PMID- 35320736 OWN - NLM STAT- MEDLINE DCOM- 20220503 LR - 20220503 IS - 1532-2688 (Electronic) IS - 1059-1311 (Linking) VI - 97 DP - 2022 Apr TI - Brivaracetam as add-on treatment in patients with post-stroke epilepsy: real-world data from the BRIVAracetam add-on First Italian netwoRk Study (BRIVAFIRST). PG - 37-42 LID - S1059-1311(22)00055-3 [pii] LID - 10.1016/j.seizure.2022.03.007 [doi] AB - OBJECTIVE: Post-stroke epilepsy (PSE) is one of the most common causes of acquired epilepsy and accounts for about 10-15% of all newly diagnosed epilepsy cases. However, evidence about the clinical profile of antiseizure medications in the PSE setting is currently limited. Brivaracetam (BRV) is a rationally developed compound characterized by high-affinity binding to synaptic vesicle protein 2A. The aim of this study was to assess the 12-month effectiveness and tolerability of adjunctive BRV in patients with PSE treated in a real-world setting. METHODS: This was a subgroup analysis of patients with PSE included in the BRIVAracetam add-on First Italian netwoRk Study (BRIVAFIRST). The BRIVAFIRST was a 12-month retrospective, multicentre study including adult patients prescribed adjunctive BRV. Effectiveness outcomes included the rates of seizure response (>/=50% reduction in baseline seizure frequency), seizure-freedom, and treatment discontinuation. Safety and tolerability outcomes included the rate of treatment discontinuation due to adverse events (AEs) and the incidence of AEs. RESULTS: Patients with PSE included in the BRIVAFIRST were 75 and had a median age of 57 (interquartile range, 42-66) years. The median daily doses of BRV at 3, 6, and 12 months from starting treatment were 100 (100-150) mg, 125 (100-200) mg and 100 (100-200) mg, respectively. At 12 months, 32 (42.7%) patients had a reduction in their baseline seizure frequency by at least 50%, and the seizure freedom rates was 26/75 (34.7%). During the 1-year study period, 10 (13.3%) patients discontinued BRV. The reasons of treatment withdrawal were insufficient efficacy in 6 (8.0%) patients and poor tolerability in 4 (5.3%) patients. Adverse events were reported by 13 (20.3%) patients and were rated as mild in 84.6% and moderate in 15.4% of cases. SIGNIFICANCE: Adjunctive BRV was efficacious and generally well-tolerated when used in patients with PSE in clinical practice. Adjunctive BRV can be a suitable therapeutic option for patients with PSE. CI - Copyright (c) 2022 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. FAU - Lattanzi, Simona AU - Lattanzi S AD - Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy. Electronic address: alfierelattanzisimona@gmail.com. FAU - Canafoglia, Laura AU - Canafoglia L AD - Department of Epileptology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. FAU - Canevini, Maria Paola AU - Canevini MP AD - Epilepsy Center, Child Neuropsychiatry Unit, AAST Santi Paolo Carlo, Milan, Italy; Department of Health Sciences, Universita degli Studi, Milan, Italy. FAU - Casciato, Sara AU - Casciato S AD - IRCCS Neuromed, Pozzilli, Italy. FAU - Irelli, Emanuele Cerulli AU - Irelli EC AD - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FAU - Chiesa, Valentina AU - Chiesa V AD - Epilepsy Center, Child Neuropsychiatry Unit, AAST Santi Paolo Carlo, Milan, Italy. FAU - Dainese, Filippo AU - Dainese F AD - Epilepsy Centre, Neurology Unit, Venice, Italy. FAU - De Maria, Giovanni AU - De Maria G AD - Clinical Neurophysiology Unit, Epilepsy Center, Spedali Civili, Brescia, Italy. FAU - Didato, Giuseppe AU - Didato G AD - Epilepsy Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy. FAU - Gennaro, Giancarlo Di AU - Gennaro GD AD - IRCCS Neuromed, Pozzilli, Italy. FAU - Falcicchio, Giovanni AU - Falcicchio G AD - Department of Basic Medical Sciences, Neurosciences and Sense Organs- University