PMID- 35295812
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220319
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 25
IP  - 3
DP  - 2022 Mar 18
TI  - The role of long noncoding RNA Nron in atherosclerosis development and plaque 
      stability.
PG  - 103978
LID - 10.1016/j.isci.2022.103978 [doi]
LID - 103978
AB  - The major clinical consequences of atherosclerosis such as myocardial infarction 
      or stroke are because of thrombotic events associated with acute rupture or 
      erosion of an unstable plaque. Here, we identify an lncRNA Noncoding Repressor of 
      NFAT (Nron) as a critical regulator of atherosclerotic plaque stability. Nron 
      overexpression (OE) in vascular smooth muscle cells (VSMC) induces a highly 
      characteristic architecture of more-vulnerable plaques, while Nron knockdown (KD) 
      suppresses the development of atherosclerosis and favors plaque stability. 
      Mechanistically, Nron specifically binds to and negatively regulates NFATc3, thus 
      inhibiting the proliferation and promoting the apoptosis of VSMCs. Moreover, we 
      also provide evidence that Nron increases the production and secretion of VEGFA 
      from VSMCs, which functions as a paracrine factor to enhance intra-plaque 
      angiogenesis. All of these effects contribute to plaque instability. Genetic or 
      pharmacological inhibition of Nron may have potential for future therapy of 
      atherosclerosis.
CI  - (c) 2022 The Authors.
FAU - Du, Meng
AU  - Du M
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
AD  - Liyuan Cardiovascular Center, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, China.
FAU - Wang, Cheng
AU  - Wang C
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Yang, Liuye
AU  - Yang L
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Liu, Bing
AU  - Liu B
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Zheng, Zhe
AU  - Zheng Z
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Yang, Liu
AU  - Yang L
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Zhang, Fengxiao
AU  - Zhang F
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Peng, Jiangtong
AU  - Peng J
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Huang, Dan
AU  - Huang D
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Huang, Kai
AU  - Huang K
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, 1277 Jiefang Ave., Wuhan 430000 China.
AD  - Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
AD  - Liyuan Cardiovascular Center, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, China.
LA  - eng
PT  - Journal Article
DEP - 20220224
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC8919297
OTO - NOTNLM
OT  - Functional aspects of cell biology
OT  - Molecular biology
OT  - Pathophysiology
COIS- The authors declare no potential conflicts of interest.
EDAT- 2022/03/18 06:00
MHDA- 2022/03/18 06:01
PMCR- 2022/02/24
CRDT- 2022/03/17 05:14
PHST- 2021/09/27 00:00 [received]
PHST- 2021/12/31 00:00 [revised]
PHST- 2022/02/21 00:00 [accepted]
PHST- 2022/03/17 05:14 [entrez]
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/03/18 06:01 [medline]
PHST- 2022/02/24 00:00 [pmc-release]
AID - S2589-0042(22)00248-6 [pii]
AID - 103978 [pii]
AID - 10.1016/j.isci.2022.103978 [doi]
PST - epublish
SO  - iScience. 2022 Feb 24;25(3):103978. doi: 10.1016/j.isci.2022.103978. eCollection 
      2022 Mar 18.