PMID- 35316094
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20220426
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 25
IP  - 2
DP  - 2022 Apr
TI  - Baicalein May Act as a Caloric Restriction Mimetic Candidate to Improve the 
      Antioxidant Profile in a Natural Rodent Model of Aging.
PG  - 70-78
LID - 10.1089/rej.2021.0071 [doi]
AB  - Caloric restriction (CR) is the most effective intervention for extending the 
      life span of vertebrate and invertebrate aging models. Calorie restriction 
      mimetics (CRMs), which are synthetic or natural chemicals that mimic the 
      biochemical, hormonal, and physiological consequences of calorie restriction, are 
      being researched for antiaging benefits. Baicalein is a plant-derived polyphenol 
      that has the potential of antioxidant, anti-inflammatory, and autophagy inducer. 
      The objective of this study is to evaluate the antiaging, anti-inflammatory, and 
      antioxidant role of Baicalein in erythrocyte membrane and plasma, and evaluate 
      the efficacy of Baicalein to act as a CRM candidate. This study evaluates the 
      effect of Baicalein on aging biomarkers in normal and aged rats. We study various 
      pro- and antioxidant markers, erythrocyte membrane transporters, and eryptosis. 
      Baicalein supplementation in male Wistar rats significantly alleviated 
      pro-oxidant markers and improved antioxidant profile. Improvement was also 
      observed in age-induced alterations in membrane transporters, and eryptosis. 
      Based on the aforementioned observations we conclude that Baicalein has the 
      potential to maintain extracellular reactive oxygen species levels and redox 
      homeostasis during the aging process, an effect that is similar to CR. Thus, 
      Baicalein may be a potent CRM candidate for antiaging interventions.
FAU - Tripathi, Shambhoo Sharan
AU  - Tripathi SS
AD  - Department of Biochemistry, University of Allahabad, Allahabad, India.
FAU - Kumar, Raushan
AU  - Kumar R
AD  - Department of Biochemistry, University of Allahabad, Allahabad, India.
FAU - Bissoyi, Akalabya
AU  - Bissoyi A
AD  - Department of Biochemistry, Institute of Biochemistry, Food Science and 
      Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel.
FAU - Rizvi, Syed Ibrahim
AU  - Rizvi SI
AD  - Department of Biochemistry, University of Allahabad, Allahabad, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Flavanones)
RN  - 0 (Reactive Oxygen Species)
RN  - 49QAH60606 (baicalein)
SB  - IM
MH  - Animals
MH  - *Antioxidants/pharmacology
MH  - Biomarkers
MH  - *Caloric Restriction
MH  - Flavanones
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species
MH  - Rodentia
OTO - NOTNLM
OT  - Baicalein
OT  - CRM
OT  - aging
OT  - erythrocyte
OT  - oxidative stress
EDAT- 2022/03/23 06:00
MHDA- 2022/04/27 06:00
CRDT- 2022/03/22 17:15
PHST- 2022/03/23 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2022/03/22 17:15 [entrez]
AID - 10.1089/rej.2021.0071 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2022 Apr;25(2):70-78. doi: 10.1089/rej.2021.0071.