PMID- 35310987
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220322
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Endovascular Excimer Laser-Assisted Balloon Angioplasty for Infrapopliteal 
      Arteries in Thromboangiitis Obliterans: A Treatment for Acute-Phase TAO.
PG  - 831340
LID - 10.3389/fcvm.2022.831340 [doi]
LID - 831340
AB  - BACKGROUND: Thromboangiitis obliterans (TAO, Buerger's disease) is an 
      inflammatory and obstructive vasculopathy, which leads to limb ischemic rest pain 
      and ulcerations in the acute stage. OBJECTIVES: This study aimed to assess the 
      feasibility of excimer laser-assisted balloon angioplasty (BA) for patients with 
      acute infrapopliteal TAO. METHOD: This was a single-center retrospective cohort 
      study. In this study, 220 patients with 210 target limbs between January 2012 and 
      September 2021 were involved. Among them, 52 target limbs have received 
      endovascular excimer laser-assisted balloon angioplasty from January 2017. The 
      ankle brachial index (ABI), rest pain score, ulcer, Rutherford classification, 
      and TASC II classification were assessed. The follow-up time was 6 months. 
      RESULTS: The technical success rate of laser + BA and BA groups was 71.15 and 
      65.82% (p = 0.5021), respectively. After intervention, the ABI of two groups were 
      0.85 +/- 0.20 and 0.77 +/- 0.20 (p = 0.0419), and the rest pain score was 1.00 +/- 1.43 
      and 1.71 +/- 2.25 (p = 0.0449). During the 6 months follow-up, the ABI of two 
      groups was 0.76 +/- 0.17 and 0.75 +/- 0.23 (p = 0.8539), the rest pain score was 1.43 
      +/- 1.82 and 2.24 +/- 2.06 (p = 0.0783), and the ulcer rate was 23.68 and 40.98% (p = 
      0.0867), respectively. The proportion of patients who were assessed as TASC II 
      C/D or Rutherford 4-6 in laser +BA group was significantly lower than that in BA 
      group, indicating that the former had better efficacy. The rate of critical limb 
      ischemia and restenosis in the laser +BA group was lower than that in the BA 
      group (47.36 vs. 67.22%; 21.05 vs. 34.43%) during follow-up. In the laser + BA 
      group, the reintervention rate was lower than that in the BA group (2.70 vs. 
      8.20%, p = 0.0425). No serious adverse events (AEs) occurred. CONCLUSION: Excimer 
      laser debulking-assisted angioplasty is a feasible, effective, and safe method to 
      treat acute infrapopliteal TAO.
CI  - Copyright (c) 2022 Pu, Jiang, Wu, Lei, Hu, Qiu, Zhang, Huang, Lu, Yin and Zhao.
FAU - Pu, Hongji
AU  - Pu H
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Jiang, Yihong
AU  - Jiang Y
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Wu, Zhaoyu
AU  - Wu Z
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Lei, Jiahao
AU  - Lei J
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Hu, Jiateng
AU  - Hu J
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Qiu, Peng
AU  - Qiu P
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Zhang, Xing
AU  - Zhang X
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Huang, Qun
AU  - Huang Q
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Lu, Xinwu
AU  - Lu X
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Yin, Minyi
AU  - Yin M
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Zhao, Zhen
AU  - Zhao Z
AD  - Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
LA  - eng
PT  - Case Reports
DEP - 20220304
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8931023
OTO - NOTNLM
OT  - Buerger's disease
OT  - angioplasty
OT  - endovascular treatment
OT  - excimer laser
OT  - thromboangiitis obliterans (TAO)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The handling editor YZ declared a shared affiliation with 
      several of the authors HP, YJ, ZW, JL, JH, PQ, XZ, QH, XL, MY and ZZ at time of 
      review.
EDAT- 2022/03/22 06:00
MHDA- 2022/03/22 06:01
PMCR- 2022/01/01
CRDT- 2022/03/21 09:10
PHST- 2021/12/08 00:00 [received]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2022/03/21 09:10 [entrez]
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/03/22 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.831340 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Mar 4;9:831340. doi: 10.3389/fcvm.2022.831340. 
      eCollection 2022.