PMID- 35316109
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220624
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 31
IP  - 9-10
DP  - 2022 May
TI  - Dendritic Cell Differentiation from Human Induced Pluripotent Stem Cells: 
      Challenges and Progress.
PG  - 207-220
LID - 10.1089/scd.2021.0305 [doi]
AB  - Dendritic cells (DCs) are the major antigen-presenting cells of the immune system 
      responsible for initiating and coordinating immune responses. These abilities 
      provide potential for several clinical applications, such as the development of 
      immunogenic vaccines. However, difficulty in obtaining DCs from conventional 
      sources, such as bone marrow, peripheral blood, and cord blood, significantly 
      hinders routine application. The use of human induced pluripotent stem cells 
      (hiPSCs) is a valuable alternative for generating sufficient numbers of DCs to be 
      used in basic and preclinical studies. Despite the many challenges that must be 
      overcome to achieve an efficient protocol for obtaining the major DC types from 
      hiPSCs, recent progress has been made. In this study, we review the current state 
      of developing DCs from hiPSCs, as well as the key elements required to enable the 
      routine use of hiPSC-derived DCs in preclinical and clinical assays.
FAU - Oliveira, Nelio A J
AU  - Oliveira NAJ
AUID- ORCID: 0000-0003-0253-3487
AD  - The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
FAU - Sevim, Handan
AU  - Sevim H
AD  - Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220426
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
SB  - IM
MH  - Bone Marrow
MH  - Cell Differentiation/physiology
MH  - Dendritic Cells
MH  - Humans
MH  - *Induced Pluripotent Stem Cells/metabolism
OTO - NOTNLM
OT  - dendritic cells
OT  - differentiation
OT  - iPS
EDAT- 2022/03/23 06:00
MHDA- 2022/05/18 06:00
CRDT- 2022/03/22 17:15
PHST- 2022/03/23 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/03/22 17:15 [entrez]
AID - 10.1089/scd.2021.0305 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2022 May;31(9-10):207-220. doi: 10.1089/scd.2021.0305. Epub 2022 
      Apr 26.