PMID- 35311100
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220322
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 12
DP  - 2022
TI  - A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal 
      Squamous Cell Carcinoma.
PG  - 786207
LID - 10.3389/fonc.2022.786207 [doi]
LID - 786207
AB  - PURPOSE: Lymph node metastasis (LNM) has a negative impact on the survival of 
      patients with laryngeal squamous cell carcinoma (LSCC). Supraglottic LSCC is the 
      most common cause of cervical lymph node metastases due to the extensive 
      submucosal lymphatic plexus. The accurate evaluation of LNM before surgery can 
      inform improved decisions in the clinic. In this study, we aimed to construct a 
      nomogram to predict LNM in primary supraglottic LSCC patients. METHODS: The data 
      from 314 patients with clinico-pathological confirmed supraglottic LSCC who 
      underwent partial or total laryngectomy in our department from 2016 to 2020 were 
      retrospectively analyzed (243 cases in the training set and 71 cases in the 
      validation set). A multivariate logistic regression model was used to screen out 
      independent risk factors and a nomogram was established. The accuracy and 
      discrimination ability of the nomogram was evaluated using a consistency index 
      and calibration curves. RESULTS: Tumor size, tumor differentiation degree and LMR 
      (lymphocyte-monocyte ratio) were selected to construct the nomogram. The C-index 
      was 0.731 in the training set and 0.707 in the validation set. The calibration 
      curves of the training and validation group both exhibited close agreement 
      between the predicted and the actual presence of LNM. CONCLUSIONS: A nomogram was 
      established based on routinely measured pretreatment variables and the predicted 
      results improved the management of patients with LNM.
CI  - Copyright (c) 2022 Song, Heng, Hsueh, Huang, Tao, Zhou and Zhang.
FAU - Song, Lulu
AU  - Song L
AD  - Department of Otolaryngology, Shanghai Key Clinical Disciplines of 
      Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
FAU - Heng, Yu
AU  - Heng Y
AD  - Department of Otolaryngology, Shanghai Key Clinical Disciplines of 
      Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
FAU - Hsueh, Chi-Yao
AU  - Hsueh CY
AD  - Department of Otolaryngology, Shanghai Key Clinical Disciplines of 
      Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
FAU - Huang, Huiying
AU  - Huang H
AD  - Department of Otolaryngology, Shanghai Key Clinical Disciplines of 
      Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otolaryngology, Shanghai Key Clinical Disciplines of 
      Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otolaryngology, Shanghai Key Clinical Disciplines of 
      Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Otolaryngology, Shanghai Key Clinical Disciplines of 
      Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20220302
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC8924667
OTO - NOTNLM
OT  - C-index
OT  - diagnosis
OT  - lymph node metastasis
OT  - nomogram
OT  - supraglottic squamous cell laryngeal cancer
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/03/22 06:00
MHDA- 2022/03/22 06:01
PMCR- 2022/01/01
CRDT- 2022/03/21 09:11
PHST- 2021/09/29 00:00 [received]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/03/21 09:11 [entrez]
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/03/22 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2022.786207 [doi]
PST - epublish
SO  - Front Oncol. 2022 Mar 2;12:786207. doi: 10.3389/fonc.2022.786207. eCollection 
      2022.