PMID- 35296444
OWN - NLM
STAT- MEDLINE
DCOM- 20220510
LR  - 20220517
IS  - 1878-7568 (Electronic)
IS  - 1742-7061 (Linking)
VI  - 144
DP  - 2022 May
TI  - A biomimetic zeolite-based nanoenzyme contributes to neuroprotection in the 
      neurovascular unit after ischaemic stroke via efficient removal of zinc and ROS.
PG  - 142-156
LID - S1742-7061(22)00149-0 [pii]
LID - 10.1016/j.actbio.2022.03.018 [doi]
AB  - Zeolite-based nanomaterials have a large number of applications in the field of 
      medicine due to their high porosity, biocompatibility and biological stability. 
      In this study, we designed cerium (Ce)-doped Linde Type A (LTA) zeolite-based 
      nanomaterials (Ce/Zeo-NMs) as a multifunctional mesoporous nanoenzyme to reduce 
      dysfunction of the neurovascular unit (NVU) and attenuate cerebral 
      ischaemia-reperfusion (I/R) injury. Owing to its unique adsorption capacity and 
      mimetic catalytic activities, Ce@Zeo-NMs adsorbed excess zinc ions and exhibited 
      scavenging activity against reactive oxygen species (ROS) induced by acute I/R, 
      thus reshaping the oxidative and zinc microenvironment in the ischaemic brain. In 
      vivo results demonstrated that Ce@Zeo-NMs significantly reduced ischaemic damage 
      to the NVU by decreasing the infarct area, protecting against breakdown of the 
      blood-brain barrier (BBB) via inhibiting the degradation of tight junction 
      proteins (TJPs) and inhibiting activation of microglia and astrocytes in a rat 
      model of middle cerebral artery occlusion-reperfusion (MCAO/R). Taken together, 
      these findings indicated that Ce@Zeo-NMs may serve as a promising dual-targeting 
      therapeutic agent for alleviating cerebral I/R injury. STATEMENT OF SIGNIFICANCE: 
      Cerium (Ce)-doped Linde Type A zeolite-based nanomaterials (Ce/Zeo-NMs) as a 
      multifunctional mesoporous nanoenzyme were designed for inducing neuroprotection 
      after ischaemic stroke by reducing dysfunction of the neurovascular unit (NVU). 
      Ce@Zeo-NMs had the ability to adsorb excessive Zn(2+) and showed mimetic 
      enzymatic activities. As a result, Ce@Zeo-NMs protected against cerebral 
      ischaemia and reduced the damage of NVU by improving the integrity of blood brain 
      barrier (BBB) and inhibiting activation of microglia and astrocytes in a rat 
      model of middle cerebral artery occlusion-reperfusion (MCAO/R). These findings 
      indicated that Ce@Zeo-NMs may serve as a therapeutic strategy for neuroprotection 
      and functional recovery upon ischaemic stroke onset.
CI  - Copyright (c) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights 
      reserved.
FAU - Huang, Zhixuan
AU  - Huang Z
AD  - School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, China.
FAU - Qian, Kun
AU  - Qian K
AD  - Department of Chemistry, Jinzhou Medical University, Jinzhou, 121000, China.
FAU - Chen, Jin
AU  - Chen J
AD  - School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, China.
FAU - Qi, Yao
AU  - Qi Y
AD  - School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, China.
FAU - E, Yifeng
AU  - E Y
AD  - School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, China.
FAU - Liang, Jia
AU  - Liang J
AD  - Life Science Institution, Jinzhou Medical University, Jinzhou 121000, China. 
      Electronic address: liangjia@jzmu.edu.cn.
FAU - Zhao, Liang
AU  - Zhao L
AD  - School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, China. Electronic 
      address: liangzhao79@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220314
PL  - England
TA  - Acta Biomater
JT  - Acta biomaterialia
JID - 101233144
RN  - 0 (Reactive Oxygen Species)
RN  - 1318-02-1 (Zeolites)
RN  - 30K4522N6T (Cerium)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Biomimetics
MH  - Blood-Brain Barrier/metabolism
MH  - *Brain Ischemia/drug therapy
MH  - *Cerium/pharmacology
MH  - Infarction, Middle Cerebral Artery/complications/drug therapy/metabolism
MH  - *Ischemic Stroke
MH  - Neuroprotection
MH  - Rats
MH  - Reactive Oxygen Species/metabolism
MH  - *Reperfusion Injury/drug therapy
MH  - *Stroke/drug therapy
MH  - *Zeolites/metabolism/pharmacology/therapeutic use
MH  - Zinc/metabolism
OTO - NOTNLM
OT  - Cerium
OT  - Nanoenzyme
OT  - Nanoparticles
OT  - ROS
OT  - Zeolite
OT  - Zinc
COIS- Declaration of Competing Interest The authors report no conflicts of interest in 
      this work.
EDAT- 2022/03/18 06:00
MHDA- 2022/05/11 06:00
CRDT- 2022/03/17 05:30
PHST- 2021/10/21 00:00 [received]
PHST- 2022/03/04 00:00 [revised]
PHST- 2022/03/08 00:00 [accepted]
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/05/11 06:00 [medline]
PHST- 2022/03/17 05:30 [entrez]
AID - S1742-7061(22)00149-0 [pii]
AID - 10.1016/j.actbio.2022.03.018 [doi]
PST - ppublish
SO  - Acta Biomater. 2022 May;144:142-156. doi: 10.1016/j.actbio.2022.03.018. Epub 2022 
      Mar 14.