PMID- 35297063
OWN - NLM
STAT- MEDLINE
DCOM- 20220510
LR  - 20220616
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 62
IP  - 5
DP  - 2022 May
TI  - Relationship between allergic transfusion reactions and allergic predisposition 
      among pediatric patients with hematological/oncological disease.
PG  - 1035-1044
LID - 10.1111/trf.16855 [doi]
AB  - BACKGROUND: Allergic transfusion reactions (ATRs) manifest frequently as 
      transfusion reactions, and their onset may be related to a patient's allergic 
      predisposition. Moreover, although pediatric patients with 
      hematological/oncological disease are more susceptible to ATRs, the relationship 
      between allergic predisposition and ATRs remains to be fully clarified. STUDY 
      DESIGN AND METHODS: Patients who were diagnosed with pediatric 
      hematological/oncological disease and received transfusion at the study 
      institutions were included. We determined patient background information related 
      to their allergy history, measured the levels of allergen-specific immunoglobulin 
      E (IgE) using sera obtained on diagnosis, and analyzed their associations with 
      ATR onset. RESULTS: Of the 363 patients analyzed, 144 developed ATRs. 
      Multivariate analysis identified cases with high basophils in the peripheral 
      blood, and Dermatophagoides pteronyssinus- and egg white-specific IgEs were 
      involved in the development of ATR in all age groups. Meanwhile, a history of 
      food allergies, and positivity for Japanese cypress- and D. 
      pteronyssinus-specific IgEs were risk factors for developing ATRs in the <5 years 
      age group. Moreover, patients aged 5-<10 years with a history of asthma, allergic 
      rhinitis, pollinosis, or atopic dermatitis, and those aged >/=10 years with 
      positivity for dog dander-specific IgE were at risk for developing ATRs. 
      CONCLUSION: The allergic constitution of patients plays a role in ATR onset even 
      in pediatric hematological/oncological diseases. Therefore, advance confirmation 
      of a patient's allergic constitution may partly predict the onset of ATRs. 
      However, since multiple allergic predispositions within complex mechanisms may be 
      involved in the onset of ATRs, further verification is required.
CI  - (c) 2022 AABB.
FAU - Yanagisawa, Ryu
AU  - Yanagisawa R
AUID- ORCID: 0000-0003-4012-0958
AD  - Division of Blood Transfusion, Shinshu University Hospital, Matsumoto, Japan.
AD  - Center for Advanced Cell Therapy, Shinshu University Hospital, Matsumoto, Japan.
AD  - Life Science Research Center, Nagano Children's Hospital, Azumino, Japan.
FAU - Ishimine, Nau
AU  - Ishimine N
AD  - Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
FAU - Komori, Kazutoshi
AU  - Komori K
AD  - Department of Hematology and Oncology, Nagano Children's Hospital, Azumino, 
      Japan.
FAU - Kurata, Takashi
AU  - Kurata T
AD  - Department of Hematology and Oncology, Nagano Children's Hospital, Azumino, 
      Japan.
FAU - Saito, Shoji
AU  - Saito S
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Tanaka, Miyuki
AU  - Tanaka M
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
FAU - Sakashita, Kazuo
AU  - Sakashita K
AD  - Life Science Research Center, Nagano Children's Hospital, Azumino, Japan.
AD  - Department of Hematology and Oncology, Nagano Children's Hospital, Azumino, 
      Japan.
FAU - Tozuka, Minoru
AU  - Tozuka M
AD  - Life Science Research Center, Nagano Children's Hospital, Azumino, Japan.
AD  - Department of Laboratory Medicine, Nagano Children's Hospital, Azumino, Japan.
FAU - Nakazawa, Yozo
AU  - Nakazawa Y
AUID- ORCID: 0000-0003-0793-815X
AD  - Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20220316
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Basophils
MH  - Child
MH  - Disease Susceptibility/complications
MH  - Dogs
MH  - Humans
MH  - *Hypersensitivity/etiology
MH  - Immunoglobulin E/analysis
MH  - Risk Factors
MH  - *Transfusion Reaction/complications
OTO - NOTNLM
OT  - allergic rhinitis
OT  - allergic sensitization
OT  - asthma
OT  - atopic dermatitis
OT  - hay fever
OT  - pollinosis
EDAT- 2022/03/18 06:00
MHDA- 2022/05/11 06:00
CRDT- 2022/03/17 05:35
PHST- 2022/02/03 00:00 [revised]
PHST- 2021/12/14 00:00 [received]
PHST- 2022/03/06 00:00 [accepted]
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/05/11 06:00 [medline]
PHST- 2022/03/17 05:35 [entrez]
AID - 10.1111/trf.16855 [doi]
PST - ppublish
SO  - Transfusion. 2022 May;62(5):1035-1044. doi: 10.1111/trf.16855. Epub 2022 Mar 16.