PMID- 35306549
OWN - NLM
STAT- MEDLINE
DCOM- 20220427
LR  - 20220531
IS  - 1842-1121 (Electronic)
IS  - 1841-8724 (Linking)
VI  - 31
IP  - 1
DP  - 2022 Mar 19
TI  - Romanian Guidelines for the Diagnosis and Treatment of GERD-induced Respiratory 
      Manifestations.
PG  - 119-142
LID - 10.15403/jgld-4196 [doi]
AB  - BACKGROUND AND AIMS: Gastroesophageal reflux disease (GERD) is a common condition 
      present in daily practice with a wide range of clinical phenotypes. In this line, 
      respiratory conditions may be associated with GERD. The Romanian Societies of 
      Gastroenterology and Neurogastroenterology, in association with the Romanian 
      Society of Pneumology, aimed to create a guideline regarding the epidemiology, 
      diagnosis and treatment of respiratory conditions associated with GERD. METHODS: 
      Delphi methodology was used and eleven common working groups of experts were 
      created. The experts reviewed the literature according to GRADE criteria and 
      formulated 34 statements and recommendations. Consensus (>80% agreement) was 
      reached for some of the statements after all participants voted. RESULTS: All the 
      statements and the literature review are presented in the paper, together with 
      their correspondent grade of evidence and the voting results. Based on >80% 
      voting agreement, a number of 22 recommendations were postulated regarding the 
      diagnosis and treatment of GERD-induced respiratory symptoms. The experts 
      considered that GERD may cause bronchial asthma and chronic cough in an important 
      number of patients through micro-aspiration and vagal-mediated tracheobronchial 
      reflex. GERD should be suspected in patients with asthma with suboptimal 
      controlled or after exclusion of other causes, also in nocturnal refractory cough 
      which needs gastroenterological investigations to confirm the diagnosis. 
      Therapeutic test with double dose proton pump inhibitors (PPI) for 3 months is 
      also useful. GERD induced respiratory conditions are difficult to treat; 
      however,proton pump inhibitors and laparoscopic Nissen fundoplication are 
      endorsed for therapy. CONCLUSIONS: This guideline could be useful for the 
      multidisciplinary management of GERD with respiratory symptoms in current 
      practice.
FAU - Drug, Vasile Liviu
AU  - Drug VL
AD  - Grigore T. Popa University of Medicine and Pharmacy, Iasi; Institute of 
      Gastroenterology and Hepatology, Saint Spiridon Hospital, Iasi, Romania. . 
      vasidrug@email.com.
FAU - Antoniu, Sabina
AU  - Antoniu S
AD  - Grigore T. Popa University of Medicine and Pharmacy, Iasi; Pneumology Hospital, 
      Iasi, Romania. sabina.antoniu@outlook.com.
FAU - Oana, Barboi Bogdana
AU  - Oana BB
AD  - Grigore T. Popa University of Medicine and Pharmacy, Iasi; Institute of 
      Gastroenterology and Hepatology, Saint Spiridon Hospital, Iasi, Romania. 
      oany_leo@yahoo.com.
FAU - Arghir, Oana Cristina
AU  - Arghir OC
AD  - Faculty of Medicine, Ovidius University, Constanta; Pneumology Hospital, 
      Constanta, Romania. arghir_oana@yahoo.com.
FAU - Bancila, Ion
AU  - Bancila I
AD  - Center of Gastroenterology and Hepatology Fundeni Clinical Institute, Bucharest, 
      Romania. ibancila@yahoo.com.
FAU - Bataga, Simona
AU  - Bataga S
AD  - George E. Palade University of Medicine, Pharmacy, Sciences and Technology, 
      Targu-Mures; County Emergency Clinical Hospital, Targu-Mures, Romania. 
      simonabataga@yahoo.com.
FAU - Brisc, Ciprian
AU  - Brisc C
AD  - University of Oradea, Faculty of Medicine and Pharmacy, Romania; Clinical 
      Hospital, Oradea, Romania. brisciprian@gmail.com.
FAU - Cijevschi-Prelipcean, Cristina
AU  - Cijevschi-Prelipcean C
AD  - Grigore T. Popa University of Medicine and Pharmacy, Iasi; Institute of 
      Gastroenterology and Hepatology, Saint Spiridon Hospital, Iasi, Romania. 
      cristinacijevschi@yahoo.com.
