PMID- 35309939
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221111
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 10
DP  - 2022
TI  - The Role of Non-Coding RNAs in Autophagy During Carcinogenesis.
PG  - 799392
LID - 10.3389/fcell.2022.799392 [doi]
LID - 799392
AB  - Macroautophagy (autophagy herein) is a cellular stress response and a survival 
      pathway involved in self-renewal and quality control processes to maintain 
      cellular homeostasis. The alteration of autophagy has been implicated in numerous 
      diseases such as cancer where it plays a dual role. Autophagy serves as a tumor 
      suppressor in the early phases of cancer formation with the restoration of 
      homeostasis and eliminating cellular altered constituents, yet in later phases, 
      autophagy may support and/or facilitate tumor growth, metastasis and may 
      contribute to treatment resistance. Key components of autophagy interact with 
      either pro- and anti-apoptotic factors regulating the proximity of tumor cells to 
      apoptotic cliff promoting cell survival. Autophagy is regulated by key cell 
      signaling pathways such as Akt (protein kinase B, PKB), mammalian target of 
      rapamycin (mTOR) and AMP-activated protein kinase (AMPK) involved in cell 
      survival and metabolism. The expression of critical members of upstream cell 
      signaling, as well as those directly involved in the autophagic and apoptotic 
      machineries are regulated by microRNAs (miRNAs) and long non-coding RNAs 
      (lncRNAs). Consequently, non-coding RNAs play a relevant role in carcinogenesis 
      and treatment response in cancer. The review is an update of the current 
      knowledge in the regulation by miRNA and lncRNA of the autophagic components and 
      their functional impact to provide an integrated and comprehensive regulatory 
      network of autophagy in cancer.
CI  - Copyright (c) 2022 de la Cruz-Ojeda, Flores-Campos, Navarro-Villaran and Muntane.
FAU - de la Cruz-Ojeda, Patricia
AU  - de la Cruz-Ojeda P
AD  - Institute of Biomedicine of Seville (IBiS), Hospital University "Virgen del 
      Rocio"/CSIC/University of Seville, Seville, Spain.
AD  - Department of Medical Physiology and Biophysics, University of Seville, Seville, 
      Spain.
AD  - Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o 
      Ciberehd), Institute of Health Carlos III, Madrid, Spain.
FAU - Flores-Campos, Rocio
AU  - Flores-Campos R
AD  - Institute of Biomedicine of Seville (IBiS), Hospital University "Virgen del 
      Rocio"/CSIC/University of Seville, Seville, Spain.
FAU - Navarro-Villaran, Elena
AU  - Navarro-Villaran E
AD  - Institute of Biomedicine of Seville (IBiS), Hospital University "Virgen del 
      Rocio"/CSIC/University of Seville, Seville, Spain.
AD  - Department of Medical Physiology and Biophysics, University of Seville, Seville, 
      Spain.
AD  - Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o 
      Ciberehd), Institute of Health Carlos III, Madrid, Spain.
FAU - Muntane, Jordi
AU  - Muntane J
AD  - Institute of Biomedicine of Seville (IBiS), Hospital University "Virgen del 
      Rocio"/CSIC/University of Seville, Seville, Spain.
AD  - Department of Medical Physiology and Biophysics, University of Seville, Seville, 
      Spain.
AD  - Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o 
      Ciberehd), Institute of Health Carlos III, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220302
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC8926078
OTO - NOTNLM
OT  - autophagy
OT  - beclin-1
OT  - cancer
OT  - lncRNA
OT  - miRNA
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/22 06:00
MHDA- 2022/03/22 06:01
PMCR- 2022/01/01
CRDT- 2022/03/21 08:56
PHST- 2021/10/21 00:00 [received]
PHST- 2022/01/18 00:00 [accepted]
PHST- 2022/03/21 08:56 [entrez]
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/03/22 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 799392 [pii]
AID - 10.3389/fcell.2022.799392 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2022 Mar 2;10:799392. doi: 10.3389/fcell.2022.799392. 
      eCollection 2022.