PMID- 35306088 OWN - NLM STAT- MEDLINE DCOM- 20220412 LR - 20240216 IS - 1873-6424 (Electronic) IS - 0269-7491 (Print) IS - 0269-7491 (Linking) VI - 303 DP - 2022 Jun 15 TI - Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN). PG - 119164 LID - S0269-7491(22)00378-5 [pii] LID - 10.1016/j.envpol.2022.119164 [doi] AB - Adipokines, cytokines secreted by adipose tissue, may contribute to obesity-related metabolic disease. The role of environmental phenols and parabens in racial difference in metabolic disease burden has been suggested, but there is limited evidence. We examined the cross-sectional associations of urinary phenols and parabens with adipokines and effect modification by race. Urinary concentrations of 6 phenols (bisphenol-A, bisphenol-F, 2,4-diclorophenol, 2,5-diclorophenol, triclosan, benzophenone-3) and 4 parabens (methyl-paraben, ethyl-paraben, propyl-paraben, butyl-paraben) were measured in 2002-2003 among 1200 women (mean age = 52.6) enrolled in the Study of Women's Health Across the Nation Multi-Pollutant Study. Serum adipokines included adiponectin, high molecular weight (HMW)-adiponectin, leptin, soluble leptin receptor (sOB-R). Linear regression models were used to estimate the adjusted percentage change in adipokines per inter-quantile range (IQR) increase in standardized and log-transformed levels of individual urinary phenols and parabens. Bayesian kernel machine regression (BKMR) was used to evaluate the joint effect of urinary phenols and parabens as mixtures. Participants included white (52.5%), black (19.3%), and Asian (28.1%) women. Urinary 2,4-dichlorophenol was associated with 6.02% (95% CI: 1.20%, 10.83%) higher HMW-adiponectin and urinary bisphenol-F was associated with 2.60% (0.48%, 4.71%) higher sOB-R. Urinary methyl-paraben was associated with lower leptin in all women but this association differed by race: 8.58% (-13.99%, -3.18%) lower leptin in white women but 11.68% (3.52%, 19.84%) higher leptin in black women (P interaction = 0.001). No significant associations were observed in Asian women. Additionally, we observed a significant positive overall effect of urinary phenols and parabens mixtures in relation to leptin levels in black, but not in white or Asian women. Urinary bisphenol-F, 2,4-dichlorophenol and methyl-paraben may be associated with favorable profiles of adipokines, but methyl-paraben, widely used in hair and personal care products, was associated with unfavorable leptin levels in black women. Future studies are needed to confirm this racial difference. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Lee, Seulbi AU - Lee S AD - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States; Department of Big Data Strategy, National Health Insurance Service, Wonju, Republic of Korea. FAU - Karvonen-Gutierrez, Carrie AU - Karvonen-Gutierrez C AD - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States. FAU - Mukherjee, Bhramar AU - Mukherjee B AD - Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, United States. FAU - Herman, William H AU - Herman WH AD - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States. FAU - Park, Sung Kyun AU - Park SK AD - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States. Electronic address: sungkyun@umich.edu. LA - eng GR - T42 OH008455/OH/NIOSH CDC HHS/United States GR - R01 AG062622/AG/NIA NIH HHS/United States GR - P30 DK092926/DK/NIDDK NIH HHS/United States GR - U01 AG012554/AG/NIA NIH HHS/United States GR - P30 AG024824/AG/NIA NIH HHS/United States GR - UL1 RR024131/RR/NCRR NIH HHS/United States GR - T42OH008455/ACL/ACL HHS/United States GR - P30 ES017885/ES/NIEHS NIH HHS/United States GR - U01 AG012535/AG/NIA NIH HHS/United States GR - U01 AG012553/AG/NIA NIH HHS/United States GR - U01 NR004061/NR/NINR NIH HHS/United States GR - U01 AG012539/AG/NIA NIH HHS/United States GR - R01 ES026578/ES/NIEHS NIH HHS/United States GR - U01 AG012546/AG/NIA NIH HHS/United States GR - U19 AG063720/AG/NIA NIH HHS/United States GR - U01 AG012495/AG/NIA NIH HHS/United States GR - P30 DK020572/DK/NIDDK NIH HHS/United States GR - U01 AG012505/AG/NIA NIH HHS/United States GR - U01 AG012531/AG/NIA NIH HHS/United States GR - R01 ES026964/ES/NIEHS NIH HHS/United States GR - U01 AG017719/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20220316 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Adipokines) RN - 0 (Adiponectin) RN - 0 (Leptin) RN - 0 (Parabens) RN - 0 (Phenols) SB - IM MH - Adipokines MH - Adiponectin MH - Bayes Theorem MH - Cross-Sectional Studies MH - Female MH - Humans MH - *Leptin MH - Middle Aged MH - *Parabens MH - Phenols/urine MH - Women's Health PMC - PMC9883839 MID - NIHMS1865848 OTO - NOTNLM OT - Adipokines OT - Adiponectin OT - Environmental disparities OT - Leptin OT - Midlife women OT - Parabens OT - Phenols COIS- Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/03/21 06:00 MHDA- 2022/04/13 06:00 PMCR- 2023/06/15 CRDT- 2022/03/20 20:27 PHST- 2021/11/12 00:00 [received] PHST- 2022/02/22 00:00 [revised] PHST- 2022/03/14 00:00 [accepted] PHST- 2022/03/21 06:00 [pubmed] PHST- 2022/04/13 06:00 [medline] PHST- 2022/03/20 20:27 [entrez] PHST- 2023/06/15 00:00 [pmc-release] AID - S0269-7491(22)00378-5 [pii] AID - 10.1016/j.envpol.2022.119164 [doi] PST - ppublish SO - Environ Pollut. 2022 Jun 15;303:119164. doi: 10.1016/j.envpol.2022.119164. Epub 2022 Mar 16.