PMID- 35316594
OWN - NLM
STAT- MEDLINE
DCOM- 20220324
LR  - 20220324
IS  - 0894-8275 (Print)
IS  - 0894-8275 (Linking)
VI  - 35
IP  - 1
DP  - 2022 Feb
TI  - Effect of type 2 diabetes mellitus and periodontitis on the Th1/Th2 and Th17/Treg 
      paradigm.
PG  - 55-60
AB  - PURPOSE: To investigate the effect of type 2 diabetes mellitus (T2DM) and 
      periodontitis on the Th1/Th2/Th17/Treg paradigm. METHODS: A total of 107 
      volunteers (aged 18-78 years) were recruited. Peripheral blood samples from 
      patients with periodontitis and T2DM (n= 43), patients with periodontitis only 
      (n= 20), patients with T2DM only (n= 23), and healthy controls (n= 21) were 
      collected. Blood pressure, glycated hemoglobin, fasting plasma glucose, probing 
      depth, gingival index, and clinical attachment loss were measured. The 
      circulating proportions of Th1, Th2, Th17, and Treg cells were estimated by flow 
      cytometry. The data were analyzed by a 2x2 factorial ANOVA. RESULTS: We observed 
      higher ratios of Th1/Th2 and Th17/Treg cells among patients with T2DM (P< 0.05) 
      than among healthy controls. The proportion of Th17 cells in patients with 
      periodontitis and T2DM was higher than that in other groups (P< 0.05). T2DM 
      exhibited a predominant effect on the proportion of Th1 cells (F= 18.127, P= 
      0.000) and the Th17/Treg ratio (F= 45.384, P= 0.000). A significant "T2DM x 
      periodontitis" interaction effect on the proportion of Th2, Th17, Treg cells, and 
      the Th1/Th2 ratio (P< 0.05) was also noticed. The area under curve of Th17 was 
      0.711 (95% CI= 0.584 to 0.803, P< 0.01) in the receiver operating characteristic 
      curve analysis. CLINICAL SIGNIFICANCE: The results suggest that the proportion of 
      Th2, Th17, Treg cells and the Th1/Th2 ratio is indicative of immune activation 
      and inflammation, which are evident in patients with type 2 diabetes mellitus 
      (T2DM) and periodontitis. The data indicate that the high expression of Th17 
      cells may be a relevant biological factor that can be associated with an 
      increased risk of developing chronic periodontitis in patients with T2DM.
CI  - Copyright(c)American Journal of Dentistry.
FAU - Li, Jinfeng
AU  - Li J
AD  - Department of Stomatology, Shihezi University School of Medicine, Shihezi, 
      Xinjiang, China.
FAU - Wang, Jia
AU  - Wang J
AD  - Department of Stomatology, Shihezi University School of Medicine, Shihezi, 
      Xinjiang, China.
FAU - Song, Xiangxin
AU  - Song X
AD  - Department of Endocrinology, The People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang, China.
FAU - Li, Zhiwei
AU  - Li Z
AD  - Clinical Laboratory Center, The People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang, China.
FAU - Zhang, Yanjun
AU  - Zhang Y
AD  - Department of Clinical Medicine Research Center, The People's Hospital of 
      Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
FAU - Lu, Hao
AU  - Lu H
AD  - Department of Stomatology, Shihezi University School of Medicine, Shihezi, 
      Xinjiang, China.
FAU - Chen, Xiaotao
AU  - Chen X
AD  - Department of Stomatology, The People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang, China, 1440945785@qq.com.
LA  - eng
PT  - Clinical Trial
PL  - United States
TA  - Am J Dent
JT  - American journal of dentistry
JID - 8806701
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Humans
MH  - Middle Aged
MH  - *Periodontitis
MH  - T-Lymphocytes, Regulatory/metabolism
MH  - Th1 Cells/metabolism
MH  - Th17 Cells/metabolism
MH  - Young Adult
COIS- The authors declared no conflict of interest. This work was supported by the 
      National Natural Science Foundation of China (No. 81660185), and Urumqi Science 
      and Technology Plan (No. G161310006). Mr. J. Li and Mr. Wang contributed equally 
      to this work.
EDAT- 2022/03/23 06:00
MHDA- 2022/03/25 06:00
CRDT- 2022/03/22 17:19
PHST- 2022/03/22 17:19 [entrez]
PHST- 2022/03/23 06:00 [pubmed]
PHST- 2022/03/25 06:00 [medline]
PST - ppublish
SO  - Am J Dent. 2022 Feb;35(1):55-60.