PMID- 35295800
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220319
IS  - 2673-561X (Electronic)
IS  - 2673-561X (Print)
IS  - 2673-561X (Linking)
VI  - 3
DP  - 2022
TI  - Algometer Assessment of Pressure Pain Threshold After Onabotulinumtoxin-A and 
      Physical Therapy Treatments in Patients With Chronic Migraine: An Observational 
      Study.
PG  - 770397
LID - 10.3389/fpain.2022.770397 [doi]
LID - 770397
AB  - The purpose of this study was to evaluate pain hypersensitivity in chronic 
      migraine patients 3 months after undergoing onabotulinumtoxin-A therapy, physical 
      therapy (PT), or the combination of the two. Pressure pain threshold (PPT) was 
      assessed in accordance with Andersen's guidelines, focusing on five muscles in 
      the trigeminocervical area (namely, trapezius, levator scapulae, temporalis, 
      sub-occipitalis, and scalenus medius) and one muscle outside of the area, (i.e., 
      tensor fasciae latae). Moreover, three headache parameters, namely, attack 
      frequency, duration, and pain intensity, were recorded in an ad hoc diary kept by 
      the patients. A total of 30 patients were included in three treatment groups: 1. 
      onabotulinumtoxin-A therapy, 2. PT, and 3. a combination of onabotulinumtoxin-A 
      and PT. The results show that, at the final assessment, the PPT was significantly 
      reduced in the combined treatment group compared to the two single-therapy 
      groups. As regards headache parameters, frequency and duration of the attacks 
      were decreased significantly in all three treatment groups, whereas in pain 
      intensity, the reduction was statistically significant in the combined treatment 
      group and the onabotulinumtoxin-A therapy. Results suggest that a better pain 
      modulation in patients with chronic migraine can be achieved with a combined 
      treatment of onabotulinumtoxin-A and physical therapy. Indeed, the combination of 
      both pharmacological and non-pharmacological treatments results in the reduction 
      of both headache-related parameters and widespread pressure hyperalgesia.
CI  - Copyright (c) 2022 Deodato, Granato, Ceschin, Galmonte and Manganotti.
FAU - Deodato, Manuela
AU  - Deodato M
AD  - Department of Medical, Surgical and Health Sciences, University of Trieste, 
      Trieste, Italy.
AD  - Department of Life Sciences, University of Trieste, Trieste, Italy.
AD  - Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
FAU - Granato, Antonio
AU  - Granato A
AD  - Department of Medical, Surgical and Health Sciences, University of Trieste, 
      Trieste, Italy.
AD  - Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
FAU - Ceschin, Marta
AU  - Ceschin M
AD  - Department of Medical, Surgical and Health Sciences, University of Trieste, 
      Trieste, Italy.
FAU - Galmonte, Alessandra
AU  - Galmonte A
AD  - Department of Medical, Surgical and Health Sciences, University of Trieste, 
      Trieste, Italy.
FAU - Manganotti, Paolo
AU  - Manganotti P
AD  - Department of Medical, Surgical and Health Sciences, University of Trieste, 
      Trieste, Italy.
AD  - Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220210
PL  - Switzerland
TA  - Front Pain Res (Lausanne)
JT  - Frontiers in pain research (Lausanne, Switzerland)
JID - 9918227269806676
PMC - PMC8915742
OTO - NOTNLM
OT  - algometer
OT  - central sensitization
OT  - chronic migraine
OT  - onabotulinumtoxin-A
OT  - physical therapy
OT  - pressure pain threshold
OT  - trigeminal area
OT  - widespread pressure hyperalgesia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/18 06:00
MHDA- 2022/03/18 06:01
PMCR- 2022/02/10
CRDT- 2022/03/17 05:14
PHST- 2021/09/03 00:00 [received]
PHST- 2022/01/10 00:00 [accepted]
PHST- 2022/03/17 05:14 [entrez]
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/03/18 06:01 [medline]
PHST- 2022/02/10 00:00 [pmc-release]
AID - 10.3389/fpain.2022.770397 [doi]
PST - epublish
SO  - Front Pain Res (Lausanne). 2022 Feb 10;3:770397. doi: 10.3389/fpain.2022.770397. 
      eCollection 2022.