PMID- 35306370
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20220413
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1670
DP  - 2022 May 10
TI  - Enantioseparation in capillary eletrochromatography by covalent organic framework 
      coating prepared in situ.
PG  - 462943
LID - S0021-9673(22)00141-8 [pii]
LID - 10.1016/j.chroma.2022.462943 [doi]
AB  - Chiral covalent organic frameworks (CCOFs) have recently exhibited particularly 
      promising potential as effective chiral stationary phases (CSPs) for open tubular 
      capillary electrochromatography (OT-CEC) enantioseparation. However, it remains 
      difficult to synthesis of CCOFs and preparation of CCOFs coated capillary under 
      mild reaction conditions. In this work, we designed and fabricated a CCOF 
      (CB-DA-COF) with high chemical stability and high specific surface area at room 
      temperature. Then, through one-step in situ growth method, the chiral CB-DA-COF 
      coated capillary was fabricated at room temperature for the first time. This 
      method requires neither pre-modification to the capillary by organic molecular 
      building units nor harsh reaction conditions, and the preparation time of the 
      CCOF coating was significantly shortened (within 2 h). This chiral CB-DA-COF 
      coated capillary showed excellent enantioseparation ability and stability. Under 
      optimal conditions, rapid enantioseparation (within 5 min) could be achieved for 
      six enantiomers including terbutaline, propranolol, phenylephrine, verapamil, 
      norepinephrine and isoprenaline. And, no significant change was observed in 
      enantioseparation efficiency after over 200 runs. The relative standard 
      deviations (RSDs) of the analyte's migration time for intra-day, inter-day and 
      column-to-column were within the range of 0.8-3.5% (n = 5), 1.5-4.7% (n = 3) and 
      4.3-8.3% (n = 3), respectively. In addition, the enantioseparation mechanism was 
      studied, which indicated that binding energy between of enantiomers and chiral 
      site were the main factors for enantioseparation.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Wang, Guoxiu
AU  - Wang G
AD  - Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, 
      Lanzhou University, South Road of Tianshui, 222, Departm, Lanzhou 730000, China.
FAU - Chen, Yonglei
AU  - Chen Y
AD  - Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, 
      Lanzhou University, South Road of Tianshui, 222, Departm, Lanzhou 730000, China. 
      Electronic address: chyl@lzu.edu.cn.
FAU - Lv, Wenjuan
AU  - Lv W
AD  - Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, 
      Lanzhou University, South Road of Tianshui, 222, Departm, Lanzhou 730000, China. 
      Electronic address: lvwenj@lzu.edu.cn.
FAU - Pan, Congjie
AU  - Pan C
AD  - Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, 
      Lanzhou University, South Road of Tianshui, 222, Departm, Lanzhou 730000, China.
FAU - Zhang, Huige
AU  - Zhang H
AD  - Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, 
      Lanzhou University, South Road of Tianshui, 222, Departm, Lanzhou 730000, China.
FAU - Chen, Hongli
AU  - Chen H
AD  - Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, 
      Lanzhou University, South Road of Tianshui, 222, Departm, Lanzhou 730000, China.
FAU - Chen, Xingguo
AU  - Chen X
AD  - Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, 
      Lanzhou University, South Road of Tianshui, 222, Departm, Lanzhou 730000, China; 
      College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 
      730000, China. Electronic address: chenxg@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220313
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Metal-Organic Frameworks)
RN  - N8ONU3L3PG (Terbutaline)
SB  - IM
MH  - *Capillary Electrochromatography/methods
MH  - *Metal-Organic Frameworks/chemistry
MH  - Stereoisomerism
MH  - Terbutaline
OTO - NOTNLM
OT  - Chiral covalent organic frameworks
OT  - In situ growth method *enantioseparation
OT  - Open tubular capillary electrochromatography
COIS- Declaration of Competing Interest The authors declare that they have no conflict 
      of interest or personal relationships that could have appeared to influence the 
      work reported here.
EDAT- 2022/03/21 06:00
MHDA- 2022/04/14 06:00
CRDT- 2022/03/20 20:31
PHST- 2021/12/07 00:00 [received]
PHST- 2022/02/25 00:00 [revised]
PHST- 2022/03/05 00:00 [accepted]
PHST- 2022/03/21 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/03/20 20:31 [entrez]
AID - S0021-9673(22)00141-8 [pii]
AID - 10.1016/j.chroma.2022.462943 [doi]
PST - ppublish
SO  - J Chromatogr A. 2022 May 10;1670:462943. doi: 10.1016/j.chroma.2022.462943. Epub 
      2022 Mar 13.