PMID- 35296645
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221023
IS  - 2095-4700 (Print)
IS  - 2095-6231 (Electronic)
IS  - 2095-4700 (Linking)
VI  - 10
IP  - 1
DP  - 2022 Mar 16
TI  - Versatile subtypes of pericytes and their roles in spinal cord injury repair, 
      bone development and repair.
PG  - 30
LID - 10.1038/s41413-022-00203-2 [doi]
LID - 30
AB  - Vascular regeneration is a challenging topic in tissue repair. As one of the 
      important components of the neurovascular unit (NVU), pericytes play an essential 
      role in the maintenance of the vascular network of the spinal cord. To date, 
      subtypes of pericytes have been identified by various markers, namely the 
      PDGFR-beta, Desmin, CD146, and NG2, each of which is involved with spinal cord 
      injury (SCI) repair. In addition, pericytes may act as a stem cell source that is 
      important for bone development and regeneration, whilst specific subtypes of 
      pericyte could facilitate bone fracture and defect repair. One of the major 
      challenges of pericyte biology is to determine the specific markers that would 
      clearly distinguish the different subtypes of pericytes, and to develop efficient 
      approaches to isolate and propagate pericytes. In this review, we discuss the 
      biology and roles of pericytes, their markers for identification, and cell 
      differentiation capacity with a focus on the potential application in the 
      treatment of SCI and bone diseases in orthopedics.
CI  - (c) 2022. The Author(s).
FAU - Zhu, Sipin
AU  - Zhu S
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
AD  - Molecular Pharmacology Research Centre, School of Pharmaceutical Sciences, 
      Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
AD  - Molecular Laboratory, School of Biomedical Sciences, The University of Western 
      Australia, Perth, WA, 6009, Australia.
FAU - Chen, Min
AU  - Chen M
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
FAU - Ying, Yibo
AU  - Ying Y
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
FAU - Wu, Qiuji
AU  - Wu Q
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
FAU - Huang, Zhiyang
AU  - Huang Z
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
FAU - Ni, Wenfei
AU  - Ni W
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
FAU - Wang, Xiangyang
AU  - Wang X
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
FAU - Xu, Huazi
AU  - Xu H
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
FAU - Bennett, Samuel
AU  - Bennett S
AD  - Molecular Laboratory, School of Biomedical Sciences, The University of Western 
      Australia, Perth, WA, 6009, Australia.
FAU - Xiao, Jian
AU  - Xiao J
AUID- ORCID: 0000-0001-7374-6506
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. 
      xfxj2000@126.com.
AD  - Molecular Pharmacology Research Centre, School of Pharmaceutical Sciences, 
      Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. xfxj2000@126.com.
FAU - Xu, Jiake
AU  - Xu J
AUID- ORCID: 0000-0003-2021-8309
AD  - Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. 
      jiake.xu@uwa.edu.au.
AD  - Molecular Laboratory, School of Biomedical Sciences, The University of Western 
      Australia, Perth, WA, 6009, Australia. jiake.xu@uwa.edu.au.
LA  - eng
GR  - 81722028/National Natural Science Foundation of China (National Science 
      Foundation of China)/
PT  - Journal Article
PT  - Review
DEP - 20220316
PL  - China
TA  - Bone Res
JT  - Bone research
JID - 101608652
PMC - PMC8927336
COIS- All authors declare no competing interests.
EDAT- 2022/03/18 06:00
MHDA- 2022/03/18 06:01
PMCR- 2022/03/16
CRDT- 2022/03/17 05:31
PHST- 2020/11/17 00:00 [received]
PHST- 2022/01/17 00:00 [accepted]
PHST- 2021/12/16 00:00 [revised]
PHST- 2022/03/17 05:31 [entrez]
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/03/18 06:01 [medline]
PHST- 2022/03/16 00:00 [pmc-release]
AID - 10.1038/s41413-022-00203-2 [pii]
AID - 203 [pii]
AID - 10.1038/s41413-022-00203-2 [doi]
PST - epublish
SO  - Bone Res. 2022 Mar 16;10(1):30. doi: 10.1038/s41413-022-00203-2.