Hospital of Bari "A. Moro". FAU - Fanella, Martina AU - Fanella M AD - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FAU - Ferlazzo, Edoardo AU - Ferlazzo E AD - Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy. FAU - Gangitano, Massimo AU - Gangitano M AD - Department of Biomedicine, Neuroscience, and advanced Diagnostic (BIND), University of Palermo, Palermo, Italy. FAU - La Neve, Angela AU - La Neve A AD - Department of Basic Medical Sciences, Neurosciences and Sense Organs- University Hospital of Bari "A. Moro". FAU - Mecarelli, Oriano AU - Mecarelli O AD - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FAU - Montalenti, Elisa AU - Montalenti E AD - Epilepsy Center, AOU Citta della Salute e della Scienza di Torino, Turin, Italy. FAU - Morano, Alessandra AU - Morano A AD - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FAU - Piazza, Federico AU - Piazza F AD - "Rita Levi Montalcini" Department of Neurosciences, University of Turin, Turin, Italy. FAU - Pizzanelli, Chiara AU - Pizzanelli C AD - Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Neurology Unit, Pisa University Hospital, Pisa, Italy. FAU - Pulitano, Patrizia AU - Pulitano P AD - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FAU - Ranzato, Federica AU - Ranzato F AD - Epilepsy Center, UOC Neurology, AULSS 8 Vicenza, Vicenza, Italy. FAU - Rosati, Eleonora AU - Rosati E AD - Department Neurology 2, Careggi University Hospital, Florence, Italy. FAU - Tassi, Laura AU - Tassi L AD - "C. Munari" Epilepsy Surgery Centre, Niguarda Hospital, Milan, Italy. FAU - Di Bonaventura, Carlo AU - Di Bonaventura C AD - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. CN - BRIVAFIRST Group Membership LA - eng PT - Journal Article PT - Multicenter Study DEP - 20220310 PL - England TA - Seizure JT - Seizure JID - 9306979 RN - 0 (Anticonvulsants) RN - 0 (Pyrrolidinones) RN - U863JGG2IA (brivaracetam) SB - IM MH - Adult MH - Aged MH - Anticonvulsants/therapeutic use MH - Double-Blind Method MH - Drug Therapy, Combination MH - *Epilepsy/chemically induced/etiology MH - Humans MH - Italy MH - Middle Aged MH - Pyrrolidinones/therapeutic use MH - Retrospective Studies MH - Seizures/drug therapy MH - *Stroke/complications/drug therapy MH - Treatment Outcome OTO - NOTNLM OT - Antiseizure medication OT - Brivaracetam OT - Cerebrovascular diseases OT - Focal seizures OT - Stroke FIR - Alicino, Angela IR - Alicino A IRAD- Department of Basic Medical Sciences, Neurosciences and Sense Organs- University Hospital of Bari "A. Moro". FIR - Ascoli, Michele IR - Ascoli M IRAD- Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy. FIR - Assenza, Giovanni IR - Assenza G IRAD- Dipartimento di Neurologia, Neurofisiopatologia, Neurobiologia, Universita Campus Bio-Medico, Roma, Italy. FIR - Avorio, Federica IR - Avorio F IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Badioni, Valeria IR - Badioni V IRAD- Neurology Unit, Maggiore Hospital, ASST Lodi, Lodi, Italy. FIR - Banfi, Paola IR - Banfi P IRAD- Circolo Hospital, Fondazione Macchi - ASST Settelaghi, Varese, Italy. FIR - Bartolini, Emanuele IR - Bartolini E IRAD- USL Central Tuscany, Neurology Unit, Nuovo Ospedale Santo Stefano, Prato, Italy. FIR - Basili, Luca Manfredi IR - Basili LM IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Belcastro, Vincenzo IR - Belcastro V IRAD- Neurology Unit, Maggiore Hospital, ASST Lodi, Lodi, Italy. FIR - Beretta, Simone IR - Beretta S IRAD- San Gerardo Hospital, ASST Monza, Italy. FIR - Berto, Irene IR - Berto I IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Biggi, Martina IR - Biggi M IRAD- Department Neurology 2, Careggi University Hospital, Florence, Italy. FIR - Billo, Giuseppe IR - Billo G IRAD- Epilepsy Center, UOC Neurology, AULSS 8 Vicenza, Vicenza, Italy. FIR - Boero, Giovanni IR - Boero G