PMID- 35320489
OWN - NLM
STAT- MEDLINE
DCOM- 20220509
LR  - 20220803
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Print)
IS  - 0960-8923 (Linking)
VI  - 32
IP  - 6
DP  - 2022 Jun
TI  - Metabolic and Inflammatory Profiles of Post-Bariatric Patients with Weight 
      Recidivism.
PG  - 1849-1855
LID - 10.1007/s11695-022-06025-9 [doi]
AB  - BACKGROUND: Bariatric surgery promotes expressive weight loss, improving the 
      metabolic and inflammatory profiles. The behavior of these indicators in 
      bariatric patients with weight recidivism is unknown. We aimed to investigate 
      both profiles in bariatric patients with high ratio of weight regain (RWR), 
      comparing them with nonsurgical patients with obesity. METHODS: Forty patients 
      with obesity subjected to Roux-en-Y gastric bypass (RYGB) with high RWR composed 
      the bariatric group, and 40 controls matched for BMI, age, and gender were 
      recruited as nonsurgical group. Between-group comparisons were performed for 
      clinical history, physical examination, biochemical, metabolic, and inflammatory 
      profiles. RESULTS: Bariatric group was composed of a group with an excess weight 
      loss of 85.9 +/- 16.8%, a RWR of 56.5 +/- 19.7%, and a time since surgery of 
      10.7 +/- 4.3 years. We noticed a lower proportion of patients with type 2 diabetes 
      mellitus and dyslipidemia (P </= 0.05) and lower neck and waist circumferences 
      (P </= 0.05) in this group. No differences between groups were observed concerning 
      hip circumference, blood pressure, heart rate, total cholesterol, LDL-c, acid 
      uric, creatinine, ALT, ASP, interferon-gamma (INF-gamma), interferon gamma-induced 
      protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, 
      interleukin-1beta (IL-1 beta), interleukin-17 (IL-17), and interleukin-10 (IL-10). Of 
      note, fasting glucose; HbA1c; triglycerides; and, surprisingly, IL-6 levels were 
      lower (P </= 0.05) in the bariatric group than nonsurgical one while HDL-c level 
      was higher (P < 0.001). CONCLUSION: Expressive post-bariatric weight loss, even 
      in patients with high RWR, suggests a possible metabolic benefit/protection in 
      the long term. Probably decreased circulating levels of IL-6 are involved in it. 
      TRIAL REGISTRATION: NCT04193397.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Lopes, Karynne Grutter
AU  - Lopes KG
AUID- ORCID: 0000-0002-3005-3889
AD  - Postgraduate Program in Clinical and Experimental Physiopathology (FISCLINEX), 
      Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, 
      RJ, Brazil. kjgolrj@gmail.com.
AD  - Obesity Unit (SAI-Ob), Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital 
      Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de 
      Janeiro, RJ, Brazil. kjgolrj@gmail.com.
FAU - Romagna, Eline Coan
AU  - Romagna EC
AD  - Postgraduate Program in Clinical and Experimental Physiopathology (FISCLINEX), 
      Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, 
      RJ, Brazil.
AD  - Obesity Unit (SAI-Ob), Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital 
      Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de 
      Janeiro, RJ, Brazil.
FAU - da Silva, Daniel Sant'Anna
AU  - da Silva DS
AD  - Postgraduate Program in Clinical and Experimental Physiopathology (FISCLINEX), 
      Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, 
      RJ, Brazil.
AD  - Obesity Unit (SAI-Ob), Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital 
      Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de 
      Janeiro, RJ, Brazil.
FAU - da Costa Tavares Bezerra, Michelle
AU  - da Costa Tavares Bezerra M
AD  - Postgraduate Program in Clinical and Experimental Physiopathology (FISCLINEX), 
      Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, 
      RJ, Brazil.
AD  - Obesity Unit (SAI-Ob), Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital 
      Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de 
      Janeiro, RJ, Brazil.
FAU - Leal, Paulo Roberto Falcao
AU  - Leal PRF
AD  - Obesity Unit (SAI-Ob), Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital 
      Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de 
      Janeiro, RJ, Brazil.
AD  - Department of Surgery, Faculty of Medical Sciences, State University of Rio de 
      Janeiro, Rio de Janeiro, RJ, Brazil.
FAU - da Silva Soares Pinto, Jorge Eduardo
AU  - da Silva Soares Pinto JE
AD  - Obesity Unit (SAI-Ob), Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital 
      Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de 
      Janeiro, RJ, Brazil.
AD  - Department of Clinical Medicine, Faculty of Medical Sciences, State University of 
      Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
FAU - Bouskela, Eliete
AU  - Bouskela E
AD  - Postgraduate Program in Clinical and Experimental Physiopathology (FISCLINEX), 
      Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, 
      RJ, Brazil.
AD  - Obesity Unit (SAI-Ob), Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital 
      Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de 
      Janeiro, RJ, Brazil.
FAU - das Gracas Coelho de Souza, Maria
AU  - das Gracas Coelho de Souza M
AD  - Postgraduate Program in Clinical and Experimental Physiopathology (FISCLINEX), 
      Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, 
      RJ, Brazil.
AD  - Obesity Unit (SAI-Ob), Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital 
      Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de 
      Janeiro, RJ, Brazil.
FAU - Kraemer-Aguiar, Luiz Guilherme
AU  - Kraemer-Aguiar LG
AD  - Postgraduate Program in Clinical and Experimental Physiopathology (FISCLINEX), 
      Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, 
      RJ, Brazil.
AD  - Obesity Unit (SAI-Ob), Centro de Pesquisa Clinica Multiusuario (CePeM), Hospital 
      Universitario Pedro Ernesto (HUPE), State University of Rio de Janeiro, Rio de 
      Janeiro, RJ, Brazil.
AD  - Endocrinology, Department of Internal Medicine, Faculty of Medical Sciences, 
      University of Rio de Janeiro State, Rio de Janeiro, RJ, Brazil.
LA  - eng
SI  - ClinicalTrials.gov/NCT04193397
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220323
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Interleukin-6)
SB  - IM
MH  - *Bariatric Surgery
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/surgery
MH  - *Gastric Bypass
MH  - Humans
MH  - Interleukin-6
MH  - Obesity/surgery
MH  - *Obesity, Morbid/surgery
MH  - Treatment Outcome
MH  - Weight Loss/physiology
PMC - PMC8941653
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Chronic inflammation
OT  - Obesity
OT  - Weight regain
COIS- The authors declare no competing interests.
EDAT- 2022/03/24 06:00
MHDA- 2022/05/10 06:00
PMCR- 2022/03/23
CRDT- 2022/03/23 17:17
PHST- 2022/01/24 00:00 [received]
PHST- 2022/03/16 00:00 [accepted]
PHST- 2022/03/15 00:00 [revised]
PHST- 2022/03/24 06:00 [pubmed]
PHST- 2022/05/10 06:00 [medline]
PHST- 2022/03/23 17:17 [entrez]
PHST- 2022/03/23 00:00 [pmc-release]
AID - 10.1007/s11695-022-06025-9 [pii]
AID - 6025 [pii]
AID - 10.1007/s11695-022-06025-9 [doi]
PST - ppublish
SO  - Obes Surg. 2022 Jun;32(6):1849-1855. doi: 10.1007/s11695-022-06025-9. Epub 2022 
      Mar 23.