PMID- 35298121
OWN - NLM
STAT- MEDLINE
DCOM- 20221111
LR  - 20221222
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Print)
IS  - 1936-0851 (Linking)
VI  - 16
IP  - 4
DP  - 2022 Apr 26
TI  - Pushing the Limits on the Intestinal Crossing of Metal-Organic Frameworks: An Ex 
      Vivo and In Vivo Detailed Study.
PG  - 5830-5838
LID - 10.1021/acsnano.1c10942 [doi]
AB  - Biocompatible nanoscaled metal-organic frameworks (nanoMOFs) have been widely 
      studied as drug delivery systems (DDSs), through different administration routes, 
      with rare examples in the convenient and commonly used oral administration. So 
      far, the main objective of nanoMOFs as oral DDSs was to increase the 
      bioavailability of the cargo, without considering the MOF intestinal crossing 
      with potential advantages (e.g., increasing drug availability, direct transport 
      to systemic circulation). Thus, we propose to address the direct quantification 
      and visualization of MOFs' intestinal bypass. For that purpose, we select the 
      microporous Fe-based nanoMOF, MIL-127, exhibiting interesting properties as a 
      nanocarrier (great biocompatibility, large porosity accessible to different 
      drugs, green and multigram scale synthesis, outstanding stability along the 
      gastrointestinal tract). Additionally, the outer surface of MIL-127 was 
      engineered with the biopolymer chitosan (CS@MIL-127) to improve the nanoMOF 
      intestinal permeation. The biocompatibility and intestinal crossing of nanoMOFs 
      is confirmed using a simple and relevant in vivo model, Caenorhabditis elegans; 
      these worms are able to ingest enormous amounts of nanoMOFs (up to 35 g per kg of 
      body weight). Finally, an ex vivo intestinal model (rat) is used to further 
      support the nanoMOFs' bypass across the intestinal barrier, demonstrating a fast 
      crossing (only 2 h). To the best of our knowledge, this report on the intestinal 
      crossing of intact nanoMOFs sheds light on the safe and efficient application of 
      MOFs as oral DDSs.
FAU - Rojas, Sara
AU  - Rojas S
AUID- ORCID: 0000-0002-7874-2122
AD  - Advanced Porous Materials Unit (APMU), IMDEA Energy Institute, Av. Ramon de la 
      Sagra 3, 28935 Mostoles-Madrid, Spain.
FAU - Hidalgo, Tania
AU  - Hidalgo T
AUID- ORCID: 0000-0002-3498-9967
AD  - Advanced Porous Materials Unit (APMU), IMDEA Energy Institute, Av. Ramon de la 
      Sagra 3, 28935 Mostoles-Madrid, Spain.
FAU - Luo, Zhongrui
AU  - Luo Z
AD  - Institut de Ciencia de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193 
      Bellaterra, Spain.
FAU - Avila, David
AU  - Avila D
AD  - Department of Inorganic Chemistry, Chemical Sciences Faculty, Complutense 
      University of Madrid, 28040 Madrid, Spain.
FAU - Laromaine, Anna
AU  - Laromaine A
AUID- ORCID: 0000-0002-4764-0780
AD  - Institut de Ciencia de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193 
      Bellaterra, Spain.
FAU - Horcajada, Patricia
AU  - Horcajada P
AUID- ORCID: 0000-0002-6544-5911
AD  - Advanced Porous Materials Unit (APMU), IMDEA Energy Institute, Av. Ramon de la 
      Sagra 3, 28935 Mostoles-Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220317
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - 0 (Metal-Organic Frameworks)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Metal-Organic Frameworks
MH  - Drug Delivery Systems
MH  - Porosity
MH  - *Chitosan
MH  - Administration, Oral
PMC - PMC9047668
OTO - NOTNLM
OT  - Bioavailability
OT  - Caenorhabditis elegans
OT  - Chitosan
OT  - Intestinal Permeability
OT  - Metal-Organic Frameworks
COIS- The authors declare no competing financial interest.
EDAT- 2022/03/18 06:00
MHDA- 2022/11/15 06:00
PMCR- 2022/04/28
CRDT- 2022/03/17 17:16
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/03/17 17:16 [entrez]
PHST- 2022/04/28 00:00 [pmc-release]
AID - 10.1021/acsnano.1c10942 [doi]
PST - ppublish
SO  - ACS Nano. 2022 Apr 26;16(4):5830-5838. doi: 10.1021/acsnano.1c10942. Epub 2022 
      Mar 17.