PMID- 35312104
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220716
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 36
IP  - 5
DP  - 2022 May
TI  - New body mass index for predicting prognosis in patients with antineutrophil 
      cytoplasmic antibody-associated vasculitis.
PG  - e24357
LID - 10.1002/jcla.24357 [doi]
LID - e24357
AB  - OBJECTIVES: Body mass index (BMI) is a known indicator of all-cause mortality. 
      However, conventional BMI does not reflect the three-dimensional human body. To 
      overcome this limitation, a new BMI has been proposed that provides a closer 
      approximation of real human body shape. This study investigated the associations 
      between the new BMI and poor outcomes in patients with antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV). METHOD: We retrospectively reviewed the 
      medical records of 242 patients with AAV in a single tertiary medical center. 
      Based on the new BMI, the patients were categorized into four groups: underweight 
      (<18.5 kg/m(2.5) ), healthy weight (18.5 to <25.0 kg/m(2.5) ), overweight (25.0 
      to <30.0 kg/m(2.5) ), and obese (>/=30.0 kg/m(2.5) ). The association among the new 
      BMI and death, relapse, end-stage renal disease (ESRD) development, 
      cerebrovascular accident, and cardiovascular disease was analyzed. RESULTS: The 
      underweight group, according to the new BMI, had higher hazard ratios (HRs) for 
      all-cause mortality (HR: 3.180, 95% confidence interval [CI]: 1.134-8.922, 
      p = 0.028), relapse (HR: 2.141, 95% CI: 1.019-4.368, p = 0.036), and ESRD 
      development (HR: 2.729, 95% CI: 1.190-6.259, p = 0.018) than the healthy weight 
      group. However, according to the conventional BMI, there were no differences in 
      the risks for all poor outcomes between the underweight and healthy weight 
      groups. Multivariate logistic regression analysis demonstrated that being 
      underweight, according to the new BMI, was an independent risk factor for 
      all-cause mortality (HR: 5.285; 95% CI: 1.468-19.018; p = 0.011). CONCLUSION: 
      Being underweight, according to the new BMI, is associated with poor outcomes in 
      patients with AAV.
CI  - (c) 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Pyo, Jung Y
AU  - Pyo JY
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Ahn, Sung S
AU  - Ahn SS
AUID- ORCID: 0000-0002-9002-9880
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Lee, Lucy E
AU  - Lee LE
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Song, Jason J
AU  - Song JJ
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea.
FAU - Park, Yong-Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea.
FAU - Lee, Sang-Won
AU  - Lee SW
AUID- ORCID: 0000-0002-8038-3341
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea.
LA  - eng
GR  - HI14C1324/Korea Health Industry Development Institute/Republic of Korea
GR  - 6-2019-0184/Yonsei University College of Medicine/
PT  - Journal Article
DEP - 20220321
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/epidemiology
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Body Mass Index
MH  - Female
MH  - Humans
MH  - *Kidney Failure, Chronic
MH  - Male
MH  - Prognosis
MH  - Recurrence
MH  - Retrospective Studies
MH  - Thinness/complications/epidemiology
PMC - PMC9102757
OTO - NOTNLM
OT  - antineutrophil cytoplasmic antibody-associated vasculitis
OT  - conventional BMI
OT  - new BMI
OT  - poor outcomes
OT  - underweight
COIS- The authors declare that they have no conflicts of interests.
EDAT- 2022/03/22 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/03/21
CRDT- 2022/03/21 12:18
PHST- 2022/03/03 00:00 [revised]
PHST- 2022/01/25 00:00 [received]
PHST- 2022/03/06 00:00 [accepted]
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/03/21 12:18 [entrez]
PHST- 2022/03/21 00:00 [pmc-release]
AID - JCLA24357 [pii]
AID - 10.1002/jcla.24357 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2022 May;36(5):e24357. doi: 10.1002/jcla.24357. Epub 2022 Mar 
      21.