IRAD- Complex Structure of Neurology, SS Annunziata Hospital, Taranto, Italy. FIR - Bonanni, Paolo IR - Bonanni P IRAD- IRCCS Medea Scientific Institute, Epilepsy Unit, Conegliano, Treviso, Italy. FIR - Bongorno, Jole IR - Bongorno J IRAD- Neurology Unit, Giovanni Paolo II Hospital, Ragusa, Italy. FIR - Brigo, Francesco IR - Brigo F IRAD- Department of Neurology, Hospital of Merano (SABES-ASDAA), Merano-Meran, Italy. FIR - Caggia, Emanuele IR - Caggia E IRAD- Neurology Unit, Giovanni Paolo II Hospital, Ragusa, Italy. FIR - Cagnetti, Claudia IR - Cagnetti C IRAD- Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy. FIR - Calvello, Carmen IR - Calvello C IRAD- Dipartimento di Neurologia, Ospedale Santa Maria della Misericordia, Universita di Perugia, Perugia, Italy. FIR - Cesnik, Edward IR - Cesnik E IRAD- Neurology Unit, AOU Ferrara, Ferrara, Italy. FIR - Chianale, Gigliola IR - Chianale G IRAD- Neurology Unit, San Giovanni Bosco Hospital, Turin, Italy. FIR - Ciampanelli, Domenico IR - Ciampanelli D IRAD- Institute of Clinical Neurophysiology, Department of Neuroscience, Policlinico Riuniti, Foggia, Italy. FIR - Ciuffini, Roberta IR - Ciuffini R IRAD- Department of Life, Health, and Environmental Sciences, University of L'Aquila, Epilepsy Center, Ospedale San Salvatore, L'Aquila, Italy. FIR - Cocito, Dario IR - Cocito D IRAD- Presidio Sanitario Major, Istituti Clinici Scientifici Maugeri, Turin, Italy. FIR - Colella, Donato IR - Colella D IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Contento, Margerita IR - Contento M IRAD- Department Neurology 2, Careggi University Hospital, Florence, Italy. FIR - Costa, Cinzia IR - Costa C IRAD- Dipartimento di Neurologia, Ospedale Santa Maria della Misericordia, Universita di Perugia, Perugia, Italy. FIR - Cumbo, Eduardo IR - Cumbo E IRAD- Neurodegenerative Disorders Unit, Azienda Sanitaria Provinciale di Caltanissetta, Caltanissetta, Italy. FIR - D'Aniello, Alfredo IR - D'Aniello A IRAD- IRCCS Neuromed, Pozzilli, Italy. FIR - Deleo, Francesco IR - Deleo F IRAD- Epilepsy Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy. FIR - DiFrancesco, Jacopo C IR - DiFrancesco JC IRAD- Epilepsy Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy. FIR - Di Giacomo, Roberta IR - Di Giacomo R IRAD- Epilepsy Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy. FIR - Di Liberto, Alessandra IR - Di Liberto A IRAD- Neurology Unit, San Giovanni Bosco Hospital, Turin, Italy. FIR - Domina, Elisabetta IR - Domina E IRAD- Neurology Unit, Maggiore Hospital, ASST Lodi, Lodi, Italy. FIR - Dono, Fedele IR - Dono F IRAD- Department of Neuroscience, Imaging and Clinican Science, "G. D'Annunzio" University" of Chieti-Pescara, Italy. FIR - Durante, Vania IR - Durante V IRAD- Neurology Unit, "Perrino" Hospital, Brindisi, Italy. FIR - Elia, Maurizio IR - Elia M IRAD- Oasi Research Institute- IRCCS, Troina, Italy. FIR - Estraneo, Anna IR - Estraneo A IRAD- IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy. FIR - Evangelista, Giacomo IR - Evangelista G IRAD- Department of Neuroscience, Imaging and Clinican Science, "G. D'Annunzio" University" of Chieti-Pescara, Italy. FIR - Faedda, Maria Teresa IR - Faedda MT IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Failli, Ylenia IR - Failli Y IRAD- Department Neurology 2, Careggi University Hospital, Florence, Italy. FIR - Fallica, Elisa IR - Fallica E IRAD- Neurology Unit, AOU Ferrara, Ferrara, Italy. FIR - Fattouch, Jinane IR - Fattouch J IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Ferrari, Alessandra IR - Ferrari A IRAD- Division of Clinical Neurophysiology and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genova, Italy. FIR - Ferreri, Florinda IR - Ferreri F IRAD- Department of Neurosciences, University of Padua, Padua, Italy. FIR - Fisco, Giacomo IR - Fisco G IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Fonti, Davide IR - Fonti D IRAD- University of Cagliari, Cagliari, Italy. FIR - Fortunato, Francesco IR - Fortunato F IRAD- Dipartimento di neurologia, Universita "Magna Graecia", Catanzaro, Italy. FIR - Foschi, Nicoletta IR - Foschi N IRAD- Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy. FIR - Francavilla, Teresa IR - Francavilla T IRAD- Department of Basic Medical Sciences, Neurosciences and Sense Organs- University Hospital of Bari "A. Moro". FIR - Galli, Rosita IR - Galli R IRAD- Neurology Unit, Department of Cardio-neuro-vascular Sciences, San Donato Hospital, Arezzo, Italy. FIR - Gazzina, Stefano IR - Gazzina S IRAD- Clinical Neurophysiology Unit, Epilepsy Center, Spedali Civili, Brescia, Italy. FIR - Giallonardo, Anna Teresa IR - Giallonardo AT IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Giorgi, Filippo Sean IR - Giorgi FS IRAD- Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Neurology Unit, Pisa University Hospital, Pisa, Italy. FIR - Giuliano, Loretta IR - Giuliano L IRAD- Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Section of Neurosciences, University of Catania, Catania, Italy. FIR - Habetswallner, Francesco IR - Habetswallner F IRAD- Department of Clinical Neurophysiology, Cardarelli Hospital, Naples, Italy. FIR - Izzi, Francesca IR - Izzi F IRAD- Epilepsy Centre, Neurology Unit, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy. FIR - Kassabian, Benedetta IR - Kassabian B IRAD- Department of Neurosciences, University of Padua, Padua, Italy. FIR - Labate, Angelo IR - Labate A IRAD- Dipartimento di neurologia, Universita "Magna Graecia", Catanzaro, Italy. FIR - Luisi, Concetta IR - Luisi C IRAD- Department of Neurosciences, University of Padua, Padua, Italy. FIR - Magliani, Matteo IR - Magliani M IRAD- Department Neurology 2, Careggi University Hospital, Florence, Italy. FIR - Maira, Giulia IR - Maira G IRAD- Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Section of Neurosciences, University of Catania, Catania, Italy. FIR - Mari, Luisa IR - Mari L IRAD- Epilepsy Centre, Neurology Unit, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy. FIR - Marino, Daniela IR - Marino D IRAD- Neurology Unit, Department of Cardio-neuro-vascular Sciences, San Donato Hospital, Arezzo, Italy. FIR - Mascia, Addolorata IR - Mascia A IRAD- IRCCS Neuromed, Pozzilli, Italy. FIR - Mazzeo, Alessandra IR - Mazzeo A IRAD- Institute of Clinical Neurophysiology, Department of Neuroscience, Policlinico Riuniti, Foggia, Italy. FIR - Milano, Chiara IR - Milano C IRAD- Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Neurology Unit, Pisa University Hospital, Pisa, Italy. FIR - Meletti, Stefano IR - Meletti S IRAD- Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy. FIR - Nilo, Annacarmen IR - Nilo A IRAD- Clinical Neurology Department of Neurosciences University Hospital S. Maria della Misericordia, Udine, Italy. FIR - Orlando, Biagio IR - Orlando B IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Paladin, Francesco IR - Paladin F IRAD- Epilepsy Centre, Neurology Unit, Venice, Italy. FIR - Pascarella, Maria Grazia IR - Pascarella MG IRAD- Neurology Unit, Maggiore Hospital, ASST Lodi, Lodi, Italy. FIR - Pastori, Chiara IR - Pastori C IRAD- Epilepsy Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy. FIR - Pauletto, Giada IR - Pauletto G IRAD- Neurology Unit Department of Neurosciences University Hospital S. Maria della Misericordia, Udine, Italy. FIR - Peretti, Alessia IR - Peretti A IRAD- Epilepsy Center, UOC Neurology, AULSS 8 Vicenza, Vicenza, Italy. FIR - Perri, Gabriella IR - Perri G IRAD- Neurology Unit, ASST Rhodense, Milan, Italy. FIR - Pezzella, Marianna IR - Pezzella M IRAD- Department of Clinical Neurophysiology, Cardarelli Hospital, Naples, Italy. FIR - Piccioli, Marta IR - Piccioli M