PMID- 35317136
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220324
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 10
IP  - 6
DP  - 2022 Feb 26
TI  - Primary duodenal dedifferentiated liposarcoma: A case report and literature 
      review.
PG  - 2007-2014
LID - 10.12998/wjcc.v10.i6.2007 [doi]
AB  - BACKGROUND: Dedifferentiated liposarcoma (DDLPS) is an extremely rare neoplasm 
      that exhibits various morphologies. The tumor is characterized by 
      immunoreactivity to MDM2 and CDK4 and can be confirmed by detecting MDM2 
      amplification via fluorescence in situ hybridization (FISH). Herein, we report an 
      unusual case of DDLPS arising from the duodenum. CASE SUMMARY: A 64-year-old man 
      presented with repeated abdominal pain and weight loss. Radiologic studies 
      revealed a mass of the duodenum involving the pancreas. The patient was treated 
      with pylorus-preserving pancreaticoduodenectomy. Histologically, the tumor showed 
      a high-grade sarcoma. Immunohistochemistry demonstrated that the tumor cells were 
      positive for MDM2 and CDK4 expression. MDM2 amplification was detected via FISH, 
      leading to the final diagnosis of DDLPS. Following surgery, the patient was 
      treated in the intensive care unit due to peritonitis, and died 60 d after 
      surgery. CONCLUSION: To the best of the authors' knowledge, this is the first 
      case of primary duodenal DDLPS in Korea and the third case in the 
      English-language literature. Care must be taken not to misdiagnose DDLPS as 
      another high-grade tumor. Liposarcoma should be in the differential diagnosis 
      list.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Kim, Nah Ihm
AU  - Kim NI
AD  - Department of Pathology, Chonnam National University Hospital, Gwangju 61469, 
      South Korea.
FAU - Lee, Ji Shin
AU  - Lee JS
AD  - Department of Pathology, Chonnam National University Hwasun Hospital, Hwasun 
      58128, South Korea.
FAU - Choi, Chan
AU  - Choi C
AD  - Department of Pathology, Chonnam National University Hwasun Hospital, Hwasun 
      58128, South Korea.
FAU - Nam, Jong Hee
AU  - Nam JH
AD  - Department of Pathology, Chonnam National University Hospital, Gwangju 61469, 
      South Korea.
FAU - Choi, Yoo Duk
AU  - Choi YD
AD  - Department of Pathology, Chonnam National University Hospital, Gwangju 61469, 
      South Korea.
FAU - Kim, Hee Joon
AU  - Kim HJ
AD  - Department of Surgery, Chonnam National University Hospital, Gwangju 61469, South 
      Korea.
FAU - Kim, Sung Sun
AU  - Kim SS
AD  - Department of Pathology, Chonnam National University Hospital, Gwangju 61469, 
      South Korea. succeedsoon@hanmail.net.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC8891777
OTO - NOTNLM
OT  - Case report
OT  - Duodenum
OT  - Immunohistochemistry
OT  - Liposarcoma
OT  - Primary
OT  - Small bowel
COIS- Conflict-of-interest statement: The authors declare that they have no conflict of 
      interest.
EDAT- 2022/03/24 06:00
MHDA- 2022/03/24 06:01
PMCR- 2022/02/26
CRDT- 2022/03/23 05:08
PHST- 2021/09/01 00:00 [received]
PHST- 2021/10/27 00:00 [revised]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/03/23 05:08 [entrez]
PHST- 2022/03/24 06:00 [pubmed]
PHST- 2022/03/24 06:01 [medline]
PHST- 2022/02/26 00:00 [pmc-release]
AID - 10.12998/wjcc.v10.i6.2007 [doi]
PST - ppublish
SO  - World J Clin Cases. 2022 Feb 26;10(6):2007-2014. doi: 10.12998/wjcc.v10.i6.2007.