PMID- 35309178
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220408
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2022
DP  - 2022
TI  - Targeting COPD with PLGA-Based Nanoparticles: Current Status and Prospects.
PG  - 5058121
LID - 10.1155/2022/5058121 [doi]
LID - 5058121
AB  - Chronic obstructive pulmonary disease (COPD) is pulmonary emphysema characterized 
      by blockage in the airflow resulting in the long-term breathing problem, hence a 
      major cause of mortality worldwide. Excessive generation of free radicals and the 
      development of chronic inflammation are the major two episodes underlying the 
      pathogenesis of COPD. Currently used drugs targeting these episodes including 
      anti-inflammatory, antioxidants, and corticosteroids are unsafe, require high 
      doses, and pose serious side effects. Nanomaterial-conjugated drugs have shown 
      promising therapeutic potential against different respiratory diseases as they 
      are required in small quantities which lower overall treatment costs and can be 
      effectively targeted to diseased tissue microenvironment hence having minimal 
      side effects. Poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) are safe as 
      their breakdown products are easily metabolized in the body. Drugs loaded on the 
      PLGA NPs have been shown to be promising agents as anticancer, antimicrobial, 
      antioxidants, and anti-inflammatory. Surface modification of PLGA NPs can further 
      improve their mechanical properties, drug loading potential, and pharmacological 
      activities. In the present review, we have presented a brief insight into the 
      pathophysiological mechanism underlying COPD and highlighted the role, potential, 
      and current status of PLGA NPs loaded with drugs in the therapy of COPD.
CI  - Copyright (c) 2022 Juhi Saxena et al.
FAU - Saxena, Juhi
AU  - Saxena J
AUID- ORCID: 0000-0001-7555-4292
AD  - Department of Biotechnology, University Institute of Biotechnology, Chandigarh 
      University, Mohali, Punjab 140413, India.
AD  - Faculty of Applied Sciences and Biotechnology, Shoolini University of 
      Biotechnology and Management Sciences, Bajhol, Solan, Himachal Pradesh 173229, 
      India.
FAU - Bisen, Monish
AU  - Bisen M
AUID- ORCID: 0000-0001-5890-5265
AD  - Faculty of Applied Sciences and Biotechnology, Shoolini University of 
      Biotechnology and Management Sciences, Bajhol, Solan, Himachal Pradesh 173229, 
      India.
FAU - Misra, Aditya
AU  - Misra A
AUID- ORCID: 0000-0003-1475-4148
AD  - Faculty of Applied Sciences and Biotechnology, Shoolini University of 
      Biotechnology and Management Sciences, Bajhol, Solan, Himachal Pradesh 173229, 
      India.
FAU - Srivastava, Vijay Kumar
AU  - Srivastava VK
AUID- ORCID: 0000-0002-3902-9391
AD  - Amity Institute of Biotechnology, Amity University Rajasthan, Amity Education 
      Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
FAU - Kaushik, Sanket
AU  - Kaushik S
AUID- ORCID: 0000-0003-0386-881X
AD  - Amity Institute of Biotechnology, Amity University Rajasthan, Amity Education 
      Valley, Kant Kalwar, NH-11C, Jaipur-Delhi Highway, Jaipur, India.
FAU - Siddiqui, Arif Jamal
AU  - Siddiqui AJ
AUID- ORCID: 0000-0002-6236-0920
AD  - Department of Biology, College of Science, University of Ha'il, Ha'il, P.O. Box 
      2440, Saudi Arabia.
FAU - Mishra, Neetu
AU  - Mishra N
AUID- ORCID: 0000-0002-0526-2056
AD  - Symbiosis School of Biological Sciences, Symbiosis International (Deemed 
      University), Pune, Maharashtra 412115, India.
FAU - Singh, Abhijeet
AU  - Singh A
AUID- ORCID: 0000-0001-5274-6080
AD  - Department of Biosciences, Manipal University Jaipur, Rajasthan 303007, India.
FAU - Jyoti, Anupam
AU  - Jyoti A
AUID- ORCID: 0000-0002-4135-7466
AD  - Department of Biotechnology, University Institute of Biotechnology, Chandigarh 
      University, Mohali, Punjab 140413, India.
AD  - Faculty of Applied Sciences and Biotechnology, Shoolini University of 
      Biotechnology and Management Sciences, Bajhol, Solan, Himachal Pradesh 173229, 
      India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220311
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Antioxidants)
RN  - 0 (Drug Carriers)
RN  - 0 (Glycols)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Antioxidants/therapeutic use
MH  - Drug Carriers
MH  - Glycols
MH  - Humans
MH  - Lactic Acid
MH  - *Nanoparticles/therapeutic use
MH  - Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - *Pulmonary Disease, Chronic Obstructive/drug therapy
PMC - PMC8933108
COIS- The authors declare no conflict of interest.
EDAT- 2022/03/22 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/03/11
CRDT- 2022/03/21 08:48
PHST- 2021/10/30 00:00 [received]
PHST- 2022/02/01 00:00 [revised]
PHST- 2022/02/11 00:00 [accepted]
PHST- 2022/03/21 08:48 [entrez]
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/03/11 00:00 [pmc-release]
AID - 10.1155/2022/5058121 [doi]
PST - epublish
SO  - Biomed Res Int. 2022 Mar 11;2022:5058121. doi: 10.1155/2022/5058121. eCollection 
      2022.