PMID- 35298140
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220407
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 14
IP  - 12
DP  - 2022 Mar 30
TI  - Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes 
      Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration.
PG  - 14059-14071
LID - 10.1021/acsami.1c24569 [doi]
AB  - Diabetic foot ulcer is a serious complication in diabetes patients, imposing a 
      serious physical and economic burden to patients and to the healthcare system as 
      a whole. Oxidative stress is thought to be a key driver of the pathogenesis of 
      such ulcers. However, no antioxidant drugs have received clinical approval to 
      date, underscoring the need for the further development of such medications. 
      Hydrogels can be applied directly to the wound site, wherein they function to 
      prevent infection and maintain local moisture concentrations, in addition to 
      serving as a reservoir for the delivery of a range of therapeutic compounds with 
      the potential to expedite wound healing in a synergistic manner. Herein, we 
      synthesized Prussian blue nanoparticles (PBNPs) capable of efficiently scavenging 
      reactive oxygen species (ROS) owing to their ability to mimic the activity of 
      catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD). In the context 
      of in vitro oxidative stress, these PBNPs were able to protect against 
      cytotoxicity, protect mitochondria from oxidative stress-related damage, and 
      restore nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 
      (HO-1) pathway activity. To expand on these results in an in vivo context, we 
      prepared a thermosensitive poly (d,l-lactide)-poly(ethylene 
      glycol)-poly(d,l-lactide) (PDLLA-PEG-PDLLA) hydrogel (PLEL)-based wound dressing 
      in which PBNPs had been homogenously incorporated, and we then used this dressing 
      as a platform for controlled PBNP release. The resultant PBNPs@PLEL wound 
      dressing was able to improve diabetic wound healing, decrease ROS production, 
      promote angiogenesis, and reduce pro-inflammatory interleukin-6 (IL-6) and tumor 
      necrosis factor-alpha (TNF-alpha) levels within diabetic wounds. Overall, our results 
      suggest that this PBNPs@PLEL platform holds great promise as a treatment for 
      diabetic foot ulcers.
FAU - Xu, Zhao
AU  - Xu Z
AD  - Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Liu, Yujing
AU  - Liu Y
AD  - Science and Technology Innovation Center, Guangzhou University of Chinese 
      Medicine, Guangzhou 510405, China.
FAU - Ma, Rui
AU  - Ma R
AD  - Science and Technology Innovation Center, Guangzhou University of Chinese 
      Medicine, Guangzhou 510405, China.
FAU - Chen, Jing
AU  - Chen J
AD  - Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Qiu, Jinmei
AU  - Qiu J
AD  - Science and Technology Innovation Center, Guangzhou University of Chinese 
      Medicine, Guangzhou 510405, China.
FAU - Du, Shuang
AU  - Du S
AD  - Science and Technology Innovation Center, Guangzhou University of Chinese 
      Medicine, Guangzhou 510405, China.
FAU - Li, Chengcheng
AU  - Li C
AD  - Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Wu, Zihan
AU  - Wu Z
AD  - Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Yang, Xiaofan
AU  - Yang X
AD  - Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Chen, Zhenbing
AU  - Chen Z
AUID- ORCID: 0000-0003-2828-866X
AD  - Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430022, China.
FAU - Chen, Tongkai
AU  - Chen T
AUID- ORCID: 0000-0002-4347-0155
AD  - Science and Technology Innovation Center, Guangzhou University of Chinese 
      Medicine, Guangzhou 510405, China.
LA  - eng
PT  - Journal Article
DEP - 20220317
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Ferrocyanides)
RN  - 0 (Hydrogels)
RN  - 0 (Reactive Oxygen Species)
RN  - TLE294X33A (ferric ferrocyanide)
SB  - IM
MH  - *Diabetes Mellitus
MH  - *Diabetic Foot
MH  - Ferrocyanides
MH  - Humans
MH  - Hydrogels/pharmacology
MH  - Mitochondria
MH  - *Nanoparticles
MH  - Reactive Oxygen Species
MH  - Wound Healing
OTO - NOTNLM
OT  - PDLLA-PEG-PDLLA hydrogel
OT  - Prussian blue nanoparticles
OT  - diabetic wound
OT  - mitochondrial dysfunction
OT  - reactive oxygen species
EDAT- 2022/03/18 06:00
MHDA- 2022/04/08 06:00
CRDT- 2022/03/17 17:16
PHST- 2022/03/18 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2022/03/17 17:16 [entrez]
AID - 10.1021/acsami.1c24569 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2022 Mar 30;14(12):14059-14071. doi: 
      10.1021/acsami.1c24569. Epub 2022 Mar 17.