PMID- 35308493
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220322
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 9
DP  - 2022
TI  - Biological Features of the Outcome-Based Intrinsic Capacity Composite Scores From 
      a Population-Based Cohort Study: Pas de Deux of Biological and Functional Aging.
PG  - 851882
LID - 10.3389/fmed.2022.851882 [doi]
LID - 851882
AB  - INTRODUCTION: This study aims to develop and validate an integrative intrinsic 
      capacity (IC) scoring system, to investigate its associations with a wide 
      spectrum of biomarkers and to explore the predictive value of the integrative IC 
      score on 4-year mortality among community dwelling people aged 50 years and 
      older. METHODS: We included 839 adults aged >/=50 years from the Social Environment 
      and Biomarkers of Aging Study (SEBAS) and randomly divided them into derivation 
      and validation cohorts to develop the IC scoring system. The multivariate 
      logistic regression model was used to weight each subdomain (locomotion, sensory, 
      vitality, psychological, and cognition) of IC according to its association with 
      impairments in instrumental activities of daily living (IADL) and to construct 
      the integrative IC score. Age-related biomarkers and genetic markers were 
      compared between IC groups by ordinal logistic regression. A Cox proportional 
      hazard model was used to examine the association between IC and mortality, and 
      subgroup analysis was used to assess the robustness of the results among 
      participants aged 60 years and older. RESULTS: A 12-score IC scoring system 
      (AUROC = 0.83; Hosmer-Lemeshow goodness-of-fit test p = 0.17) was developed, and 
      higher scores indicated better intrinsic capacity. High interleukin (IL)-6, high 
      E-selectin, low serum albumin and low folate were significantly associated with 
      low IC in the whole sample. However, high IL-6, low serum albumin, low folate, 
      high allostatic load, and APOE epsilon4 genotype were significantly associated with low 
      IC in those aged 60 years old and older. Compared to the high IC group, the low 
      IC group was significantly associated with all-cause mortality (HR: 2.50, 95% CI: 
      1.22-5.11, p = 0.01 for all participants; HR 2.19, 95% CI 1.03-4.64, p = 0.04 for 
      participants aged 60 years and older). CONCLUSIONS: The conceptually proposed IC 
      can be easily transformed into a scoring system considering different weights of 
      individual subdomains, which not only predicts mortality but also suggests 
      different pathophysiologies across the life course of aging (inflammation, 
      nutrition, stress, and ApoE4 genotype). An intervention study is needed using the 
      composite IC score to promote healthy aging and determine the underlying 
      pathophysiology.
CI  - Copyright (c) 2022 Meng, Huang, Peng, Chen and Hsiao.
FAU - Meng, Lin-Chieh
AU  - Meng LC
AD  - Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Huang, Shih-Tsung
AU  - Huang ST
AD  - Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Peng, Li-Ning
AU  - Peng LN
AD  - Aging and Health Research Center, National Yang Ming Chiao Tung University 
      Yangming Campus, Taipei, Taiwan.
AD  - Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, 
      Taiwan.
FAU - Chen, Liang-Kung
AU  - Chen LK
AD  - Aging and Health Research Center, National Yang Ming Chiao Tung University 
      Yangming Campus, Taipei, Taiwan.
AD  - Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, 
      Taiwan.
AD  - Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.
FAU - Hsiao, Fei-Yuan
AU  - Hsiao FY
AD  - Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
AD  - School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 
      Taiwan.
AD  - Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20220304
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8931213
OTO - NOTNLM
OT  - biomarkers
OT  - genetic markers
OT  - healthy aging
OT  - intrinsic capacity
OT  - mortality
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The handling editor declared a past co-authorship with 
      several of the authors L-KC and L-NP.
EDAT- 2022/03/22 06:00
MHDA- 2022/03/22 06:01
PMCR- 2022/03/04
CRDT- 2022/03/21 08:40
PHST- 2022/01/10 00:00 [received]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2022/03/21 08:40 [entrez]
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/03/22 06:01 [medline]
PHST- 2022/03/04 00:00 [pmc-release]
AID - 10.3389/fmed.2022.851882 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Mar 4;9:851882. doi: 10.3389/fmed.2022.851882. 
      eCollection 2022.