PMID- 35305398
OWN - NLM
STAT- MEDLINE
DCOM- 20220414
LR  - 20230402
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Print)
IS  - 0143-4004 (Linking)
VI  - 121
DP  - 2022 Apr
TI  - Maternal, placental, and fetal distribution of titanium after repeated titanium 
      dioxide nanoparticle inhalation through pregnancy.
PG  - 99-108
LID - S0143-4004(22)00076-5 [pii]
LID - 10.1016/j.placenta.2022.03.008 [doi]
AB  - Epidemiological studies have associated ambient engineered nanomaterials or 
      ultrafine particulate matter (PM(0.1)), collectively referred to as nanoparticles 
      (NPs), with adverse pregnancy outcomes including miscarriage, preterm labor, and 
      fetal growth restriction. Evidence from non-pregnant models demonstrate that NPs 
      can cross the lung air-blood barrier and circulate systemically. Therefore, 
      inhalation of NPs during pregnancy leading to fetoplacental exposure has garnered 
      attention. The purpose of this study was to evaluate the distribution of inhaled 
      titanium dioxide nanoparticles (nano-TiO(2)) from the maternal lung to maternal 
      and fetal systemic tissues. Pregnant Sprague Dawley rats were administered 
      whole-body exposure to filtered air or of nano-TiO(2) aerosols 
      (9.96 +/- 0.06 mg/m(3)) between gestational day (GD) 4 and 19. On GD 20 maternal, 
      placental, and fetal tissues were harvested then digested for ICP-MS analysis to 
      measure concentrations of titanium (Ti). TEM was used to visualize particle 
      internalization by the placental syncytium. The results demonstrate the 
      extrapulmonary distribution of Ti to various maternal organs during pregnancy. 
      Our study found Ti accumulation in the decidua/junctional and labyrinth zones of 
      placentas embedded in all sections of uterine horns. Further, NPs deposited in 
      the placenta, identified by TEM, were found intracellularly within nuclear, 
      endoplasmic reticulum, and vesicle organelles. This study identified the systemic 
      distribution and placental accumulation of Ti after nano-TiO(2) aerosol 
      inhalation in a pregnancy model. These findings arouse concerns for poor air 
      quality for pregnant women and possible contributions to adverse pregnancy 
      outcomes.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - D'Errico, J N
AU  - D'Errico JN
AD  - Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, 
      Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.
FAU - Doherty, C
AU  - Doherty C
AD  - Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Rd, 
      Piscataway, NJ, 08854, USA.
FAU - Reyes George, J J
AU  - Reyes George JJ
AD  - Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, 
      Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.
FAU - Buckley, B
AU  - Buckley B
AD  - Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, 
      Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ, 08854, USA; 
      Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Rd, 
      Piscataway, NJ, 08854, USA.
FAU - Stapleton, P A
AU  - Stapleton PA
AD  - Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, 
      Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ, 08854, USA; 
      Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Rd, 
      Piscataway, NJ, 08854, USA. Electronic address: stapleton@eohsi.rutgers.edu.
LA  - eng
GR  - T32 ES007148/ES/NIEHS NIH HHS/United States
GR  - R25 ES020721/ES/NIEHS NIH HHS/United States
GR  - P30 ES005022/ES/NIEHS NIH HHS/United States
GR  - R00 ES024783/ES/NIEHS NIH HHS/United States
GR  - R01 ES031285/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20220312
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - *Abortion, Spontaneous
MH  - Animals
MH  - Female
MH  - Fetus
MH  - Maternal Exposure/adverse effects
MH  - *Nanoparticles/adverse effects
MH  - Placenta
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Titanium/adverse effects
PMC - PMC9010360
MID - NIHMS1790122
OTO - NOTNLM
OT  - Fetal sex
OT  - ICP-MS
OT  - Intrauterine position
OT  - Placenta
OT  - TEM
OT  - Titanium dioxide nanoparticles
COIS- Declaration of conflicting interest: None.
EDAT- 2022/03/20 06:00
MHDA- 2022/04/15 06:00
PMCR- 2023/04/01
CRDT- 2022/03/19 20:07
PHST- 2021/11/30 00:00 [received]
PHST- 2022/02/07 00:00 [revised]
PHST- 2022/03/03 00:00 [accepted]
PHST- 2022/03/20 06:00 [pubmed]
PHST- 2022/04/15 06:00 [medline]
PHST- 2022/03/19 20:07 [entrez]
PHST- 2023/04/01 00:00 [pmc-release]
AID - S0143-4004(22)00076-5 [pii]
AID - 10.1016/j.placenta.2022.03.008 [doi]
PST - ppublish
SO  - Placenta. 2022 Apr;121:99-108. doi: 10.1016/j.placenta.2022.03.008. Epub 2022 Mar 
      12.