IRAD- Dipartimento di neurologia, Ospedale San Filippo Neri, Roma. FIR - Pignatta, Pietro IR - Pignatta P IRAD- Neurology and epilepsy unit Humanitas Gradenigo Hospital, Turin, Italy. FIR - Pilolli, Nicola IR - Pilolli N IRAD- Complex Structure of Neurology, SS Annunziata Hospital, Taranto, Italy. FIR - Pisani, Francesco IR - Pisani F IRAD- Neurology Unit, Department of Clinical and Experimental Medicine, University of Messina, Italy. FIR - Pisani, Laura Rosa IR - Pisani LR IRAD- Neurology Unit, Cutroni-Zodda Hospital, Barcellona, Messina, Italy. FIR - Placidi, Fabio IR - Placidi F IRAD- Epilepsy Centre, Neurology Unit, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy. FIR - Pollicino, Patrizia IR - Pollicino P IRAD- IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy. FIR - Porcella, Vittoria IR - Porcella V IRAD- AOU Sassari, Sassari, Italy. FIR - Pradella, Silvia IR - Pradella S IRAD- USL Central Tuscany, Neurology Unit, Nuovo Ospedale Santo Stefano, Prato, Italy. FIR - Puligheddu, Monica IR - Puligheddu M IRAD- University of Cagliari, Cagliari, Italy. FIR - Quadri, Stefano IR - Quadri S IRAD- Neurology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy. FIR - Quarato, Pier Paolo IR - Quarato PP IRAD- IRCCS Neuromed, Pozzilli, Italy. FIR - Quintas, Rui IR - Quintas R IRAD- Epilepsy Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy. FIR - Renna, Rosaria IR - Renna R IRAD- Epilepsy Outpatient Clinic for Adults. "A. Cardarelli" Hospital, Naples, Italy. FIR - Rizzo, Giada Ricciardo IR - Rizzo GR IRAD- Epilepsy Centre, Neurology Unit, Venice, Italy. FIR - Rum, Adriana IR - Rum A IRAD- Dipartimento di neurologia e neurofisiopatologia, Aurelia Hospital, Roma. FIR - Salamone, Enrico Michele IR - Salamone EM IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Savastano, Ersilia IR - Savastano E IRAD- Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Italy. FIR - Sessa, Maria IR - Sessa M IRAD- Neurology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy. FIR - Stokelj, David IR - Stokelj D IRAD- Neurology Clinic, ASUGI, Trieste, Italy. FIR - Tartara, Elena IR - Tartara E IRAD- Epilepsy Center, IRCCS Mondino Foundation, Pavia, Italy. FIR - Tombini, Mario IR - Tombini M IRAD- Dipartimento di Neurologia, Neurofisiopatologia, Neurobiologia, Universita Campus Bio-Medico, Roma, Italy. FIR - Tumminelli, Gemma IR - Tumminelli G IRAD- Epilepsy Center, Child Neuropsychiatry Unit, AAST Santi Paolo Carlo, Milan, Italy. FIR - Vaudano, Anna Elisabetta IR - Vaudano AE IRAD- Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy. FIR - Ventura, Maria IR - Ventura M IRAD- Neurology Unit, Giovanni Paolo II Hospital, Ragusa, Italy. FIR - Vigano, Ilaria IR - Vigano I IRAD- Epilepsy Center, Child Neuropsychiatry Unit, AAST Santi Paolo Carlo, Milan, Italy. FIR - Viglietta, Emanuela IR - Viglietta E IRAD- Neurology and epilepsy unit Humanitas Gradenigo Hospital, Turin, Italy. FIR - Vignoli, Aglaia IR - Vignoli A IRAD- Department of Health Sciences, Universita degli Studi, Milan, Italy. FIR - Villani, Flavio IR - Villani F IRAD- Division of Clinical Neurophysiology and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genova, Italy. FIR - Zambrelli, Elena IR - Zambrelli E IRAD- Department of Health Sciences, Universita degli Studi, Milan, Italy. FIR - Zummo, Lelia IR - Zummo L IRAD- Neurology and Stroke Unit, P.O. ARNAS-Civico, Palermo, Italy. EDAT- 2022/03/24 06:00 MHDA- 2022/05/04 06:00 CRDT- 2022/03/23 20:05 PHST- 2022/02/13 00:00 [received] PHST- 2022/03/06 00:00 [revised] PHST- 2022/03/09 00:00 [accepted] PHST- 2022/03/24 06:00 [pubmed] PHST- 2022/05/04 06:00 [medline] PHST- 2022/03/23 20:05 [entrez] AID - S1059-1311(22)00055-3 [pii] AID - 10.1016/j.seizure.2022.03.007 [doi] PST - ppublish SO - Seizure. 2022 Apr;97:37-42. doi: 10.1016/j.seizure.2022.03.007. Epub 2022 Mar 10.