PMID- 35301301
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220511
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Mar 17
TI  - Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast 
      cell survival.
PG  - 1418
LID - 10.1038/s41467-022-29032-x [doi]
LID - 1418
AB  - Increased serum levels of immunoglobulin E (IgE) is a risk factor for various 
      diseases, including allergy and anaphylaxis. However, the source and ontogeny of 
      B cells producing IgE under steady state conditions are not well defined. Here, 
      we show plasma cells that develop in the thymus and potently secrete IgE and 
      other immunoglobulins, including IgM, IgA, and IgG. The development of these 
      IgE-secreting plasma cells are induced by IL-4 produced by invariant Natural 
      Killer T cells, independent of CD1d-mediated interaction. Single-cell 
      transcriptomics suggest the developmental landscape of thymic B cells, and the 
      thymus supports development of transitional, mature, and memory B cells in 
      addition to plasma cells. Furthermore, thymic plasma cells produce polyclonal 
      antibodies without somatic hypermutation, indicating they develop via the 
      extra-follicular pathway. Physiologically, thymic-derived IgEs increase the 
      number of mast cells in the gut and skin, which correlates with the severity of 
      anaphylaxis. Collectively, we define the ontogeny of thymic plasma cells and show 
      that steady state thymus-derived IgEs regulate mast cell homeostasis, opening up 
      new avenues for studying the genetic causes of allergic disorders.
CI  - (c) 2022. The Author(s).
FAU - Kwon, Dong-Il
AU  - Kwon DI
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang, 37673, Republic of Korea.
FAU - Park, Eun Seo
AU  - Park ES
AD  - Department of New Biology, DGIST, Daegu, 42988, Republic of Korea.
FAU - Kim, Mingyu
AU  - Kim M
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang, 37673, Republic of Korea.
FAU - Choi, Yoon Ha
AU  - Choi YH
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang, 37673, Republic of Korea.
AD  - Department of New Biology, DGIST, Daegu, 42988, Republic of Korea.
FAU - Lee, Myeong-Seok
AU  - Lee MS
AD  - Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul 
      National University, Seoul, 08826, Republic of Korea.
FAU - Joo, Si-Hyung
AU  - Joo SH
AD  - Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul 
      National University, Seoul, 08826, Republic of Korea.
FAU - Kang, Yeon-Woo
AU  - Kang YW
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang, 37673, Republic of Korea.
FAU - Lee, Minji
AU  - Lee M
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang, 37673, Republic of Korea.
FAU - Jo, Saet-Byeol
AU  - Jo SB
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang, 37673, Republic of Korea.
FAU - Lee, Seung-Woo
AU  - Lee SW
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang, 37673, Republic of Korea.
FAU - Kim, Jong Kyoung
AU  - Kim JK
AUID- ORCID: 0000-0002-0257-0547
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang, 37673, Republic of Korea. blkimjk@postech.ac.kr.
AD  - Department of New Biology, DGIST, Daegu, 42988, Republic of Korea. 
      blkimjk@postech.ac.kr.
FAU - Lee, You Jeong
AU  - Lee YJ
AUID- ORCID: 0000-0002-6786-6955
AD  - Department of Life Sciences, Pohang University of Science and Technology 
      (POSTECH), Pohang, 37673, Republic of Korea. youjeonglee@snu.ac.kr.
AD  - Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul 
      National University, Seoul, 08826, Republic of Korea. youjeonglee@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220317
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Anaphylaxis/metabolism
MH  - Cell Survival
MH  - Homeostasis
MH  - Humans
MH  - *Immunoglobulin E
MH  - Mast Cells
MH  - Plasma Cells
PMC - PMC8930980
COIS- The authors declare no competing interests.
EDAT- 2022/03/19 06:00
MHDA- 2022/04/06 06:00
PMCR- 2022/03/17
CRDT- 2022/03/18 05:40
PHST- 2021/06/17 00:00 [received]
PHST- 2022/02/23 00:00 [accepted]
PHST- 2022/03/18 05:40 [entrez]
PHST- 2022/03/19 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
PHST- 2022/03/17 00:00 [pmc-release]
AID - 10.1038/s41467-022-29032-x [pii]
AID - 29032 [pii]
AID - 10.1038/s41467-022-29032-x [doi]
PST - epublish
SO  - Nat Commun. 2022 Mar 17;13(1):1418. doi: 10.1038/s41467-022-29032-x.