FAU - Ciocirlan, Mihai
AU  - Ciocirlan M
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;. 
      ciocirlan@gmail.com.
FAU - Ciortescu, Irina
AU  - Ciortescu I
AD  - Grigore T. Popa University of Medicine and Pharmacy, Iasi; Institute of 
      Gastroenterology and Hepatology, Saint Spiridon Hospital, Iasi, Romania. 
      irinaciortescu@yahoo.com.
FAU - David, Liliana
AU  - David L
AD  - University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania; 2nd 
      Department of Internal Medicine, Cluj County Emergency Clinical Hospital, 
      Cluj-Napoca, Romania. lilidavid2007@yahoo.com.
FAU - Deleanu, Oana Claudia
AU  - Deleanu OC
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Marius 
      Nasta Institute of Pneumology, Bucharest, Romania. oanadeleanu@yahoo.com.
FAU - Diculescu, Mircea
AU  - Diculescu M
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Center of 
      Gastroenterology and Hepatology Fundeni Clinical Institute, Bucharest, Romania. 
      mmdiculescu@yahoo.com.
FAU - Dimitriu, Anca
AU  - Dimitriu A
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Center of 
      Gastroenterology and Hepatology Fundeni Clinical Institute, Bucharest, Romania. 
      borcaanca@yahoo.com.
FAU - Dobru, Daniela
AU  - Dobru D
AD  - George E. Palade University of Medicine, Pharmacy, Sciences and Technology, 
      Targu-Mures, Romania; County Emergency Clinical Hospital, Targu-Mures, Romania. 
      danidobru@gmail.com.
FAU - Dumitru, Eugen
AU  - Dumitru E
AD  - Faculty of Medicine, Ovidius University, Constanta, Romania; Saint Apostol Andrei 
      Hospital, Constanta, Romania. eugen.dumitru@yahoo.com.
FAU - Gheonea, Dan Ionut
AU  - Gheonea DI
AD  - University of Medicine and Pharmacy Craiova, Romania; County Emergency Hospital, 
      Craiova, Romania. digheonea@gmail.com.
FAU - Gheorghe, Cristian
AU  - Gheorghe C
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Center of 
      Gastroenterology and Hepatology Fundeni Clinical Institute, Bucharest, Romania. 
      drcgheorghe@gmail.com.
FAU - Goldis, Adrian
AU  - Goldis A
AD  - Department of Gastroenterology and Hepatology, Victor Babes University of 
      Medicine and Pharmacy, Timisoara. goldisadi@yahoo.com.
FAU - Jinga, Mariana
AU  - Jinga M
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Dr. Carol 
      Davila Central University Emergency Military Hospital, Bucharest, Romania. 
      mariana_jinga@yahoo.com.
FAU - Man, Milena
AU  - Man M
AD  - Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Leon 
      Daniello Pneumology Hospital, Cluj-Napoca, Romania. manmilena50@yahoo.com.
FAU - Mateescu, Bogdan
AU  - Mateescu B
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Department 
      of Gastroenterology, Colentina Clinical Hospital, Bucharest, Romania. 
      bogmateescu@gmail.com.
FAU - Manuc, Mircea
AU  - Manuc M
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Center of 
      Gastroenterology and Hepatology Fundeni Clinical Institute, Bucharest, Romania. 
      m_manuc@yahoo.com.
FAU - Mihai, Catalina
AU  - Mihai C
AD  - Grigore T. Popa University of Medicine and Pharmacy, Iasi; Institute of 
      Gastroenterology and Hepatology, Saint Spiridon Hospital, Iasi, Romania. 
      catalinamihai@yahoo.com.
FAU - Mihaltan, Florin
AU  - Mihaltan F
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Marius 
      Nasta Institute of Pneumology, Bucharest, Romania. mihaltan@starnets.ro.
FAU - Mihaescu, Traian
AU  - Mihaescu T
AD  - Grigore T. Popa University of Medicine and Pharmacy, Iasi; 2) Institute of 
      Gastroenterology and Hepatology, Saint Spiridon Hospital, Iasi; 3) Pneumology 
      Hospital, Iasi;. traian@mihaescu.eu.
FAU - Nedelcu, Laurentiu
AU  - Nedelcu L
AD  - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2nd 
      Department of Gastroenterology, Emergency University Hospital, Bucharest, 
      Romania. laurnedelcu@yahoo.com.
