PMID- 35309307 OWN - NLM STAT- MEDLINE DCOM- 20220502 LR - 20220502 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 13 DP - 2022 TI - Impact of HLA Epitope Matching on Outcomes After Unrelated Bone Marrow Transplantation. PG - 811733 LID - 10.3389/fimmu.2022.811733 [doi] LID - 811733 AB - The significance of antibody-identified epitopes stimulating humoral alloimmunity is not well understood in the identification of non-permissive human leukocyte antigen (HLA) mismatching patterns in hematopoietic stem cell transplantation (HSCT). This was a retrospective study in a cohort of 9,991 patients who underwent their first HSCT for hematologic malignancies from unrelated bone marrow donors in the Transplant Registry Unified Management Program (TRUMP). HLA eplet mismatches (EMM) were quantified using HLAMatchmaker (HLAMM). The median age of patients was 48 years (range, 16 to 77). The number of EMM in recipient-donor pairs in our study population ranged from 0 to 37 in HLA class I (median, 0) and 0 to 60 in HLA class II (median, 1). In addition to the known high-risk mismatch patterns in the Japanese cohort, HLA-C EMM in the GVH direction was associated with a significantly higher risk for grade III-IV aGVHD, leading to a higher risk of non-relapse mortality and lower overall survival (compared with HLA-C matched patients, HR 1.67, 95% CI 1.44-1.95; HR 1.39, 95% CI 1.25-1.54; HR 1.20, 95% CI 1.10-1.30, respectively). HLAMM-based epitope matching might be useful for identifying patients who are at high risk for serious complications after HSCT from HLA mismatched unrelated donors. CI - Copyright (c) 2022 Iwasaki, Kanda, Tanaka, Shindo, Sato, Doki, Fukuda, Ozawa, Eto, Uchida, Katayama, Kataoka, Ara, Ota, Onizuka, Kanda, Ichinohe, Atsuta and Morishima. FAU - Iwasaki, Makoto AU - Iwasaki M AD - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Kanda, Junya AU - Kanda J AD - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Tanaka, Hidenori AU - Tanaka H AD - HLA Foundation Laboratory, Kyoto, Japan. FAU - Shindo, Takero AU - Shindo T AD - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. FAU - Sato, Takahiko AU - Sato T AD - Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Doki, Noriko AU - Doki N AD - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan. FAU - Fukuda, Takahiro AU - Fukuda T AD - Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan. FAU - Ozawa, Yukiyasu AU - Ozawa Y AD - Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan. FAU - Eto, Tetsuya AU - Eto T AD - Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan. FAU - Uchida, Naoyuki AU - Uchida N AD - Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Tokyo, Japan. FAU - Katayama, Yuta AU - Katayama Y AD - Department of Hematology, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan. FAU - Kataoka, Keisuke AU - Kataoka K AD - Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. FAU - Ara, Takahide AU - Ara T AD - Department of Hematology, Hokkaido University Hospital, Sapporo, Japan. FAU - Ota, Shuichi AU - Ota S AD - Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan. FAU - Onizuka, Makoto AU - Onizuka M AD - Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan. FAU - Kanda, Yoshinobu AU - Kanda Y AD - Division of Hematology, Jichi Medical University, Tochigi, Japan. FAU - Ichinohe, Tatsuo AU - Ichinohe T AD - Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan. FAU - Atsuta, Yoshiko AU - Atsuta Y AD - Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan. AD - Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan. FAU - Morishima, Satoko AU - Morishima S AD - Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220303 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Epitopes) RN - 0 (HLA Antigens) RN - 0 (HLA-C Antigens) SB - IM MH - Adolescent MH - Adult MH - Aged MH - *Bone Marrow Transplantation/adverse effects MH - Epitopes MH - HLA Antigens/genetics MH - *HLA-C Antigens MH - Histocompatibility Testing MH - Humans MH - Middle Aged MH - Retrospective Studies MH - Young Adult PMC - PMC8928463 OTO - NOTNLM OT - HLAMatchmaker OT - acute GVHD OT - epitope OT - high-risk mismatch OT - unrelated bone marrow transplantation COIS- JK reports grants from AMED (Grant Number: JP18pc0101031), grants from JSPS KAKENHI (Grant Number 18K08325 and 21K08391), grants from Takeda Science Foundation, during the conduct of the study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest EDAT- 2022/03/22 06:00 MHDA- 2022/05/03 06:00 PMCR- 2022/01/01 CRDT- 2022/03/21 08:50 PHST- 2021/11/09 00:00 [received] PHST- 2022/02/14 00:00 [accepted] PHST- 2022/03/21 08:50 [entrez] PHST- 2022/03/22 06:00 [pubmed] PHST- 2022/05/03 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2022.811733 [doi] PST - epublish SO - Front Immunol. 2022 Mar 3;13:811733. doi: 10.3389/fimmu.2022.811733. eCollection 2022.