PMID- 35311718
OWN - NLM
STAT- MEDLINE
DCOM- 20220823
LR  - 20220823
IS  - 1878-6448 (Electronic)
IS  - 1053-8135 (Linking)
VI  - 51
IP  - 1
DP  - 2022
TI  - Effect and mechanism of mirror therapy on lower limb rehabilitation after 
      ischemic stroke: A fMRI study.
PG  - 65-77
LID - 10.3233/NRE-210307 [doi]
AB  - BACKGROUND: Mirror therapy has been gradually adopted for lower limb 
      rehabilitation, but its efficacy and neural mechanism are not well understood. 
      OBJECTIVE: This study aims to investigate the effect and neural mechanism of 
      mirror therapy on lower limb rehabilitation after ischemic stroke by using 
      resting state functional magnetic resonance imaging (rs-fMRI). METHODS: A 
      single-blind and randomized controlled pilot study was conducted. 32 patients 
      with ischemic stroke were included in this study and randomly divided into two 
      groups - the control group (CT, n = 16) and the mirror therapy group (MT, 
      n = 16). Both the CT and MT groups received medication and routine rehabilitation 
      training. In addition, mirror therapy was added to the MT group 5 times a week 
      for 30 minutes each time over a period of 3 weeks. Patients' motor functions, 
      functional connectivity (FC), regional homogeneity (ReHo), and fractional 
      amplitude of low-frequency fluctuations (fALFF) were analyzed both before and 
      immediately after the treatment. RESULTS: Patients' motor functions showed 
      significant improvement in both groups compared to those before treatment 
      (p < 0.01). Moreover, the MT group showed significantly better improvement than 
      the CT group after the treatment (p < 0.05). FC, ReHo and fALFF indicated 
      enhanced neuronal activities in motor function-related brain regions in the MT 
      group compared to the CT group. CONCLUSION: Mirror therapy promotes the recovery 
      of lower limb motor functions in patients with ischemic stroke. Through the 
      comparative rs-fMRI analysis, it is found that the mirror therapy promotes the 
      functional reorganization of the injured brain.
FAU - Cui, Wei
AU  - Cui W
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
FAU - Huang, Lin
AU  - Huang L
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
FAU - Tian, Yang
AU  - Tian Y
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
FAU - Luo, Hong
AU  - Luo H
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
FAU - Chen, Shuang
AU  - Chen S
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
FAU - Yang, Yan
AU  - Yang Y
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
FAU - Li, Yamei
AU  - Li Y
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
FAU - Fu, Jing
AU  - Fu J
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
FAU - Yu, Qian
AU  - Yu Q
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
FAU - Xu, Li
AU  - Xu L
AD  - Department of Rehabilitation Medicine, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Sichuan, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Netherlands
TA  - NeuroRehabilitation
JT  - NeuroRehabilitation
JID - 9113791
SB  - IM
MH  - Humans
MH  - *Ischemic Stroke
MH  - Lower Extremity/diagnostic imaging
MH  - Magnetic Resonance Imaging
MH  - Mirror Movement Therapy
MH  - Recovery of Function/physiology
MH  - Single-Blind Method
MH  - *Stroke
MH  - *Stroke Rehabilitation/methods
MH  - Treatment Outcome
MH  - Upper Extremity
OTO - NOTNLM
OT  - Ischemic stroke
OT  - lower limb rehabilitation
OT  - mirror therapy
OT  - resting-state functional magnetic resonance imaging (rs-fMRI)
EDAT- 2022/03/22 06:00
MHDA- 2022/08/24 06:00
CRDT- 2022/03/21 12:16
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/08/24 06:00 [medline]
PHST- 2022/03/21 12:16 [entrez]
AID - NRE210307 [pii]
AID - 10.3233/NRE-210307 [doi]
PST - ppublish
SO  - NeuroRehabilitation. 2022;51(1):65-77. doi: 10.3233/NRE-210307.