FAU - Negreanu, Lucian
AU  - Negreanu L
AD  - University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania;2nd 
      Department of Gastroenterology, Emergency University Hospital, Bucharest, 
      Romania. negreanu_99@yahoo.com.
FAU - Pop, Carmen Monica
AU  - Pop CM
AD  - Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Leon 
      Daniello Pneumology Hospital, Cluj-Napoca, Romania. cpop@umfcluj.ro.
FAU - Rajnoveanu, Ruxandra
AU  - Rajnoveanu R
AD  - Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Leon 
      Daniello Pneumology Hospital, Cluj-Napoca, Romania. 
      ruandra.rajnoveanu@umfcluj.ro.
FAU - Saftoiu, Adrian
AU  - Saftoiu A
AD  - University of Medicine and Pharmacy Craiova, Romania. adriansaftoiu@gmail.com.
FAU - Seicean, Andrada
AU  - Seicean A
AD  - Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Prof. 
      Dr. Octavian Fodor Institute of Gastroenterology and Hepatology, Cluj-Napoca, 
      Romania. andradaseicean@gmail.com.
FAU - Sporea, Ioan
AU  - Sporea I
AD  - Department of Gastroenterology and Hepatology, Victor Babes University of 
      Medicine and Pharmacy, Timisoara. isporea@umft.ro.
FAU - Stanciu, Carol
AU  - Stanciu C
AD  - University of Medicine and Pharmacy "Grigore T. Popa, Iasi, Romania; Institute of 
      Gastroenterology and Hepatology, "Saint Spiridon" Hospital, Iasi, Romania. 
      stanciucarol@yahoo.com.
FAU - Surdea-Blaga, Teodora
AU  - Surdea-Blaga T
AD  - University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania; 2nd 
      Department of Internal Medicine, Cluj County Emergency Clinical Hospital, 
      Cluj-Napoca, Romania. dora_blaga@yahoo.com.
FAU - Tantau, Marcel
AU  - Tantau M
AD  - Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Prof. 
      Dr. Octavian Fodor Institute of Gastroenterology and Hepatology, Cluj-Napoca, 
      Romania. matantau@gmail.com.
FAU - Todea, Doina
AU  - Todea D
AD  - Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Leon 
      Daniello Pneumology Hospital, Cluj-Napoca, Romania. dtodea@umfcluj.ro.
FAU - Trifan, Anca Victorita
AU  - Trifan AV
AD  - Grigore T. Popa University of Medicine and Pharmacy, Iasi; Institute of 
      Gastroenterology and Hepatology, Saint Spiridon Hospital, Iasi, Romania. 
      ancatrifan@yahoo.com.
FAU - Ulmeanu, Ruxandra
AU  - Ulmeanu R
AD  - University of Oradea, Faculty of Medicine and Pharmacy, Romania; Marius Nasta 
      Institute of Pneumology, Bucharest, Romania. r_ulmeanu@yahoo.com.
FAU - Iov, Diana Elena
AU  - Iov DE
AD  - Institute of Gastroenterology and Hepatology, Saint Spiridon Hospital, Iasi, 
      Romania. iovdiana95@gmail.com.
FAU - Dumitrascu, Dan Lucian
AU  - Dumitrascu DL
AD  - University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania; 2nd 
      Department of Internal Medicine, Cluj County Emergency Clinical Hospital, 
      Cluj-Napoca, Romania. dan_dumitrascu@yahoo.de.
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20220319
PL  - Romania
TA  - J Gastrointestin Liver Dis
JT  - Journal of gastrointestinal and liver diseases : JGLD
JID - 101272825
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Cough/complications/drug therapy
MH  - *Gastroenterology
MH  - *Gastroesophageal Reflux/complications/diagnosis/therapy
MH  - Humans
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Romania/epidemiology
EDAT- 2022/03/21 06:00
MHDA- 2022/04/28 06:00
CRDT- 2022/03/20 20:35
PHST- 2022/01/08 00:00 [received]
PHST- 2022/03/01 00:00 [accepted]
PHST- 2022/03/20 20:35 [entrez]
PHST- 2022/03/21 06:00 [pubmed]
PHST- 2022/04/28 06:00 [medline]
AID - 10.15403/jgld-4196 [doi]
PST - epublish
SO  - J Gastrointestin Liver Dis. 2022 Mar 19;31(1):119-142. doi: 10.15403/jgld-4196.