PMID- 35312231
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220720
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 99
IP  - 6
DP  - 2022 May
TI  - Mitral valve edge-to-edge repair versus indirect mitral valve annuloplasty in 
      atrial functional mitral regurgitation.
PG  - 1839-1847
LID - 10.1002/ccd.30157 [doi]
AB  - OBJECTIVES: We aimed to compare indirect mitral annuloplasty using the Carillon 
      Mitral Contour System and edge-to-edge repair via MitraClip in atrial functional 
      mitral regurgitation (aFMR). BACKGROUND: In patients with left ventricular 
      dilation, both edge-to-edge repair and indirect mitral annuloplasty are effective 
      in reducing mitral regurgitation, while no clinical trial has compared both 
      interventional methods in aFMR. METHODS: In a retrospective single-center 
      analysis, 41 patients with aFMR underwent either edge-to-edge mitral valve repair 
      (MitraClip group, n = 20) or indirect annuloplasty (Carillon group, n = 21). 
      RESULTS: Both treatment groups showed high procedural success (100%) and low 
      complication rates. Both treatment groups showed a comparable reduction of New 
      York Heart Association (NYHA) classification postimplantation, after 3- and 
      12-months follow-up. Quantitative reduction in echocardiographic FMR parameters 
      was significantly pronounced in the MitraClip group (reduction in vena contracta 
      MitraClip vs. Carillon: postimplantation -74.6 +/- 25.8 vs. -29.1 +/- 17.8%, 3-months 
      follow-up -65.8 +/- 31.2 vs. -33.9 +/- 17.5%, 12-months follow-up -50.8 +/- 27.9 vs. 
      -23.9 +/- 17.0%, p < 0.05). Qualitative mitral valve assessment showed improved FMR 
      class postimplantation, at 3-and 12-months follow-up in both treatment groups. 
      Edge-to-edge repair revealed better results with lower average FMR classification 
      compared to indirect coronary sinus-based annuloplasty. After 12-months left 
      atrial (LA) volume was significantly reduced in the Carillon group, while in the 
      MitraClip group no LA remodeling was found (reduction in LA volume MitraClip vs. 
      Carillon at 12 months: +9.6 +/- 25.1% vs. -12.3 +/- 12.7%, p < 0.05). CONCLUSIONS: 
      Both indirect mitral valve annuloplasty and edge-to-edge repair are feasible and 
      safe in patients with aFMR, while the reduction in FMR was pronounced in the 
      edge-to-edge repair group.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Rottlander, Dennis
AU  - Rottlander D
AUID- ORCID: 0000-0002-8789-9092
AD  - Department of Cardiology, Rheinland Klinikum Neuss, Neuss, Germany.
AD  - Department of Cardiology, Krankenhaus Porz am Rhein, Cologne, Germany.
AD  - Faculty of Health, School of Medicine, University Witten/Herdecke, Witten, 
      Germany.
FAU - Golabkesh, Milad
AU  - Golabkesh M
AD  - Department of Cardiology, Rheinland Klinikum Neuss, Neuss, Germany.
FAU - Degen, Hubertus
AU  - Degen H
AD  - Department of Cardiology, Rheinland Klinikum Neuss, Neuss, Germany.
FAU - Ogutcu, Alev
AU  - Ogutcu A
AD  - Department of Cardiology, Rheinland Klinikum Neuss, Neuss, Germany.
FAU - Saal, Martin
AU  - Saal M
AD  - Department of Cardiology, Rheinland Klinikum Neuss, Neuss, Germany.
FAU - Haude, Michael
AU  - Haude M
AD  - Department of Cardiology, Rheinland Klinikum Neuss, Neuss, Germany.
LA  - eng
PT  - Journal Article
DEP - 20220321
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
MH  - *Heart Valve Prosthesis Implantation/adverse effects/methods
MH  - Humans
MH  - Mitral Valve/diagnostic imaging/surgery
MH  - *Mitral Valve Annuloplasty/adverse effects/methods
MH  - *Mitral Valve Insufficiency/diagnostic imaging/surgery
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - HF-heart failure
OT  - ITTE-imaging
OT  - MVD-mitral valve disease
OT  - MVPI-mitral valve disease
OT  - SHDI-structural heart disease intervention
OT  - TTE/TEE
OT  - percutaneous intervention
EDAT- 2022/03/22 06:00
MHDA- 2022/05/18 06:00
CRDT- 2022/03/21 12:20
PHST- 2021/11/25 00:00 [received]
PHST- 2022/03/05 00:00 [accepted]
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/03/21 12:20 [entrez]
AID - 10.1002/ccd.30157 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2022 May;99(6):1839-1847. doi: 10.1002/ccd.30157. 
      Epub 2022 Mar 21.