PMID- 35313094
OWN - NLM
STAT- MEDLINE
DCOM- 20220706
LR  - 20220711
IS  - 2300-9020 (Electronic)
IS  - 1644-387X (Linking)
VI  - 59
IP  - 2
DP  - 2022 Apr-Jun
TI  - Influence of chronic hyperhomocysteinemia on the features of bone metabolism in 
      the case of lipopolysaccharide-induced periodontitis.
PG  - 255-261
LID - 10.17219/dmp/143948 [doi]
AB  - BACKGROUND: Periodontal disease is the second most common oral health problem 
      after dental caries. This increasing prevalence makes it not only a health 
      problem, but also a social issue. The pathogenesis of periodontal disease is 
      associated with a number of adverse exogenous and endogenous factors, including 
      hyperhomocysteinemia (HHcy). OBJECTIVES: This study aimed to determine the 
      features of bone metabolism in rats with lipopolysaccharide (LPS)-induced 
      periodontitis combined with chronic thiolactone HHcy. MATERIAL AND METHODS: 
      Forty-eight white, non-linear, mature rats were divided into 4 groups: control (n 
      = 12); LPS‑induced periodontitis (n = 12); chronic thiolactone HHcy (n = 12); and 
      periodontitis combined with HHcy (n = 12). The rats were sacrificed the day after 
      the last LPS injection or the day after the last homocysteine (Hcy) thiolactone 
      administration. Bone metabolism was determined based on the activity of alkaline 
      phosphatase (ALP) and acid phosphatase (AP) in blood serum and periodontal 
      homogenate. RESULTS: A decrease in ALP activity (by 40.1%; small er, Cyrillic = 0.001) and the 
      mineralization index (MI) (3.5 times; small er, Cyrillic < 0.001) with an increase in AP activity 
      (2.0 times; small er, Cyrillic < 0.001) was observed in the periodontal homogenate of rats with 
      LPS‑induced periodontitis. In the case of LPS‑induced periodontitis combined with 
      chronic thiolactone HHcy, more pronounced changes in the activity of phosphatases 
      and in MI were established as compared to rats with LPS‑induced periodontitis 
      only. CONCLUSIONS: Chronic thiolactone HHcy enhances disturbances in bone 
      metabolism in LPS‑induced periodontitis. The osteotoxic effect of HHcy is 
      associated with the activation of osteoclastogenesis and enhanced bone 
      resorption. However, further research is required on the subject.
FAU - Khudan, Roman
AU  - Khudan R
AD  - Department of Dental Therapy, Faculty of Dentistry, Ivan Horbachevsky Ternopil 
      National Medical University, Ukraine.
FAU - Krynytska, Inna
AU  - Krynytska I
AD  - Department of Functional and Laboratory Diagnostics, Faculty of Medicine, Ivan 
      Horbachevsky Ternopil National Medical University, Ukraine.
FAU - Marushchak, Mariya
AU  - Marushchak M
AD  - Department of Functional and Laboratory Diagnostics, Faculty of Medicine, Ivan 
      Horbachevsky Ternopil National Medical University, Ukraine.
FAU - Korda, Mykhaylo
AU  - Korda M
AD  - Department of Medical Biochemistry, Faculty of Medicine, Ivan Horbachevsky 
      Ternopil National Medical University, Ukraine.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Dent Med Probl
JT  - Dental and medical problems
JID - 101205669
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Animals
MH  - *Dental Caries
MH  - *Hyperhomocysteinemia/chemically induced/complications/metabolism
MH  - Lipopolysaccharides/adverse effects
MH  - *Periodontitis
MH  - Rats
OTO - NOTNLM
OT  - bone metabolism
OT  - hyperhomocysteinemia
OT  - periodontitis
EDAT- 2022/03/22 06:00
MHDA- 2022/07/07 06:00
CRDT- 2022/03/21 17:20
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
PHST- 2022/03/21 17:20 [entrez]
AID - 10.17219/dmp/143948 [doi]
PST - ppublish
SO  - Dent Med Probl. 2022 Apr-Jun;59(2):255-261. doi: 10.17219/dmp/143948.