PMID- 35296975
OWN - NLM
STAT- MEDLINE
DCOM- 20230203
LR  - 20230203
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 192
IP  - 1
DP  - 2023 Feb
TI  - Effects of acute aerobic exercise on cytokines, klotho, irisin, and vascular 
      endothelial growth factor responses in rheumatoid arthritis patients.
PG  - 491-497
LID - 10.1007/s11845-022-02970-7 [doi]
AB  - BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease 
      that causes cartilage and bone damage as well as disability.  AIMS : The aim of 
      this study was to examine the effects of acute aerobic exercise on cytokines such 
      as serum interleukin-6 (IL-6), interleukin-1beta (IL-1beta), Tumor Necrosis Factor-alpha 
      (TNF-alpha) and irisin, vascular endothelial growth factor(VEGF) and klotho in RA 
      patients.  METHODS: Forty RA patient and 40 healthy volunteers of the same age 
      participated in this study. All participants walked on the treadmill for 30 
      minutes at 60-80% of maximal heart rate. Blood samples were taken before and 
      immediately after the exercise. Serum levels of IL-6, IL1beta, TNF-alpha and irisin, 
      VEGF and klotho were measured by enzyme-linked immunosorbent analysis.  RESULTS: 
      Baseline levels of inflammatory cytokines, irisin, VEGF and klotho were found to 
      be higher in RA patients compared to the control group. In both groups, there was 
      an increase in serum klotho levels after exercise compared to baseline (p<0.05), 
      while a decrease in IL1beta, TNF-alpha levels were observed. While serum VEGF level 
      decreased in RA group, it increased in the control group(p<0.05). Irisin levels 
      decreased in both groups. IL-6 level did not change in the control group, while 
      it increased in RA group. A single exercise session had an acute 
      anti-inflammatory effect in RA patients. CONCLUSION: It can be concluded that 
      acute aerobic exercise can be beneficial for patients with RA through cytokine, 
      irisin, klotho and VEGF levels, and also it can be safely implemented to the RA 
      rehabilitation program for additional anti-inflammatory effects. Trial 
      registration ClinicalTrials.gov: NCT04439682.
CI  - (c) 2022. The Author(s), under exclusive licence to Royal Academy of Medicine in 
      Ireland.
FAU - Ercan, Zubeyde
AU  - Ercan Z
AD  - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Firat 
      University, Elazig, Turkey. zubeydeercan@firat.edu.tr.
FAU - Deniz, Gulnihal
AU  - Deniz G
AD  - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, 
      Erzurum Technical University, Erzurum, Turkey.
FAU - Yentur, Songul Baglan
AU  - Yentur SB
AD  - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Firat 
      University, Elazig, Turkey.
FAU - Arikan, Funda Bulut
AU  - Arikan FB
AD  - Department of Physiology, Faculty of Medicine, Kirikkale University, Kirikkale, 
      Turkey.
FAU - Karatas, Ahmet
AU  - Karatas A
AD  - Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, 
      Turkey.
FAU - Alkan, Gokhan
AU  - Alkan G
AD  - Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Firat 
      University, Elazig, Turkey.
FAU - Koca, Suleyman Serdar
AU  - Koca SS
AD  - Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, 
      Turkey.
LA  - eng
SI  - ClinicalTrials.gov/NCT04439682
GR  - SYO.20.01/Firat University Scientific Research Projects Foundation/
PT  - Journal Article
DEP - 20220316
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
RN  - 0 (Cytokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Fibronectins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Humans
MH  - *Cytokines/therapeutic use
MH  - Vascular Endothelial Growth Factor A
MH  - Fibronectins
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Interleukin-6
MH  - *Arthritis, Rheumatoid
MH  - Vascular Endothelial Growth Factors/therapeutic use
MH  - Exercise
MH  - Anti-Inflammatory Agents/therapeutic use
OTO - NOTNLM
OT  - Acute aerobic exercise
OT  - Cytokine
OT  - Irisin
OT  - Klotho
OT  - Rheumatoid arthritis
OT  - VEGF
EDAT- 2022/03/18 06:00
MHDA- 2023/02/04 06:00
CRDT- 2022/03/17 05:34
PHST- 2022/02/02 00:00 [received]
PHST- 2022/03/09 00:00 [accepted]
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2023/02/04 06:00 [medline]
PHST- 2022/03/17 05:34 [entrez]
AID - 10.1007/s11845-022-02970-7 [pii]
AID - 10.1007/s11845-022-02970-7 [doi]
PST - ppublish
SO  - Ir J Med Sci. 2023 Feb;192(1):491-497. doi: 10.1007/s11845-022-02970-7. Epub 2022 
      Mar 16.