PMID- 35299866
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20220330
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2022
DP  - 2022
TI  - Correlation of Blood Biochemical Markers with Tardive Dyskinesia in Schizophrenic 
      Patients.
PG  - 1767989
LID - 10.1155/2022/1767989 [doi]
LID - 1767989
AB  - OBJECTIVE: Oxidative stress factors and proinflammatory cytokines had been found 
      to be involved in the pathogenesis of patients with tardive dyskinesia (TD). This 
      study assumes that blood biochemical markers would have a link with TD in 
      schizophrenia patients. To explore the correlation between blood biochemical 
      markers and tardive dyskinesia in patients with schizophrenia (SCH). METHODS: 
      From January 2010 to August 2021, the inpatients who met the diagnostic criteria 
      of schizophrenia in the Chinese Classification and Diagnosis Criteria of Mental 
      Disorders (DSM-4) and the American Diagnostic and Statistical Manual of Mental 
      Disorders (DSM-4) were followed up in the psychiatric outpatient department of 
      Jinxia Street Community Health Service Center, Longhu District, Shantou City. The 
      diagnostic criteria of Abnormal Involuntary Movement Scale (AIMS) used in the TD 
      study of Schooler and Kane were used to screen the patients. Patients were 
      divided into the schizophrenia (SCH group) and the schizophrenia with TD groups 
      (TD group). Oxidative stress factors including Superoxide Dismutase1 (SOD1), 
      Glutathione Peroxidase1 (GPX1), Malondialdehyde1 (MDA1), Catalase Activity1 
      (CAT1), and brain-derived neurotrophic factor 1 (BDNF1) and some inflammatory 
      cytokines including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 
      (IL-8), serum tumor necrosis factor (TNF-alpha), prolactin, estrogen, and cortisol 
      were measured in 121 schizophrenic patients with tardive dyskinesia and 118 
      schizophrenic patients. The correlation analysis was conducted on the data. 
      RESULTS: Age and female were immutable risk factors for the development of TD, 
      and there were significant differences in blood biochemical indices GPX1, MDA1, 
      CAT1, and TNF-alpha in schizophrenic patients with and without TD. CONCLUSION: This 
      study supports that oxidative stress and immune disorders are associated with TD 
      patients. Blood biochemical markers GPX1, MDA1, CAT1, and TNF-alpha may play an 
      important role in the pathogenesis of schizophrenia combined with TD patients, 
      and they may be useful in the diagnosis of schizophrenia with tardive dyskinesia.
CI  - Copyright (c) 2022 Qian Wu et al.
FAU - Wu, Qian
AU  - Wu Q
AUID- ORCID: 0000-0002-2049-6707
AD  - School of Medicine, Pingdingshan University, Pingdingshan City 467000, China.
FAU - Yuan, Fengjuan
AU  - Yuan F
AUID- ORCID: 0000-0001-7394-529X
AD  - School of Medicine, Pingdingshan University, Pingdingshan City 467000, China.
FAU - Zhang, Shuo
AU  - Zhang S
AUID- ORCID: 0000-0003-4040-8011
AD  - Department of Endocrine and Metabolic Diseases, Longhu Hospital, The First 
      Affiliated Hospital of Shantou University Medical College, Shantou City 515041, 
      China.
FAU - Liu, Weiting
AU  - Liu W
AUID- ORCID: 0000-0002-4234-9783
AD  - School of Nursing, Anhui University of Chinese Medicine, Hefei City 230012, 
      China.
FAU - Miao, Qing
AU  - Miao Q
AUID- ORCID: 0000-0001-7075-4535
AD  - Department of Physical Education, Henan University of Urban Construction, 
      Pingdingshan City 467000, China.
FAU - Zheng, Xinhua
AU  - Zheng X
AUID- ORCID: 0000-0002-1981-0519
AD  - School of Medicine, Pingdingshan University, Pingdingshan City 467000, China.
FAU - Lu, Suxiang
AU  - Lu S
AUID- ORCID: 0000-0002-5946-1050
AD  - School of Medicine, Pingdingshan University, Pingdingshan City 467000, China.
FAU - Hou, Kaijian
AU  - Hou K
AUID- ORCID: 0000-0003-1733-0068
AD  - Department of Endocrine and Metabolic Diseases, Longhu Hospital, The First 
      Affiliated Hospital of Shantou University Medical College, Shantou City 515041, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220308
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Age Factors
MH  - Biomarkers/*blood
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - Interleukin-6/immunology
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*immunology
MH  - Schizophrenia/blood/*epidemiology
MH  - Sex Factors
MH  - Tardive Dyskinesia/blood/*epidemiology/*immunology
PMC - PMC8923804
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this paper.
EDAT- 2022/03/19 06:00
MHDA- 2022/03/31 06:00
PMCR- 2022/03/08
CRDT- 2022/03/18 05:12
PHST- 2021/11/14 00:00 [received]
PHST- 2022/01/25 00:00 [revised]
PHST- 2022/02/08 00:00 [accepted]
PHST- 2022/03/18 05:12 [entrez]
PHST- 2022/03/19 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2022/03/08 00:00 [pmc-release]
AID - 10.1155/2022/1767989 [doi]
PST - epublish
SO  - Dis Markers. 2022 Mar 8;2022:1767989. doi: 10.1155/2022/1767989. eCollection 
      2022.