PMID- 35314949
OWN - NLM
STAT- MEDLINE
DCOM- 20220715
LR  - 20220715
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 16
IP  - 4
DP  - 2022 Aug
TI  - Functional connectivity modulations during offset analgesia in chronic pain 
      patients: an fMRI study.
PG  - 1794-1802
LID - 10.1007/s11682-022-00652-7 [doi]
AB  - Patients with neuropathic pain and fibromyalgia showed reduced or absent offset 
      analgesia (OA) response and attenuated cerebral activity in descending pain 
      modulatory and reward systems in patients. However, neural network modifications 
      of OA in chronic pain have not been determined. We enrolled 23 patients with 
      various chronic pain and 17 age- and gender- matched healthy controls. All 
      participants were given OA-related noxious thermal stimuli, including 3 repeats 
      of offset analgesia paradigm at 46-47-46  degrees C and constant paradigm at 46  degrees C on the 
      left volar forearm under whole-brain functional magnitude resonance imaging 
      (fMRI). We evaluated magnitude of OA, examined OA modulated functional 
      connectivity using psychophysiological interaction analysis and resting-state 
      functional connectivity analysis and explored their behavioral correlations in 
      patients compared with controls.Compared to controls, chronic pain patients 
      showed smaller magnitude of OA (P = 0.047). OA modulated connectivity decreased 
      between posterior cingulate cortex (PCC) and right medial prefrontal cortex 
      (MPFC) in proportion to current chronic pain (P = 0.018); decreased between right 
      pallidum and right thalamus, and increased between right caudate nucleus and left 
      primary somatosensory cortex (P (FDR) < 0.05).The impaired PCC-MPFC connectivity 
      might play an important role in dysfunction of OA and contribute to pain 
      chronification.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Li, Tianjiao
AU  - Li T
AD  - Department of Anesthesiology, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University, Tokyo, Japan. tianjiaoli89@yahoo.co.jp.
FAU - Zhang, Shuo
AU  - Zhang S
AD  - Department of Anesthesiology, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Ikeda, Eri
AU  - Ikeda E
AD  - Department of Anesthesiology, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Kobinata, Hiroyuki
AU  - Kobinata H
AD  - Department of Anesthesiology, Tokyo Medical and Dental University Hospital of 
      Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220322
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - *Analgesia/methods
MH  - Brain Mapping
MH  - *Chronic Pain/diagnostic imaging/drug therapy
MH  - *Fibromyalgia
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Pain Management/methods
OTO - NOTNLM
OT  - Chronic pain
OT  - Functional connectivity
OT  - Offset analgesia
OT  - Psychophysiological interaction analysis
OT  - fMRI
EDAT- 2022/03/23 06:00
MHDA- 2022/07/16 06:00
CRDT- 2022/03/22 05:38
PHST- 2022/02/11 00:00 [accepted]
PHST- 2022/03/23 06:00 [pubmed]
PHST- 2022/07/16 06:00 [medline]
PHST- 2022/03/22 05:38 [entrez]
AID - 10.1007/s11682-022-00652-7 [pii]
AID - 10.1007/s11682-022-00652-7 [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2022 Aug;16(4):1794-1802. doi: 10.1007/s11682-022-00652-7. 
      Epub 2022 Mar 22.