PMID- 35303676
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220505
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 604
DP  - 2022 May 14
TI  - SIRT3 improves bone regeneration and rescues diabetic fracture healing by 
      regulating oxidative stress.
PG  - 109-115
LID - S0006-291X(22)00320-5 [pii]
LID - 10.1016/j.bbrc.2022.03.001 [doi]
AB  - Diabetes mellitus (DM), a chronic metabolic disorder caused by uncontrolled high 
      blood glucose levels due to insufficient insulin secretion or insulin resistance, 
      is one of the most common metabolic diseases globally and is responsible for 
      severe socio-economic burden. DM is associated with impaired fracture healing 
      caused by oxidative stress induced-excessive bone resorption. Sirtuin3 (SIRT3), 
      predominantly located in mitochondria, offers great influence on mitochondrial 
      homeostasis, oxidative stress and immune cell function. However, the exact effect 
      of SIRT3 on fracture healing with DM still remains to be elucidated. The present 
      study demonstrated that SIRT3 expression was diminished in diabetic fracture 
      healing and genetic deletion of SIRT3 increased mitochondrial oxidative stress 
      and delayed diabetic bone healing via exacerbating the impact of DM on cartilage 
      and osteoclast. The Honokiol (HKL) extracted from bark of magnolia trees, is a 
      small molecular weight compound with various pharmaceutical properties by 
      activating SIRT3. Our study proved that the SIRT3 agonist HKL could partially 
      reverse the effect of diabetes on fracture healing, which provides a new 
      promising approach for improving fracture healing in DM.
CI  - Copyright (c) 2022. Published by Elsevier Inc.
FAU - Huang, Xiaowen
AU  - Huang X
AD  - Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical 
      University (Jiangsu Province Hospital), Nanjing, 210029, China.
FAU - Shu, Haoming
AU  - Shu H
AD  - Department of Orthopedics, Changzheng Hospital, Naval Medical University, No.415 
      Fengyang Road, Shanghai, 200003, China.
FAU - Ren, Changzhen
AU  - Ren C
AD  - Department of General Practice, 960th Hospital of PLA, Jinan, 250031, China. 
      Electronic address: renchangzhen90@163.com.
FAU - Zhu, Jian
AU  - Zhu J
AD  - Department of Orthopedics, Changzheng Hospital, Naval Medical University, No.415 
      Fengyang Road, Shanghai, 200003, China. Electronic address: zhuspine@smmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220302
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - EC 3.5.1.- (SIRT3 protein, human)
RN  - EC 3.5.1.- (Sirtuin 3)
SB  - IM
MH  - Bone Regeneration
MH  - *Diabetes Mellitus
MH  - Fracture Healing
MH  - Humans
MH  - Oxidative Stress
MH  - *Sirtuin 3/metabolism
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Honokiol
OT  - Osteogenesis
OT  - Oxidative stress
OT  - SIRT3
COIS- Declaration of competing interest All authors declare that they have no known 
      conflict of interests or personal relationships that could have appeared to 
      influence the work reported in the present study.
EDAT- 2022/03/19 06:00
MHDA- 2022/04/12 06:00
CRDT- 2022/03/18 20:13
PHST- 2022/01/20 00:00 [received]
PHST- 2022/02/24 00:00 [revised]
PHST- 2022/03/01 00:00 [accepted]
PHST- 2022/03/19 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2022/03/18 20:13 [entrez]
AID - S0006-291X(22)00320-5 [pii]
AID - 10.1016/j.bbrc.2022.03.001 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2022 May 14;604:109-115. doi: 
      10.1016/j.bbrc.2022.03.001. Epub 2022 Mar 2.