PMID- 35312785
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220919
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 23
IP  - 9
DP  - 2022 Aug 31
TI  - The Modifying of Functional Connectivity Induced by Peripheral Nerve Field 
      Stimulation using Electroacupuncture for Migraine: A Prospective Clinical Study.
PG  - 1560-1569
LID - 10.1093/pm/pnac048 [doi]
AB  - OBJECTIVE: We examined the functional connectivity (FC) in patients with migraine 
      compared with healthy subjects before and after C2 peripheral nerve field 
      stimulation with electroacupuncture (EA-C2-PNfS) to evaluate the effect of 
      EA-C2-PNfS and elucidate the mechanism of migraine. METHODS: Twenty-six patients 
      with migraine and 24 healthy controls were recruited. All patients underwent 
      resting state functional magnetic resonance imaging before and after 3 months of 
      EA-C2-PNfS. We evaluated a numerical rating scale, the Headache Impact Test, and 
      the Self-Rating Depression Scale, which assesses depression. Healthy controls 
      underwent magnetic resonance imaging twice at a 3-month interval without 
      acupuncture. An analysis of FC in the region of interest in the pain matrix was 
      performed. RESULTS: Twenty patients with migraine and 23 healthy controls 
      (mean +/- standard deviation: 44.9 +/- 12.9 years of age) were included. Three 
      patients had migraine with aura (55.0 +/- 18.0 years of age), 11 patients had 
      migraine without aura (MWoA) (45.6 +/- 14.6 years of age), and six patients had 
      chronic migraine (40.8 +/- 13.9 years of age). The clinical assessments 
      significantly improved after EA-C2-PNfS in the MWoA group only. In FC analysis, 
      the MWoA group showed a significant decrease after EA-C2-PNfS in FC between the 
      right hypothalamus and left insula. Right hypothalamus-related FC was lower 
      before acupuncture in the chronic migraine group than in the MWoA group. 
      CONCLUSION: After EA-C2-PNfS for MWoA, significant changes in FC were observed at 
      the hypothalamus and insula. Our results indicate that EA-C2-PNfS could improve 
      migraine headache by modifying pain-related FC.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      American Academy of Pain Medicine. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Ishiyama, Sumire
AU  - Ishiyama S
AUID- ORCID: 0000-0003-1650-6885
AD  - Faculty of Health Sciences, Tsukuba University of Technology, Tsukuba, Ibaraki, 
      Japan.
AD  - Graduate School of Comprehensive Human Sciences, Doctoral Program in Clinical 
      Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
FAU - Shibata, Yasushi
AU  - Shibata Y
AD  - Department of Neurosurgery, Headache Clinic, University of Tsukuba, Mito Medical 
      Center, Mito Kyodo General Hospital, Mito, Ibaraki, Japan.
AD  - Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, 
      Ibaraki, Japan.
FAU - Ayuzawa, Satoshi
AU  - Ayuzawa S
AD  - Faculty of Health Sciences, Tsukuba University of Technology, Tsukuba, Ibaraki, 
      Japan.
FAU - Matsushita, Akira
AU  - Matsushita A
AD  - Neurorehabilitation, Ibaraki Prefectural University of Health Sciences, Ami, 
      Ibaraki, Japan.
FAU - Matsumura, Akira
AU  - Matsumura A
AD  - Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, 
      Ibaraki, Japan.
AD  - Ibaraki Prefectural University of Health Sciences, Ami, Ibaraki, Japan.
FAU - Ishikawa, Eiichi
AU  - Ishikawa E
AD  - Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, 
      Ibaraki, Japan.
LA  - eng
SI  - UMIN-CTR/000028222
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
MH  - Brain
MH  - *Electroacupuncture
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - *Migraine without Aura
MH  - Pain
MH  - Peripheral Nerves
MH  - Prospective Studies
OTO - NOTNLM
OT  - Acupuncture
OT  - Functional Connectivity
OT  - Migraine
OT  - Peripheral Nerve Field Stimulation
EDAT- 2022/03/22 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/03/21 17:18
PHST- 2021/08/31 00:00 [received]
PHST- 2022/03/04 00:00 [revised]
PHST- 2022/03/17 00:00 [accepted]
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/03/21 17:18 [entrez]
AID - 6551259 [pii]
AID - 10.1093/pm/pnac048 [doi]
PST - ppublish
SO  - Pain Med. 2022 Aug 31;23(9):1560-1569. doi: 10.1093/pm/pnac048.