PMID- 35316547
OWN - NLM
STAT- MEDLINE
DCOM- 20220422
LR  - 20220612
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 100
IP  - 6
DP  - 2022 Jun
TI  - Interleukin-18 mediated inflammatory brain injury after intracerebral hemorrhage 
      in male mice.
PG  - 1359-1369
LID - 10.1002/jnr.25044 [doi]
AB  - Interleukin-18 (IL-18), a pro-inflammatory cytokine, is thought to be associated 
      with inflammation in many neurological diseases such as ischemic stroke and 
      poststroke depression, but the role of IL-18 in inflammatory injury after 
      intracerebral hemorrhage (ICH) remains unclear. In this study, we established the 
      ICH model in male mice and found that IL-18 expression including protein and mRNA 
      levels was significantly increased in brain tissues after ICH. Meanwhile, 
      exogenous IL-18 exacerbated cerebral hematoma and neurological deficits following 
      ICH. In the IL-18 knockout group, the size of hematoma and neurological functions 
      after ICH was decreased compared with the wild-type group, suggesting the 
      critical role of IL-18 on the modulation of brain injury after ICH. Importantly, 
      exogenous IL-18 increased microglial activation in brain tissues after ICH. 
      Furthermore, IL-18 knockout resulted in the reduction of activated microglia 
      after ICH. These results indicated that IL-18 may regulate the inflammatory 
      response after ICH through the activation of microglia. Thus, IL-18 is expected 
      to be a promising therapeutic target for secondary brain injury after ICH.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Li, Hao
AU  - Li H
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Tian, Jingluan
AU  - Tian J
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Yin, Yin
AU  - Yin Y
AD  - Laboratory Animal Center, Soochow University, Suzhou, China.
FAU - Diao, Shanshan
AU  - Diao S
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zhang, Ximeng
AU  - Zhang X
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zuo, Tao
AU  - Zuo T
AD  - Department of Orthopedics, Xuzhou Medical University Affiliated Hospital, Xuzhou 
      City, China.
FAU - Miao, Zhigang
AU  - Miao Z
AD  - Institute of Neuroscience, Soochow University, Suzhou City, China.
FAU - Yang, Yi
AU  - Yang Y
AUID- ORCID: 0000-0001-7896-9485
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220322
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Animals
MH  - *Brain Injuries/complications/metabolism
MH  - Cerebral Hemorrhage/drug therapy
MH  - Hematoma/complications/metabolism
MH  - *Interleukin-18
MH  - Male
MH  - Mice
MH  - Microglia/metabolism
OTO - NOTNLM
OT  - RRID:AB-2099233
OT  - RRID:AB-2715541
OT  - RRID:AB-2895063
OT  - RRID:AB-2895090
OT  - RRID:AB-330924
OT  - RRID:AB_2535792
OT  - RRID:AB_839504
OT  - RRID:IMSR-NM-KO-190469
OT  - RRID:MGI:5657312
OT  - RRID:SCR_000306
OT  - RRID:SCR_001964
OT  - RRID:SCR_003070
OT  - behavior
OT  - brain injury
OT  - interleukin-18
OT  - intracerebral hemorrhage
OT  - microglia
EDAT- 2022/03/23 06:00
MHDA- 2022/04/23 06:00
CRDT- 2022/03/22 17:19
PHST- 2022/02/28 00:00 [revised]
PHST- 2021/06/25 00:00 [received]
PHST- 2022/03/04 00:00 [accepted]
PHST- 2022/03/23 06:00 [pubmed]
PHST- 2022/04/23 06:00 [medline]
PHST- 2022/03/22 17:19 [entrez]
AID - 10.1002/jnr.25044 [doi]
PST - ppublish
SO  - J Neurosci Res. 2022 Jun;100(6):1359-1369. doi: 10.1002/jnr.25044. Epub 2022 Mar 
      22.