogenic SLET for permanent 
      restoration of the cornea for bilateral LSCD treatment. Our ABO-HLA-matched 
      living related allogenic SLET alleviation of the systemic immunosuppressant to 
      topical corticosteroids alone. It also came the limitations of prolonged systemic 
      immunosuppressant usage in conjunctival-limbal allografts and keratolimbal 
      allograft.
CI  - Copyright (c) 2022 Chang, Chan, Jan and Tseng.
FAU - Chang, Yuh-Shin
AU  - Chang YS
AD  - Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.
AD  - Graduate Institute of Medical Science, College of Health Science, Chang Jung 
      Christian University, Tainan, Taiwan.
FAU - Chan, Tsung-Yueh
AU  - Chan TY
AD  - Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.
AD  - Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
FAU - Jan, Ren-Long
AU  - Jan RL
AD  - Graduate Institute of Medical Science, College of Health Science, Chang Jung 
      Christian University, Tainan, Taiwan.
AD  - Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
FAU - Tseng, Sung-Huei
AU  - Tseng SH
AD  - Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.
AD  - Department of Ophthalmology, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
LA  - eng
PT  - Case Reports
DEP - 20220225
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8919960
OTO - NOTNLM
OT  - allogenic simple limbal epithelial transplantation
OT  - bilateral limbal stem cell deficiency
OT  - chemical burns
OT  - human leukocyte antigen-matched living related donor
OT  - laser-assisted in situ keratomileusis
OT  - systemic immunosuppressant
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/18 06:00
MHDA- 2022/03/18 06:01
PMCR- 2022/02/25
CRDT- 2022/03/17 05:10
PHST- 2022/01/06 00:00 [received]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2022/03/17 05:10 [entrez]
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/03/18 06:01 [medline]
PHST- 2022/02/25 00:00 [pmc-release]
AID - 10.3389/fmed.2022.849791 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Feb 25;9:849791. doi: 10.3389/fmed.2022.849791. 
      eCollection 2022.