PMID- 35317325
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220324
IS  - 1948-5204 (Print)
IS  - 1948-5204 (Electronic)
VI  - 14
IP  - 2
DP  - 2022 Feb 15
TI  - Endoscopic ultrasound-guided ablation of solid pancreatic lesions: A systematic 
      review of early outcomes with pooled analysis.
PG  - 533-542
LID - 10.4251/wjgo.v14.i2.533 [doi]
AB  - BACKGROUND: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is 
      emerging as a complementary therapeutic approach for pancreatic solid masses. 
      However, results of published data are difficult to interpret because of a 
      retrospective design and small sample size. AIM: To systematically review data on 
      EUS-RFA for solid lesions and to pool the results of the different experiences in 
      order to provide more consistent evidence in terms of safety and efficacy. 
      METHODS: A comprehensive systematic literature search on the main databases was 
      performed to identify articles in which patients with pancreatic solid lesions 
      underwent EUS-RFA. The primary outcomes were procedure-related adverse events 
      (AEs) and mortality. Secondary outcomes were the technical success rate and the 
      effects on primary tumor growth. Statistical analyses were performed using Stata 
      version 14.0. RESULTS: In total, 14 studies were included, with 120 patients 
      undergoing 153 ablations of 129 solid pancreatic lesions. The STARmed technology 
      was used in seven studies, the Habib system in six studies, and the HybridTherm 
      probe in one study. The pooled technical success rate was 99.0% (I (2): 25.82%). 
      The pooled overall AE rate was 8.0% (I (2): 11.46%). Excluding mild AEs, the 
      pooled rates of serious AEs was 1.0% (I (2): 0%). No mortality related to the 
      procedure was reported. CONCLUSION: The present pooled analysis confirms the 
      safety and feasibility of EUS-RFA.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Spadaccini, Marco
AU  - Spadaccini M
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy.
FAU - Di Leo, Milena
AU  - Di Leo M
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy.
FAU - Iannone, Andrea
AU  - Iannone A
AD  - Endoscopy Unit, Azienda Ospedale Policlinico, Bari 70124, Italy.
FAU - von den Hoff, Daan
AU  - von den Hoff D
AD  - Endoscopy Unit, Radboud University Medical Center, Nijmegen 6525 GA, Netherlands.
FAU - Fugazza, Alessandro
AU  - Fugazza A
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy.
FAU - Galtieri, Piera Alessia
AU  - Galtieri PA
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy.
FAU - Pellegatta, Gaia
AU  - Pellegatta G
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy.
FAU - Maselli, Roberta
AU  - Maselli R
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy.
FAU - Anderloni, Andrea
AU  - Anderloni A
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy.
FAU - Colombo, Matteo
AU  - Colombo M
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy.
FAU - Siersema, Peter D
AU  - Siersema PD
AD  - Endoscopy Unit, Radboud University Medical Center, Nijmegen 6525 GA, Netherlands.
FAU - Carrara, Silvia
AU  - Carrara S
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy. silvia.carrara@hunimed.eu.
FAU - Repici, Alessandro
AU  - Repici A
AD  - Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research 
      Hospital, Rozzano 20089, Milan, Italy.
LA  - eng
PT  - Journal Article
PL  - China
TA  - World J Gastrointest Oncol
JT  - World journal of gastrointestinal oncology
JID - 101532470
PMC - PMC8918998
OTO - NOTNLM
OT  - Cryotechnology
OT  - Endoscopic ultrasound
OT  - Habib
OT  - Neuroendocrine tumors
OT  - Pancreas
OT  - Pancreatic cancer
COIS- Conflict-of-interest statement: All the authors declare that they have no 
      competing interests related to the topic.
EDAT- 2022/03/24 06:00
MHDA- 2022/03/24 06:01
PMCR- 2022/02/15
CRDT- 2022/03/23 05:12
PHST- 2021/02/22 00:00 [received]
PHST- 2021/04/27 00:00 [revised]
PHST- 2021/12/31 00:00 [accepted]
PHST- 2022/03/23 05:12 [entrez]
PHST- 2022/03/24 06:00 [pubmed]
PHST- 2022/03/24 06:01 [medline]
PHST- 2022/02/15 00:00 [pmc-release]
AID - 10.4251/wjgo.v14.i2.533 [doi]
PST - ppublish
SO  - World J Gastrointest Oncol. 2022 Feb 15;14(2):533-542. doi: 
      10.4251/wjgo.v14.i2.533.