PMID- 35313393
OWN - NLM
STAT- MEDLINE
DCOM- 20230203
LR  - 20230227
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Print)
IS  - 2233-6079 (Linking)
VI  - 47
IP  - 1
DP  - 2023 Jan
TI  - Comparison of Insulin-Treated Patients with Ambiguous Diabetes Type with Definite 
      Type 1 and Type 2 Diabetes Mellitus Subjects: A Clinical Perspective.
PG  - 140-146
LID - 10.4093/dmj.2021.0322 [doi]
AB  - In clinical practice, the distinction between type 1 diabetes mellitus (T1DM) and 
      type 2 diabetes mellitus (T2DM) can be challenging, leaving patients with 
      "ambiguous" diabetes type. Insulin-treated patients (n=115) previously diagnosed 
      with T2DM had to be re-classified based on clinical phenotype and laboratory 
      results, and were operationally defined as having an ambiguous diabetes type. 
      They were compared against patients with definite T1DM and T2DM regarding 12 
      clinical and laboratory features typically different between diabetes types. 
      Characteristics of patients with ambiguous diabetes type, representing 
      approximately 6% of all patients with T1DM or T2DM seen at our specialized 
      clinic, fell in between those of patients with definite T1DM and T2DM, both 
      regarding individual features and with respect to a novel classification based on 
      multi-variable regression analysis (P<0.0001). In conclusion, a substantial 
      proportion of diabetes patients in a tertiary care centre presented with an 
      "ambiguous" diabetes type. Their clinical characteristics fall in between those 
      of definite T1DM or T2DM patients.
FAU - Laspe, Insa
AU  - Laspe I
AD  - Diabetes Center Bad Lauterberg, Bad Lauterberg, Germany.
FAU - Meier, Juris J
AU  - Meier JJ
AD  - Diabetes, Endocrinology and Metabolism Section, Department of Medicine I, St. 
      Josef-Hospital, Katholisches Klinikum Bochum gGmbH, Ruhr University of Bochum, 
      Bochum, Germany.
AD  - Department of Internal Medicine, Augusta-Hospital, Bochum, Germany.
FAU - Nauck, Michael A
AU  - Nauck MA
AD  - Diabetes Center Bad Lauterberg, Bad Lauterberg, Germany.
AD  - Diabetes, Endocrinology and Metabolism Section, Department of Medicine I, St. 
      Josef-Hospital, Katholisches Klinikum Bochum gGmbH, Ruhr University of Bochum, 
      Bochum, Germany.
LA  - eng
PT  - Journal Article
DEP - 20220322
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
RN  - 0 (Insulin)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy/epidemiology/diagnosis
MH  - *Diabetes Mellitus, Type 1/drug therapy/epidemiology/diagnosis
MH  - Insulin/therapeutic use
MH  - Phenotype
PMC - PMC9925152
OTO - NOTNLM
OT  - C-peptide
OT  - Diabetes mellitus, type 1
OT  - Diabetes mellitus, type 2
OT  - Diagnosis, differential
OT  - Insulin resistance
OT  - Latent autoimmune diabetes in adults
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2022/03/23 06:00
MHDA- 2023/02/04 06:00
PMCR- 2023/01/01
CRDT- 2022/03/22 00:58
PHST- 2021/11/16 00:00 [received]
PHST- 2021/12/16 00:00 [accepted]
PHST- 2022/03/23 06:00 [pubmed]
PHST- 2023/02/04 06:00 [medline]
PHST- 2022/03/22 00:58 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - dmj.2021.0322 [pii]
AID - dmj-2021-0322 [pii]
AID - 10.4093/dmj.2021.0322 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2023 Jan;47(1):140-146. doi: 10.4093/dmj.2021.0322. Epub 2022 
      Mar 22.