PMID- 35316101
OWN - NLM
STAT- MEDLINE
DCOM- 20221205
LR  - 20230105
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 167
IP  - 6
DP  - 2022 Dec
TI  - Olfactory Outcomes After Middle Turbinate Resection in Endoscopic Transsphenoidal 
      Surgery: A Prospective Randomized Study.
PG  - 964-970
LID - 10.1177/01945998221086202 [doi]
AB  - OBJECTIVE: Endoscopic endonasal transsphenoidal surgery is safe and effective for 
      sellar and parasellar tumor removal. Partial middle turbinate (MT) resection is 
      sometimes performed to optimize the surgical field and facilitate postoperative 
      care. Disturbances in olfaction are concerning because of the lack of randomized 
      studies in this field. STUDY DESIGN: Prospective randomized trial. SETTING: 
      Single academic medical center. METHODS: We resected the lower halves of 
      bilateral MTs in the resected group and laterally fractured bilateral MTs in the 
      preserved group. Olfactory outcomes and sinonasal conditions were assessed by 
      using the validated Taiwan Smell Identification Test and Lund-Kennedy Endoscopy 
      Score, respectively. Forty-nine patients were enrolled in the final analysis, of 
      whom 23 underwent partial MT resection. RESULTS: The average Taiwan Smell 
      Identification Test result was 36.9 one month after surgery, with a significant 
      change of -4.4 +/- 3.1 (mean +/- SD; P < .01) from baseline. The impact was not 
      significant at 3 months (-2.1 +/- 2.6, P = .13) or 6 months (0.3 +/- 2.0, P = .79). 
      Between the MT resection and preservation groups, there were no significant 
      differences at postoperative 1 month (P = .60), 3 months (P = .86), and 6 months 
      (P > .99). Lund-Kennedy Endoscopy Score was still higher at 3 months (P = .006) 
      after surgery but returned to the preoperative level at 6 months (P = .63). 
      CONCLUSIONS: Endoscopic endonasal transsphenoidal surgery may affect olfaction at 
      1 month after surgery, and olfactory function is expected to return after 3 
      months. Partial MT resection did not result in additional olfactory loss. It is 
      safe to perform partial MT resection during surgery without compromising the 
      olfactory outcomes.
FAU - Hsu, Pei-Yuan
AU  - Hsu PY
AD  - Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, 
      Taipei.
FAU - Hsieh, Li-Chun
AU  - Hsieh LC
AD  - Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, 
      Taipei.
AD  - School of Medicine, Mackay Medical College, New Taipei City.
AD  - Department of Audiology and Speech Language Pathology, Mackay Medical College, 
      New Taipei City.
FAU - Wang, Yu-Hsuan
AU  - Wang YH
AD  - Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, 
      Taipei.
FAU - Chen, Shiu-Jau
AU  - Chen SJ
AD  - School of Medicine, Mackay Medical College, New Taipei City.
AD  - Department of Neurosurgery, Mackay Memorial Hospital, Taipei.
FAU - Chan, Yun-Kai
AU  - Chan YK
AD  - Department of Neurosurgery, Mackay Memorial Hospital, Taipei.
FAU - Shen, Kuang-Hsuan
AU  - Shen KH
AD  - Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, 
      Taipei.
FAU - Wang, Ying-Piao
AU  - Wang YP
AD  - Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, 
      Taipei.
AD  - School of Medicine, Mackay Medical College, New Taipei City.
AD  - Department of Audiology and Speech Language Pathology, Mackay Medical College, 
      New Taipei City.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220322
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Humans
MH  - *Smell
MH  - Turbinates/surgery
MH  - Prospective Studies
MH  - *Pituitary Neoplasms/surgery
MH  - Postoperative Complications/etiology
MH  - Endoscopy/adverse effects
MH  - Treatment Outcome
OTO - NOTNLM
OT  - endoscopic endonasal approach
OT  - endoscopic transsphenoidal surgery
OT  - middle turbinate resection
OT  - olfaction
OT  - skull base surgery
EDAT- 2022/03/23 06:00
MHDA- 2022/12/06 06:00
CRDT- 2022/03/22 17:15
PHST- 2022/03/23 06:00 [pubmed]
PHST- 2022/12/06 06:00 [medline]
PHST- 2022/03/22 17:15 [entrez]
AID - 10.1177/01945998221086202 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2022 Dec;167(6):964-970. doi: 
      10.1177/01945998221086202. Epub 2022 Mar 22.