PMID- 3531834
OWN - NLM
STAT- MEDLINE
DCOM- 19861030
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 172
IP  - 1
DP  - 1986 Oct
TI  - Mutagenicity of the photochemical reaction products of pyrene with nitrogen 
      dioxide.
PG  - 19-27
AB  - The mutagenicity of the photochemical reaction products of pyrene with nitrogen 
      dioxide (NO2) and the mutagens in them were investigated for the interpretation 
      of their biological significance as genetoxic hazards of polycyclic aromatic 
      hydrocarbons (PAHs) in airborne particles. Samples extracted from the 
      photochemical reaction products of pyrene with NO2 diluted with air using a 
      high-pressure mercury lamp were mutagenic for Salmonella typhimurium strains TA97 
      and TA98 in the absence of S9 mix, with a trend to detoxification in the presence 
      of the metabolic system. The mutagens in the crude samples extracted from their 
      products, which were fractionated by normal-phase high-performance liquid 
      chromatography (HPLC) on a column of Nucleosil 100-30 with n-hexane-benzene as an 
      eluting solution, were analyzed by HPLC, mass spectrometry and Fourier transform 
      infrared (FT-IR) spectrometry. Based on these results, it was recognized that 
      1-nitropyrene (1-NP), 1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP) 
      and 1,8-dinitropyrene (1,8-DNP) was formed by the photochemical reaction of 
      pyrene with NO2. The yield of DNPs peaked at 2-3 h irradiation.
FAU - Hisamatsu, Y
AU  - Hisamatsu Y
FAU - Nishimura, T
AU  - Nishimura T
FAU - Tanabe, K
AU  - Tanabe K
FAU - Matsushita, H
AU  - Matsushita H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Mutagens)
RN  - 0 (Pyrenes)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Mass Spectrometry
MH  - *Mutagens
MH  - *Nitrogen Dioxide
MH  - Photochemistry
MH  - *Pyrenes
MH  - Salmonella typhimurium/drug effects
MH  - Spectrophotometry, Infrared
EDAT- 1986/10/01 00:00
MHDA- 1986/10/01 00:01
CRDT- 1986/10/01 00:00
PHST- 1986/10/01 00:00 [pubmed]
PHST- 1986/10/01 00:01 [medline]
PHST- 1986/10/01 00:00 [entrez]
AID - 0165-1218(86)90101-1 [pii]
AID - 10.1016/0165-1218(86)90101-1 [doi]
PST - ppublish
SO  - Mutat Res. 1986 Oct;172(1):19-27. doi: 10.1016/0165-1218(86)90101-1.