PMID- 35320864
OWN - NLM
STAT- MEDLINE
DCOM- 20221020
LR  - 20221020
IS  - 1439-3999 (Electronic)
IS  - 0023-2165 (Linking)
VI  - 239
IP  - 10
DP  - 2022 Oct
TI  - Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence 
      Tomography - A Predictor of Visual Acuity in Schizophrenia.
PG  - 1232-1238
LID - 10.1055/a-1741-7988 [doi]
AB  - BACKGROUND: The aim of this study was to evaluate the thickness of the outer 
      retinal layer (ORL) together with macular thickness and changes in the retinal 
      nerve fiber layer (RNFL) in patients with schizophrenia in comparison with 
      healthy controls. METHODS: This study included 114 eyes of 57 patients diagnosed 
      with schizophrenia and 114 eyes of 57 healthy controls. Central foveal thickness 
      (CFT), central macular thickness (CMT), and ORL thickness were measured in both 
      groups via the images obtained by spectral-domain optical coherence tomography 
      (SD-OCT). RNFL was also assessed in four quadrants (inferior, superior, temporal, 
      nasal). CMT measurements were presented as the average thickness of the macula in 
      the central 1 mm area on the Early Treatment Diabetic Retinopathy Study (ETDRS) 
      grid. The ORL thickness was defined as the distance between the external limiting 
      membrane and retinal pigment epithelium at the center of the foveal pit. RESULTS: 
      The mean age of 57 patients was 37 +/- 10 years, of whom 34 (60%) were male and 23 
      (40%) female. No statistically significant difference was found between groups in 
      terms of age and gender (p = 0.8 for age, p = 0.9 for gender). There was no 
      statistically significant difference in the mean CMT between the two groups 
      (p = 0.1). The mean ORL thickness in the two groups was 99.8 +/- 8.3 and 
      103.7 +/- 6.2, respectively, and was significantly decreased in the schizophrenia 
      group (p = 0.005). RNFL analysis demonstrated significant thinning in the 
      inferior and superior quadrants compared to healthy controls (p < 0.001 and 
      p = 0.017, respectively). CONCLUSIONS: SD-OCT findings - especially ORL and RNFL 
      thickness - may be related to the neurodegenerational changes in schizophrenia.
CI  - Thieme. All rights reserved.
FAU - Bozali, Erman
AU  - Bozali E
AD  - Sivas Cumhuriyet University Faculty of Medicine, Department of Ophthalmology, 
      Sivas, Turkey.
FAU - Yalinbas, Duygu
AU  - Yalinbas D
AUID- ORCID: 0000-0001-9001-0277
AD  - Sivas Cumhuriyet University Faculty of Medicine, Department of Ophthalmology, 
      Sivas, Turkey.
LA  - eng
PT  - Journal Article
TT  - Analyse der ausseren Netzhautschichtdicke als Pradiktor der Sehscharfe mittels 
      optischer Koharenztomografie bei Schizophrenie.
DEP - 20220323
PL  - Germany
TA  - Klin Monbl Augenheilkd
JT  - Klinische Monatsblatter fur Augenheilkunde
JID - 0014133
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Middle Aged
MH  - *Tomography, Optical Coherence/methods
MH  - Nerve Fibers
MH  - Retinal Ganglion Cells
MH  - *Schizophrenia/diagnostic imaging
MH  - Visual Acuity
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/03/24 06:00
MHDA- 2022/10/21 06:00
CRDT- 2022/03/23 20:07
PHST- 2022/03/24 06:00 [pubmed]
PHST- 2022/10/21 06:00 [medline]
PHST- 2022/03/23 20:07 [entrez]
AID - 10.1055/a-1741-7988 [doi]
PST - ppublish
SO  - Klin Monbl Augenheilkd. 2022 Oct;239(10):1232-1238. doi: 10.1055/a-1741-7988. 
      Epub 2022 Mar 23.