PMID- 35313392
OWN - NLM
STAT- MEDLINE
DCOM- 20220711
LR  - 20220711
IS  - 0034-8376 (Print)
IS  - 0034-8376 (Linking)
VI  - 74
IP  - 3
DP  - 2022 May 2
TI  - Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?
PG  - 147-155
LID - 10.24875/RIC.21000603 [doi]
AB  - BACKGROUND: The inflammatory response in gout disease is induced by the 
      activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway 
      mediated by IL-1beta release. OBJECTIVE: The objective of the study was to determine 
      the association between single nucleotide polymorphisms (SNPs) within NLRP3 
      inflammasome genes and gout susceptibility. METHODS: Mexican patients with gout 
      from the National Rehabilitation Institute and General Hospital of Mexico were 
      enrolled. A healthy control group was also included. We analyzed the frequency 
      and allelic distribution of eight SNPs from seven different genes within the 
      NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 
      rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1beta rs1143623, P2RX7 rs3751142, 
      and PPARGC1B rs45520937 SNPs. RESULTS: We found that the SNP rs45520937 of 
      PPARGC1B was associated with the risk of developing gout when it was analyzed 
      using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 
      1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 
      rs2569190 polymorphism could be associated with a lower risk of gout under an 
      additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant 
      associations were identified for the remaining SNPs. CONCLUSION: Our findings 
      suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility.
FAU - Clavijo-Cornejo, Denise
AU  - Clavijo-Cornejo D
AD  - Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de 
      Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
FAU - Lopez-Reyes, Alberto
AU  - Lopez-Reyes A
AD  - Gerosciences Laboratory, Instituto Nacional de Rehabilitacion Luis Guillermo 
      Ibarra Ibarra, Mexico City, Mexico.
FAU - Cruz-Arenas, Esteban
AU  - Cruz-Arenas E
AD  - Hospital Epidemiological Surveillance Unit, Instituto Nacional de Rehabilitacion 
      Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
FAU - Jacobo-Albavera, Leonor
AU  - Jacobo-Albavera L
AD  - Laboratory of Cardiovascular Genomics, Instituto Nacional de Medicina Genomica, 
      Mexico City, Mexico.
FAU - Rivera-Tlaltzicapa, Daniel
AU  - Rivera-Tlaltzicapa D
AD  - Universidad Autonoma Metropolitana, Mexico City, Mexico.
FAU - Francisco-Balderas, Adriana
AU  - Francisco-Balderas A
AD  - Graduate Studies Department, Escuela Superior de Medicina, Instituto Politecnico 
      Nacional, Mexico City, Mexico.
FAU - Dominguez-Perez, Mayra
AU  - Dominguez-Perez M
AD  - Universidad Estatal del Valle de Ecatepec, Mexico City, Mexico.
FAU - Romero-Morelos, Pablo
AU  - Romero-Morelos P
AD  - Rheumatology Department, Hospital General de Mexico, Mexico City, Mexico.
FAU - Vazquez-Mellado, Janitzia
AU  - Vazquez-Mellado J
AD  - Rheumatology Department, Instituto Nacional de Cardiolog a Ignacio Ch vez, Mexico 
      City, Mexico.
FAU - Silveira, Luis H
AU  - Silveira LH
AD  - Synovial Fluid Laboratory, Instituto Nacional de Rehabilitaci n LGII, Mexico 
      City, Mexico.
FAU - Pineda, Carlos
AU  - Pineda C
AD  - Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de 
      Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
FAU - Martinez-Nava, Gabriela
AU  - Martinez-Nava G
AD  - Synovial Fluid Laboratory, Instituto Nacional de Rehabilitaci n LGII, Mexico 
      City, Mexico.
FAU - Gutierrez, Marwin
AU  - Gutierrez M
AD  - Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de 
      Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20220502
PL  - Mexico
TA  - Rev Invest Clin
JT  - Revista de investigacion clinica; organo del Hospital de Enfermedades de la 
      Nutricion
JID - 9421552
RN  - 0 (CARD Signaling Adaptor Proteins)
RN  - 0 (CARD8 protein, human)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (PPARGC1B protein, human)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - CARD Signaling Adaptor Proteins/genetics/metabolism
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - *Gout/genetics
MH  - Humans
MH  - *Inflammasomes/genetics/metabolism
MH  - Interleukin-1beta/genetics/metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/genetics/metabolism
MH  - Neoplasm Proteins/genetics/metabolism
MH  - Polymorphism, Single Nucleotide
MH  - RNA-Binding Proteins/genetics
OTO - NOTNLM
OT  - Gout
OT  - Inflammasome
OT  - NLRP3
OT  - SNPs
EDAT- 2022/03/22 06:00
MHDA- 2022/07/12 06:00
CRDT- 2022/03/21 22:47
PHST- 2022/03/21 22:47 [entrez]
PHST- 2022/03/22 06:00 [pubmed]
PHST- 2022/07/12 06:00 [medline]
AID - 10.24875/RIC.21000603 [doi]
PST - epublish
SO  - Rev Invest Clin. 2022 May 2;74(3):147-155. doi: 10.24875/RIC.21000603.